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Human Gene CCNY (ENST00000374704.8) from GENCODE V50
  Description: cyclin Y, transcript variant 1 (from RefSeq NM_145012.6)
Gencode Transcript: ENST00000374704.8
Gencode Gene: ENSG00000108100.20
Transcript (Including UTRs)
   Position: hg38 chr10:35,336,509-35,572,667 Size: 236,159 Total Exon Count: 10 Strand: +
Coding Region
   Position: hg38 chr10:35,337,054-35,569,170 Size: 232,117 Coding Exon Count: 10 

Page IndexSequence and LinksUniProtKB CommentsPrimersCTDRNA-Seq Expression
Microarray ExpressionRNA StructureProtein StructureOther SpeciesGO AnnotationsmRNA Descriptions
Other NamesMethods
Data last updated at UCSC: 2026-07-12 09:30:09

-  Comments and Description Text from UniProtKB
  ID: CCNY_HUMAN
DESCRIPTION: RecName: Full=Cyclin-Y; Short=Cyc-Y; AltName: Full=Cyclin box protein 1; AltName: Full=Cyclin fold protein 1; AltName: Full=cyclin-X;
FUNCTION: Positive regulatory subunit of the cyclin-dependent kinases CDK14/PFTK1 and CDK16. Acts as a cell-cycle regulator of Wnt signaling pathway during G2/M phase by recruiting CDK14/PFTK1 to the plasma membrane and promoting phosphorylation of LRP6, leading to the activation of the Wnt signaling pathway. Recruits CDK16 to the plasma membrane. Isoform 3 might play a role in the activation of MYC-mediated transcription.
SUBUNIT: Interacts with CDK14, CDK16 and LRP6.
SUBCELLULAR LOCATION: Cell membrane; Lipid-anchor; Cytoplasmic side.
SUBCELLULAR LOCATION: Isoform 3: Nucleus.
TISSUE SPECIFICITY: Widely expressed.
DEVELOPMENTAL STAGE: Enriched at G2/M.
PTM: Ubiquitinated; leading to its degradation.
SIMILARITY: Belongs to the cyclin family. Cyclin Y subfamily.
SIMILARITY: Contains 1 cyclin N-terminal domain.
SEQUENCE CAUTION: Sequence=AAH69224.1; Type=Erroneous initiation;

-  Primer design for this transcript
 

Primer3Plus can design qPCR Primers that straddle exon-exon-junctions, which amplify only cDNA, not genomic DNA.
Click here to load the transcript sequence and exon structure into Primer3Plus

Exonprimer can design one pair of Sanger sequencing primers around every exon, located in non-genic sequence.
Click here to open Exonprimer with this transcript

To design primers for a non-coding sequence, zoom to a region of interest and select from the drop-down menu: View > In External Tools > Primer3


-  Comparative Toxicogenomics Database (CTD)
  The following chemicals interact with this gene           more ... click here to view the complete list

-  RNA-Seq Expression Data from GTEx (53 Tissues, 570 Donors)
  Highest median expression: 81.07 RPKM in Testis
Total median expression: 857.48 RPKM



View in GTEx track of Genome Browser    View at GTEx portal     View GTEx Body Map

+  Microarray Expression Data
 
Expression ratio colors:

GNF Expression Atlas 2 Data from U133A and GNF1H Chips

      
      
      
     
    
     
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-  mRNA Secondary Structure of 3' and 5' UTRs
 
RegionFold EnergyBasesEnergy/Base
Display As
5' UTR -327.60545-0.601 Picture PostScript Text
3' UTR -969.703497-0.277 Picture PostScript Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

-  Protein Domain and Structure Information
  InterPro Domains: Graphical view of domain structure
IPR013763 - Cyclin-like
IPR006671 - Cyclin_N
IPR012399 - Cyclin_Y

Pfam Domains:
PF00134 - Cyclin, N-terminal domain

ModBase Predicted Comparative 3D Structure on Q8ND76
FrontTopSide
The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.

