Human Gene CAMK2A (ENST00000671881.1) Description and Page Index
  Description: Homo sapiens calcium/calmodulin dependent protein kinase II alpha (CAMK2A), transcript variant 1, mRNA. (from RefSeq NM_015981)
RefSeq Summary (NM_015981): The product of this gene belongs to the serine/threonine protein kinases family, and to the Ca(2+)/calmodulin-dependent protein kinases subfamily. Calcium signaling is crucial for several aspects of plasticity at glutamatergic synapses. This calcium calmodulin-dependent protein kinase is composed of four different chains: alpha, beta, gamma, and delta. The alpha chain encoded by this gene is required for hippocampal long-term potentiation (LTP) and spatial learning. In addition to its calcium-calmodulin (CaM)-dependent activity, this protein can undergo autophosphorylation, resulting in CaM-independent activity. Several transcript variants encoding distinct isoforms have been identified for this gene. [provided by RefSeq, Jun 2018]. Sequence Note: The RefSeq transcript and protein were derived from transcript and genomic sequence to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on alignments. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: SRR1803613.274807.1, SRR1660807.26318.1 [ECO:0000332] ##Evidence-Data-END## ##RefSeq-Attributes-START## RefSeq Select criteria :: based on manual assertion, conservation, longest protein ##RefSeq-Attributes-END##
Gencode Transcript: ENST00000671881.1
Gencode Gene: ENSG00000070808.16
Transcript (Including UTRs)
   Position: hg38 chr5:150,219,491-150,289,773 Size: 70,283 Total Exon Count: 19 Strand: -
Coding Region
   Position: hg38 chr5:150,222,710-150,289,625 Size: 66,916 Coding Exon Count: 19 

Page IndexSequence and LinksUniProtKB CommentsMalaCardsCTDRNA-Seq Expression
Microarray ExpressionRNA StructureProtein StructureOther SpeciesGO AnnotationsmRNA Descriptions
PathwaysOther NamesMethods
Data last updated: 2019-09-04

-  Sequence and Links to Tools and Databases
Genomic Sequence (chr5:150,219,491-150,289,773)mRNA (may differ from genome)Protein (489 aa)
Gene SorterGenome BrowserOther Species FASTAGene interactionsTable SchemaBioGPS
CGAPEnsemblEntrez GeneExonPrimerGeneCardsHGNC

-  Comments and Description Text from UniProtKB
  ID: A8K161_HUMAN
DESCRIPTION: SubName: Full=Calcium/calmodulin-dependent protein kinase (CaM kinase) II alpha, isoform CRA_b; SubName: Full=cDNA FLJ75193, highly similar to Homo sapiens calcium/calmodulin-dependent protein kinase II alpha-B subunit mRNA;
SIMILARITY: Contains 1 protein kinase domain.

-  MalaCards Disease Associations
  MalaCards Gene Search: CAMK2A
Diseases sorted by gene-association score: conduct disorder (7)

-  Comparative Toxicogenomics Database (CTD)
  The following chemicals interact with this gene
  • D003024 Clozapine
  • D003042 Cocaine
  • D000431 Ethanol
  • C006253 pirinixic acid
  • C070379 1,2-bis(2-aminophenoxy)ethane N,N,N',N'-tetraacetic acid acetoxymethyl ester
  • C060229 1-(6-((3-methoxyestra-1,3,5(10)-trien-17-yl)amino)hexyl)-1H-pyrrole-2,5-dione
  • C109986 2-aminoethoxydiphenyl borate
  • C472791 3-(4'-hydroxy-3'-adamantylbiphenyl-4-yl)acrylic acid
  • C057013 7-chlorokynurenic acid
  • D000082 Acetaminophen
          more ... click here to view the complete list

-  RNA-Seq Expression Data from GTEx (53 Tissues, 570 Donors)
  Highest median expression: 128.84 RPKM in Brain - Frontal Cortex (BA9)
Total median expression: 529.03 RPKM

View in GTEx track of Genome Browser    View at GTEx portal     View GTEx Body Map

+  Microarray Expression Data
  Press "+" in the title bar above to open this section.

-  mRNA Secondary Structure of 3' and 5' UTRs
RegionFold EnergyBasesEnergy/Base
Display As
5' UTR -54.30148-0.367 Picture PostScript Text
3' UTR -1221.603219-0.379 Picture PostScript Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

-  Protein Domain and Structure Information
  InterPro Domains: Graphical view of domain structure
IPR020636 - Ca/CaM-dep_Ca-dep_prot_Kinase
IPR013543 - Ca/CaM-dep_prot_kinase-assoc
IPR011009 - Kinase-like_dom
IPR000719 - Prot_kinase_cat_dom
IPR017441 - Protein_kinase_ATP_BS
IPR002290 - Ser/Thr_dual-sp_kinase_dom
IPR008271 - Ser/Thr_kinase_AS

Pfam Domains:
PF08332 - Calcium/calmodulin dependent protein kinase II association domain
PF00069 - Protein kinase domain

ModBase Predicted Comparative 3D Structure on A8K161
The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.

