Human Gene CCL8 (ENST00000394620.2) Description and Page Index
Description: Homo sapiens C-C motif chemokine ligand 8 (CCL8), mRNA. (from RefSeq NM_005623) RefSeq Summary (NM_005623): This antimicrobial gene is one of several chemokine genes clustered on the q-arm of chromosome 17. Chemokines form a superfamily of secreted proteins involved in immunoregulatory and inflammatory processes. The superfamily is divided into four subfamilies based on the arrangement of N-terminal cysteine residues of the mature peptide. This chemokine is a member of the CC subfamily which is characterized by two adjacent cysteine residues. This cytokine displays chemotactic activity for monocytes, lymphocytes, basophils and eosinophils. By recruiting leukocytes to sites of inflammation this cytokine may contribute to tumor-associated leukocyte infiltration and to the antiviral state against HIV infection. [provided by RefSeq, Sep 2014]. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: Y16645.1, AV733664.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1965299, SAMEA1966682 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## CDS uses downstream in-frame AUG :: upstream AUG and CDS extension is not conserved MANE Ensembl match :: ENST00000394620.2/ ENSP00000378118.1 Protein has antimicrobial activity :: PMID: 12949249 RefSeq Select criteria :: based on single protein-coding transcript ##RefSeq-Attributes-END## Gencode Transcript: ENST00000394620.2 Gencode Gene: ENSG00000108700.5 Transcript (Including UTRs) Position: hg38 chr17:34,319,435-34,321,402 Size: 1,968 Total Exon Count: 3 Strand: + Coding Region Position: hg38 chr17:34,319,502-34,320,907 Size: 1,406 Coding Exon Count: 3
ID:CCL8_HUMAN DESCRIPTION: RecName: Full=C-C motif chemokine 8; AltName: Full=HC14; AltName: Full=Monocyte chemoattractant protein 2; AltName: Full=Monocyte chemotactic protein 2; Short=MCP-2; AltName: Full=Small-inducible cytokine A8; Contains: RecName: Full=MCP-2(6-76); Flags: Precursor; FUNCTION: Chemotactic factor that attracts monocytes, lymphocytes, basophils and eosinophils. May play a role in neoplasia and inflammatory host responses. This protein can bind heparin. The processed form MCP-2(6-76) does not show monocyte chemotactic activity, but inhibits the chemotactic effect most predominantly of CCL7, and also of CCL2 and CCL5 and CCL8. SUBUNIT: Monomer or homodimer; in equilibrium. SUBCELLULAR LOCATION: Secreted. TISSUE SPECIFICITY: Highest expression found in the small intestine and peripheral blood cells. Intermediate levels seen in the heart, placenta, lung, skeletal muscle, thymus, colon, ovary, spinal cord and pancreas. Low levels seen in the brain, liver, spleen and prostate. INDUCTION: By IFNG/IFN-gamma, mitogens and IL1/interleukin-1. PTM: N-terminal processed form MCP-2(6-76) is produced by proteolytic cleavage after secretion from peripheral blood monocytes. SIMILARITY: Belongs to the intercrine beta (chemokine CC) family. SEQUENCE CAUTION: Sequence=CAA68168.1; Type=Erroneous initiation; WEB RESOURCE: Name=Wikipedia; Note=CCL8 entry; URL="http://en.wikipedia.org/wiki/CCL8";
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
ModBase Predicted Comparative 3D Structure on P80075
The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.
Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.