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Human Gene CCL7 (ENST00000378569.2) from GENCODE V49
  Description: C-C motif chemokine ligand 7 (from RefSeq NM_006273.4)
Gencode Transcript: ENST00000378569.2
Gencode Gene: ENSG00000108688.11
Transcript (Including UTRs)
   Position: hg38 chr17:34,270,221-34,272,242 Size: 2,022 Total Exon Count: 3 Strand: +
Coding Region
   Position: hg38 chr17:34,270,291-34,271,802 Size: 1,512 Coding Exon Count: 3 

Page IndexSequence and LinksUniProtKB CommentsPrimersMalaCardsCTD
RNA-Seq ExpressionMicroarray ExpressionRNA StructureProtein StructureOther SpeciesGO Annotations
mRNA DescriptionsPathwaysOther NamesMethods
Data last updated at UCSC: 2025-09-17 13:57:07

-  Comments and Description Text from UniProtKB
  ID: CCL7_HUMAN
DESCRIPTION: RecName: Full=C-C motif chemokine 7; AltName: Full=Monocyte chemoattractant protein 3; AltName: Full=Monocyte chemotactic protein 3; Short=MCP-3; AltName: Full=NC28; AltName: Full=Small-inducible cytokine A7; Flags: Precursor;
FUNCTION: Chemotactic factor that attracts monocytes and eosinophils, but not neutrophils. Augments monocyte anti-tumor activity. Also induces the release of gelatinase B. This protein can bind heparin. Binds to CCR1, CCR2 and CCR3.
SUBUNIT: Monomer.
SUBCELLULAR LOCATION: Secreted.
PTM: O-glycosylated.
SIMILARITY: Belongs to the intercrine beta (chemokine CC) family.
SEQUENCE CAUTION: Sequence=CAA50405.1; Type=Erroneous initiation; Sequence=CAA50406.1; Type=Erroneous initiation; Sequence=CAA51055.1; Type=Erroneous initiation;
WEB RESOURCE: Name=Wikipedia; Note=CCL7 entry; URL="http://en.wikipedia.org/wiki/CCL7";

-  Primer design for this transcript
 

Primer3Plus can design qPCR Primers that straddle exon-exon-junctions, which amplify only cDNA, not genomic DNA.
Click here to load the transcript sequence and exon structure into Primer3Plus

Exonprimer can design one pair of Sanger sequencing primers around every exon, located in non-genic sequence.
Click here to open Exonprimer with this transcript

To design primers for a non-coding sequence, zoom to a region of interest and select from the drop-down menu: View > In External Tools > Primer3


-  MalaCards Disease Associations
  MalaCards Gene Search: CCL7
Diseases sorted by gene-association score: diffuse gastric cancer (9), status asthmaticus (9), stachybotrys chartarum (8), nephrogenic systemic fibrosis (8), acute contagious conjunctivitis (8), pulmonary eosinophilia (7), onchocerciasis (6), tenosynovitis (5), demyelinating disease (2)

-  Comparative Toxicogenomics Database (CTD)
  The following chemicals interact with this gene           more ... click here to view the complete list

-  RNA-Seq Expression Data from GTEx (53 Tissues, 570 Donors)
  Highest median expression: 0.74 RPKM in Cells - Cultured fibroblasts
Total median expression: 1.43 RPKM



View in GTEx track of Genome Browser    View at GTEx portal     View GTEx Body Map

+  Microarray Expression Data
 
Expression ratio colors:

GNF Expression Atlas 2 Data from U133A and GNF1H Chips

      
      
      
     
    
     
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-  mRNA Secondary Structure of 3' and 5' UTRs
 
RegionFold EnergyBasesEnergy/Base
Display As
5' UTR -14.5070-0.207 Picture PostScript Text
3' UTR -87.70440-0.199 Picture PostScript Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

-  Protein Domain and Structure Information
  InterPro Domains: Graphical view of domain structure
IPR000827 - Chemokine_CC_CS
IPR001811 - Chemokine_IL8-like_dom

Pfam Domains:
PF00048 - Small cytokines (intecrine/chemokine), interleukin-8 like

Protein Data Bank (PDB) 3-D Structure
MuPIT help
1BO0 - NMR MuPIT 1NCV - NMR MuPIT


ModBase Predicted Comparative 3D Structure on P80098
FrontTopSide
The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.