-  Orthologous Genes in Other Species
  Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
MouseRatZebrafishD. melanogasterC. elegansS. cerevisiae
Genome BrowserGenome BrowserNo orthologNo orthologNo orthologNo ortholog
Gene Details     
Gene Sorter     
Protein SequenceProtein Sequence    

-  Gene Ontology (GO) Annotations with Structured Vocabulary
  Molecular Function:
GO:0000166 nucleotide binding
GO:0004672 protein kinase activity
GO:0004674 protein serine/threonine kinase activity
GO:0004683 calmodulin-dependent protein kinase activity
GO:0005516 calmodulin binding
GO:0005524 ATP binding
GO:0009931 calcium-dependent protein serine/threonine kinase activity
GO:0016301 kinase activity
GO:0035254 glutamate receptor binding

Biological Process:
GO:0000082 G1/S transition of mitotic cell cycle
GO:0002931 response to ischemia
GO:0006468 protein phosphorylation
GO:0006816 calcium ion transport
GO:0010666 positive regulation of cardiac muscle cell apoptotic process
GO:0016310 phosphorylation
GO:0018105 peptidyl-serine phosphorylation
GO:0046777 protein autophosphorylation
GO:0046928 regulation of neurotransmitter secretion
GO:0048168 regulation of neuronal synaptic plasticity
GO:0048813 dendrite morphogenesis
GO:0051928 positive regulation of calcium ion transport
GO:1902108 regulation of mitochondrial membrane permeability involved in apoptotic process

