ID:CCDB1_HUMAN DESCRIPTION: RecName: Full=Cyclin-D1-binding protein 1; AltName: Full=Grap2 and cyclin-D-interacting protein; AltName: Full=Human homolog of Maid; FUNCTION: May negatively regulate cell cycle progression. May act at least in part via inhibition of the cyclin-D1/CDK4 complex, thereby preventing phosphorylation of RB1 and blocking E2F- dependent transcription. SUBUNIT: Interacts with CCND1 and GRAP2. May also interact with COPS5, RPLP0, SIRT6, SYF2 and TCF3. INTERACTION: Q92905:COPS5; NbExp=5; IntAct=EBI-748961, EBI-594661; P55042:RRAD; NbExp=5; IntAct=EBI-748961, EBI-3911502; P15923-1:TCF3; NbExp=3; IntAct=EBI-748961, EBI-769645; SUBCELLULAR LOCATION: Cytoplasm. Nucleus. TISSUE SPECIFICITY: Ubiquitously expressed. Expression is down- regulated in a variety of tumor types including breast, colon, prostate and rectal tumors, and is up-regulated in certain hepatic carcinomas. DEVELOPMENTAL STAGE: Expression may increase during differentiation. INDUCTION: Expression is induced by sodium butyrate, an inhibitor of colon cancer cell proliferation. PTM: Phosphorylated. SIMILARITY: Belongs to the CCNDBP1 family. SEQUENCE CAUTION: Sequence=AAD11777.1; Type=Frameshift; Positions=8, 14, 18; Sequence=AAP97163.1; Type=Frameshift; Positions=17, 40;
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
ModBase Predicted Comparative 3D Structure on O95273
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
Sequence and Links to Tools and Databases 
Microarray Expression Data 