-  Orthologous Genes in Other Species
  Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
MouseRatZebrafishD. melanogasterC. elegansS. cerevisiae
No orthologNo orthologNo orthologNo orthologNo orthologNo ortholog
      
      
      
      
      

-  Gene Ontology (GO) Annotations with Structured Vocabulary
  Molecular Function:
GO:0005125 cytokine activity
GO:0005515 protein binding
GO:0008009 chemokine activity
GO:0008201 heparin binding
GO:0031726 CCR1 chemokine receptor binding
GO:0031727 CCR2 chemokine receptor binding

Biological Process:
GO:0002548 monocyte chemotaxis
GO:0006874 cellular calcium ion homeostasis
GO:0006935 chemotaxis
GO:0006954 inflammatory response
GO:0006955 immune response
GO:0007010 cytoskeleton organization
GO:0007165 signal transduction
GO:0007186 G-protein coupled receptor signaling pathway
GO:0007267 cell-cell signaling
GO:0008360 regulation of cell shape
GO:0010332 response to gamma radiation
GO:0010469 regulation of receptor activity
GO:0030335 positive regulation of cell migration
GO:0030593 neutrophil chemotaxis
GO:0043547 positive regulation of GTPase activity
GO:0048245 eosinophil chemotaxis
GO:0070098 chemokine-mediated signaling pathway
GO:0070374 positive regulation of ERK1 and ERK2 cascade
GO:0071346 cellular response to interferon-gamma
GO:0071347 cellular response to interleukin-1
GO:0071356 cellular response to tumor necrosis factor
GO:0071361 cellular response to ethanol
GO:2000503 positive regulation of natural killer cell chemotaxis

Cellular Component:
GO:0005576 extracellular region
GO:0005615 extracellular space
GO:0005623 cell


-  Descriptions from all associated GenBank mRNAs
  X71087 - H.sapiens NC28 mRNA for monocyte chemoattractant protein (MCP-3).
LF209227 - JP 2014500723-A/16730: Polycomb-Associated Non-Coding RNAs.
MA444804 - JP 2018138019-A/16730: Polycomb-Associated Non-Coding RNAs.
BC092436 - Homo sapiens chemokine (C-C motif) ligand 7, mRNA (cDNA clone MGC:104317 IMAGE:30418073), complete cds.
BC070240 - Homo sapiens chemokine (C-C motif) ligand 7, mRNA (cDNA clone IMAGE:30418262).
BC112258 - Homo sapiens chemokine (C-C motif) ligand 7, mRNA (cDNA clone MGC:138463 IMAGE:8327726), complete cds.
BC112260 - Homo sapiens chemokine (C-C motif) ligand 7, mRNA (cDNA clone MGC:138465 IMAGE:8327728), complete cds.
JD438793 - Sequence 419817 from Patent EP1572962.
X72308 - Homo sapiens mRNA for monocyte chemotactic protein-3 (MCP-3).
JD379314 - Sequence 360338 from Patent EP1572962.
AB587424 - Synthetic construct DNA, clone: pF1KB6761, Homo sapiens CCL7 gene for chemokine (C-C motif) ligand 7, without stop codon, in Flexi system.
LF326996 - JP 2014500723-A/134499: Polycomb-Associated Non-Coding RNAs.
MA562573 - JP 2018138019-A/134499: Polycomb-Associated Non-Coding RNAs.
JD040495 - Sequence 21519 from Patent EP1572962.
HQ258695 - Synthetic construct Homo sapiens clone IMAGE:100072725 chemokine (C-C motif) ligand 7 (CCL7) (CCL7) gene, encodes complete protein.
KJ892105 - Synthetic construct Homo sapiens clone ccsbBroadEn_01499 CCL7 gene, encodes complete protein.
AF043338 - Homo sapiens monocyte chemoattractant protein 3 (MCP3) mRNA, partial cds.
LF326997 - JP 2014500723-A/134500: Polycomb-Associated Non-Coding RNAs.
MA562574 - JP 2018138019-A/134500: Polycomb-Associated Non-Coding RNAs.
LF326998 - JP 2014500723-A/134501: Polycomb-Associated Non-Coding RNAs.
MA562575 - JP 2018138019-A/134501: Polycomb-Associated Non-Coding RNAs.
JD037537 - Sequence 18561 from Patent EP1572962.
JD498374 - Sequence 479398 from Patent EP1572962.
JD482313 - Sequence 463337 from Patent EP1572962.

-  Biochemical and Signaling Pathways
  KEGG - Kyoto Encyclopedia of Genes and Genomes
hsa04060 - Cytokine-cytokine receptor interaction
hsa04062 - Chemokine signaling pathway
hsa04621 - NOD-like receptor signaling pathway

-  Other Names for This Gene
  Alternate Gene Symbols: CCL7_HUMAN, ENST00000378569.1, MCP3, NM_006273, P80098, Q569J6, SCYA6, SCYA7, uc002hhz.1, uc002hhz.2, uc002hhz.3, uc002hhz.4, uc002hhz.5
UCSC ID: ENST00000378569.2
RefSeq Accession: NM_006273.4
Protein: P80098 (aka CCL7_HUMAN)
CCDS: CCDS11278.1

-  Methods, Credits, and Use Restrictions
  Click here for details on how this gene model was made and data restrictions if any.