Cellular Component:
GO:0005739 mitochondrion
GO:0014069 postsynaptic density

-  Descriptions from all associated GenBank mRNAs
  AF145710 - Homo sapiens calcium/calmodulin-dependent protein kinase II alpha subunit mRNA, complete cds.
AF145711 - Homo sapiens calcium/calmodulin-dependent protein kinase II alpha-B subunit mRNA, complete cds.
BC040457 - Homo sapiens calcium/calmodulin-dependent protein kinase II alpha, mRNA (cDNA clone MGC:26106 IMAGE:4811948), complete cds.
JA482049 - Sequence 32 from Patent WO2011072091.
JA482050 - Sequence 33 from Patent WO2011072091.
JE980341 - Sequence 32 from Patent EP2862929.
JE980342 - Sequence 33 from Patent EP2862929.
AB023185 - Homo sapiens KIAA0968 mRNA for KIAA0968 protein.
JD217832 - Sequence 198856 from Patent EP1572962.
JD042058 - Sequence 23082 from Patent EP1572962.
JD264287 - Sequence 245311 from Patent EP1572962.
JD527904 - Sequence 508928 from Patent EP1572962.
JD512926 - Sequence 493950 from Patent EP1572962.
JD183117 - Sequence 164141 from Patent EP1572962.
JD251118 - Sequence 232142 from Patent EP1572962.
JD327089 - Sequence 308113 from Patent EP1572962.
JD357939 - Sequence 338963 from Patent EP1572962.
JD565771 - Sequence 546795 from Patent EP1572962.
JD496553 - Sequence 477577 from Patent EP1572962.
JD235290 - Sequence 216314 from Patent EP1572962.
JD542479 - Sequence 523503 from Patent EP1572962.
JD263016 - Sequence 244040 from Patent EP1572962.
JD348222 - Sequence 329246 from Patent EP1572962.
JD455803 - Sequence 436827 from Patent EP1572962.
JD493875 - Sequence 474899 from Patent EP1572962.
JD270486 - Sequence 251510 from Patent EP1572962.
JD524361 - Sequence 505385 from Patent EP1572962.
JD501068 - Sequence 482092 from Patent EP1572962.
JD047155 - Sequence 28179 from Patent EP1572962.
JD123125 - Sequence 104149 from Patent EP1572962.
JD290614 - Sequence 271638 from Patent EP1572962.
JD138484 - Sequence 119508 from Patent EP1572962.
JD127753 - Sequence 108777 from Patent EP1572962.
JD488767 - Sequence 469791 from Patent EP1572962.
JD478909 - Sequence 459933 from Patent EP1572962.
JD550454 - Sequence 531478 from Patent EP1572962.
JD090938 - Sequence 71962 from Patent EP1572962.
JD039757 - Sequence 20781 from Patent EP1572962.
JD166516 - Sequence 147540 from Patent EP1572962.
JD116762 - Sequence 97786 from Patent EP1572962.
JD133538 - Sequence 114562 from Patent EP1572962.
JD241066 - Sequence 222090 from Patent EP1572962.
JD298171 - Sequence 279195 from Patent EP1572962.
JD193300 - Sequence 174324 from Patent EP1572962.
JD288650 - Sequence 269674 from Patent EP1572962.
JD261506 - Sequence 242530 from Patent EP1572962.
JD343577 - Sequence 324601 from Patent EP1572962.
JD079214 - Sequence 60238 from Patent EP1572962.
JD168749 - Sequence 149773 from Patent EP1572962.
JD369502 - Sequence 350526 from Patent EP1572962.
JD433406 - Sequence 414430 from Patent EP1572962.
JD409787 - Sequence 390811 from Patent EP1572962.
JD220690 - Sequence 201714 from Patent EP1572962.
JD515601 - Sequence 496625 from Patent EP1572962.
JD191394 - Sequence 172418 from Patent EP1572962.
JD402341 - Sequence 383365 from Patent EP1572962.
JD231772 - Sequence 212796 from Patent EP1572962.
JD164003 - Sequence 145027 from Patent EP1572962.
JD130147 - Sequence 111171 from Patent EP1572962.
JD470677 - Sequence 451701 from Patent EP1572962.
JD064915 - Sequence 45939 from Patent EP1572962.
JD340611 - Sequence 321635 from Patent EP1572962.
AK289776 - Homo sapiens cDNA FLJ75193 complete cds, highly similar to Homo sapiens calcium/calmodulin-dependent protein kinase II alpha-B subunit mRNA.
JD161345 - Sequence 142369 from Patent EP1572962.
JD132661 - Sequence 113685 from Patent EP1572962.
JD067906 - Sequence 48930 from Patent EP1572962.
JD163933 - Sequence 144957 from Patent EP1572962.
JD524446 - Sequence 505470 from Patent EP1572962.
JD132550 - Sequence 113574 from Patent EP1572962.
LF383490 - JP 2014500723-A/190993: Polycomb-Associated Non-Coding RNAs.
MA619067 - JP 2018138019-A/190993: Polycomb-Associated Non-Coding RNAs.
LF211062 - JP 2014500723-A/18565: Polycomb-Associated Non-Coding RNAs.
MA446639 - JP 2018138019-A/18565: Polycomb-Associated Non-Coding RNAs.
JD350741 - Sequence 331765 from Patent EP1572962.
JD134827 - Sequence 115851 from Patent EP1572962.
JD160325 - Sequence 141349 from Patent EP1572962.
LF343661 - JP 2014500723-A/151164: Polycomb-Associated Non-Coding RNAs.
MA579238 - JP 2018138019-A/151164: Polycomb-Associated Non-Coding RNAs.
JD172297 - Sequence 153321 from Patent EP1572962.
JD427378 - Sequence 408402 from Patent EP1572962.
JD206301 - Sequence 187325 from Patent EP1572962.
JD516623 - Sequence 497647 from Patent EP1572962.
JD215046 - Sequence 196070 from Patent EP1572962.
AF091486 - Homo sapiens calmodulin-dependent protein kinase II alpha mRNA, complete cds.
AB385410 - Synthetic construct DNA, clone: pF1KA0968, Homo sapiens CAMK2A gene for calcium/calmodulin-dependent protein kinase type II alpha chain, complete cds, without stop codon, in Flexi system.
EU832105 - Synthetic construct Homo sapiens clone HAIB:100067134; DKFZo008B0725 calcium/calmodulin-dependent protein kinase (CaM kinase) II alpha protein (CAMK2A) gene, encodes complete protein.
EU832199 - Synthetic construct Homo sapiens clone HAIB:100067228; DKFZo004B0726 calcium/calmodulin-dependent protein kinase (CaM kinase) II alpha protein (CAMK2A) gene, encodes complete protein.
AK308853 - Homo sapiens cDNA, FLJ98894.
AY429524 - Homo sapiens CAMK2Av_1 mRNA sequence; alternatively spliced.

-  Biochemical and Signaling Pathways
  KEGG - Kyoto Encyclopedia of Genes and Genomes
hsa04012 - ErbB signaling pathway
hsa04020 - Calcium signaling pathway
hsa04114 - Oocyte meiosis
hsa04310 - Wnt signaling pathway
hsa04720 - Long-term potentiation
hsa04722 - Neurotrophin signaling pathway
hsa04740 - Olfactory transduction
hsa04912 - GnRH signaling pathway
hsa04916 - Melanogenesis
hsa05214 - Glioma

-  Other Names for This Gene
  Alternate Gene Symbols: A8K161, A8K161_HUMAN, hCG_38614, NM_015981, uc288let.1
UCSC ID: uc288let.1
RefSeq Accession: NM_015981
Protein: A8K161 CCDS: CCDS43386.1, CCDS43387.1

-  Methods, Credits, and Use Restrictions
  Click here for details on how this gene model was made and data restrictions if any.