-  Orthologous Genes in Other Species
  Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
MouseRatZebrafishD. melanogasterC. elegansS. cerevisiae
Genome BrowserGenome BrowserGenome BrowserGenome BrowserGenome BrowserNo ortholog
Gene Details     
Gene Sorter     
MGIRGDEnsemblEnsemblWormBase 
Protein SequenceProtein SequenceProtein SequenceProtein SequenceProtein Sequence 
AlignmentAlignmentAlignmentAlignmentAlignment 

-  Gene Ontology (GO) Annotations with Structured Vocabulary
  Molecular Function:
GO:0005515 protein binding
GO:0016538 cyclin-dependent protein serine/threonine kinase regulator activity
GO:0019901 protein kinase binding

Biological Process:
GO:0000079 regulation of cyclin-dependent protein serine/threonine kinase activity
GO:0000086 G2/M transition of mitotic cell cycle
GO:0007049 cell cycle
GO:0016055 Wnt signaling pathway
GO:0045737 positive regulation of cyclin-dependent protein serine/threonine kinase activity
GO:0051301 cell division
GO:0060828 regulation of canonical Wnt signaling pathway

Cellular Component:
GO:0000308 cytoplasmic cyclin-dependent protein kinase holoenzyme complex
GO:0005634 nucleus
GO:0005886 plasma membrane
GO:0016020 membrane


