Human Gene CAMK2A (ENST00000671881.1) Description and Page Index
Description: Homo sapiens calcium/calmodulin dependent protein kinase II alpha (CAMK2A), transcript variant 1, mRNA. (from RefSeq NM_015981) RefSeq Summary (NM_015981): The product of this gene belongs to the serine/threonine protein kinases family, and to the Ca(2+)/calmodulin-dependent protein kinases subfamily. Calcium signaling is crucial for several aspects of plasticity at glutamatergic synapses. This calcium calmodulin-dependent protein kinase is composed of four different chains: alpha, beta, gamma, and delta. The alpha chain encoded by this gene is required for hippocampal long-term potentiation (LTP) and spatial learning. In addition to its calcium-calmodulin (CaM)-dependent activity, this protein can undergo autophosphorylation, resulting in CaM-independent activity. Several transcript variants encoding distinct isoforms have been identified for this gene. [provided by RefSeq, Jun 2018]. Sequence Note: The RefSeq transcript and protein were derived from transcript and genomic sequence to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on alignments. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: SRR1803613.274807.1, SRR1660807.26318.1 [ECO:0000332] ##Evidence-Data-END## ##RefSeq-Attributes-START## RefSeq Select criteria :: based on manual assertion, conservation, longest protein ##RefSeq-Attributes-END## Gencode Transcript: ENST00000671881.1 Gencode Gene: ENSG00000070808.16 Transcript (Including UTRs) Position: hg38 chr5:150,219,491-150,289,773 Size: 70,283 Total Exon Count: 19 Strand: - Coding Region Position: hg38 chr5:150,222,710-150,289,625 Size: 66,916 Coding Exon Count: 19
ID:A8K161_HUMAN DESCRIPTION: SubName: Full=Calcium/calmodulin-dependent protein kinase (CaM kinase) II alpha, isoform CRA_b; SubName: Full=cDNA FLJ75193, highly similar to Homo sapiens calcium/calmodulin-dependent protein kinase II alpha-B subunit mRNA; SIMILARITY: Contains 1 protein kinase domain.
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
Pfam Domains: PF08332 - Calcium/calmodulin dependent protein kinase II association domain PF00069 - Protein kinase domain
ModBase Predicted Comparative 3D Structure on A8K161
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.