-  Descriptions from all associated GenBank mRNAs
  AK057280 - Homo sapiens cDNA FLJ32718 fis, clone TESTI2000830.
AF429969 - Homo sapiens cyclin-box carrying protein isoform mRNA, complete cds.
BC104801 - Homo sapiens cyclin Y, mRNA (cDNA clone MGC:132461 IMAGE:8143804), complete cds.
BC104773 - Homo sapiens cyclin Y, mRNA (cDNA clone MGC:132433 IMAGE:8143776), complete cds.
BC143450 - Homo sapiens cyclin Y, mRNA (cDNA clone MGC:176975 IMAGE:9051958), complete cds.
BC143455 - Homo sapiens cyclin Y, mRNA (cDNA clone MGC:176980 IMAGE:9051963), complete cds.
AK314666 - Homo sapiens cDNA, FLJ95513, highly similar to Homo sapiens cyclin fold protein 1 (CFP1), mRNA.
AF413522 - Homo sapiens cyclin-box carrying protein (CBCP1) mRNA, complete cds.
AY504868 - Homo sapiens cyclin Y mRNA, complete cds.
LF385229 - JP 2014500723-A/192732: Polycomb-Associated Non-Coding RNAs.
MA620806 - JP 2018138019-A/192732: Polycomb-Associated Non-Coding RNAs.
AK303283 - Homo sapiens cDNA FLJ54216 complete cds, highly similar to Cyclin fold protein 1.
AL834355 - Homo sapiens mRNA; cDNA DKFZp547F237 (from clone DKFZp547F237).
BC094815 - Homo sapiens cyclin Y, mRNA (cDNA clone MGC:104797 IMAGE:6340750), complete cds.
BC069224 - Homo sapiens cyclin Y, mRNA (cDNA clone IMAGE:30389701), partial cds.
BC050310 - Homo sapiens cDNA clone IMAGE:5264499, containing frame-shift errors.
AF465728 - Homo sapiens cyclin fold protein 1 variant a (CFP1) mRNA, complete cds; alternatively spliced.
AF465729 - Homo sapiens cyclin fold protein 1 variant b (CFP1) mRNA, complete cds; alternatively spliced.
AB462996 - Synthetic construct DNA, clone: pF1KB8634, Homo sapiens CCNY gene for cyclin Y, without stop codon, in Flexi system.
AM392857 - Synthetic construct Homo sapiens clone IMAGE:100003078 for hypothetical protein (C10orf9 gene).
AM392659 - Synthetic construct Homo sapiens clone IMAGE:100003082 for hypothetical protein (C10orf9 gene).
KJ895834 - Synthetic construct Homo sapiens clone ccsbBroadEn_05228 CCNY gene, encodes complete protein.
JD406059 - Sequence 387083 from Patent EP1572962.
LF342612 - JP 2014500723-A/150115: Polycomb-Associated Non-Coding RNAs.
MA578189 - JP 2018138019-A/150115: Polycomb-Associated Non-Coding RNAs.
LF342611 - JP 2014500723-A/150114: Polycomb-Associated Non-Coding RNAs.
MA578188 - JP 2018138019-A/150114: Polycomb-Associated Non-Coding RNAs.
LF342606 - JP 2014500723-A/150109: Polycomb-Associated Non-Coding RNAs.
MA578183 - JP 2018138019-A/150109: Polycomb-Associated Non-Coding RNAs.
LF342601 - JP 2014500723-A/150104: Polycomb-Associated Non-Coding RNAs.
MA578178 - JP 2018138019-A/150104: Polycomb-Associated Non-Coding RNAs.
LF342593 - JP 2014500723-A/150096: Polycomb-Associated Non-Coding RNAs.
MA578170 - JP 2018138019-A/150096: Polycomb-Associated Non-Coding RNAs.
JD019397 - Sequence 421 from Patent EP1572962.
LF342589 - JP 2014500723-A/150092: Polycomb-Associated Non-Coding RNAs.
MA578166 - JP 2018138019-A/150092: Polycomb-Associated Non-Coding RNAs.
LF342588 - JP 2014500723-A/150091: Polycomb-Associated Non-Coding RNAs.
MA578165 - JP 2018138019-A/150091: Polycomb-Associated Non-Coding RNAs.
JD253038 - Sequence 234062 from Patent EP1572962.
BC015778 - Homo sapiens cyclin Y, mRNA (cDNA clone IMAGE:4856292), with apparent retained intron.
JD030943 - Sequence 11967 from Patent EP1572962.
LF342587 - JP 2014500723-A/150090: Polycomb-Associated Non-Coding RNAs.
MA578164 - JP 2018138019-A/150090: Polycomb-Associated Non-Coding RNAs.
JD207079 - Sequence 188103 from Patent EP1572962.
JD443911 - Sequence 424935 from Patent EP1572962.
JD471178 - Sequence 452202 from Patent EP1572962.
JD387797 - Sequence 368821 from Patent EP1572962.
JD464935 - Sequence 445959 from Patent EP1572962.
AK024813 - Homo sapiens cDNA: FLJ21160 fis, clone CAS09985.
JD368530 - Sequence 349554 from Patent EP1572962.
JD326627 - Sequence 307651 from Patent EP1572962.
LF342586 - JP 2014500723-A/150089: Polycomb-Associated Non-Coding RNAs.
MA578163 - JP 2018138019-A/150089: Polycomb-Associated Non-Coding RNAs.
JD346856 - Sequence 327880 from Patent EP1572962.
JD522143 - Sequence 503167 from Patent EP1572962.
JD171625 - Sequence 152649 from Patent EP1572962.
JD540780 - Sequence 521804 from Patent EP1572962.
JD313025 - Sequence 294049 from Patent EP1572962.
JD502818 - Sequence 483842 from Patent EP1572962.
LF342585 - JP 2014500723-A/150088: Polycomb-Associated Non-Coding RNAs.
MA578162 - JP 2018138019-A/150088: Polycomb-Associated Non-Coding RNAs.
JD019341 - Sequence 365 from Patent EP1572962.
LF342584 - JP 2014500723-A/150087: Polycomb-Associated Non-Coding RNAs.
MA578161 - JP 2018138019-A/150087: Polycomb-Associated Non-Coding RNAs.
JD034948 - Sequence 15972 from Patent EP1572962.
LF213671 - JP 2014500723-A/21174: Polycomb-Associated Non-Coding RNAs.
MA449248 - JP 2018138019-A/21174: Polycomb-Associated Non-Coding RNAs.

-  Other Names for This Gene
  Alternate Gene Symbols: B7ZKX9, C10orf9, CBCP1, CCNY_HUMAN, CFP1, D3DRY9, ENST00000374704.1, ENST00000374704.2, ENST00000374704.3, ENST00000374704.4, ENST00000374704.5, ENST00000374704.6, ENST00000374704.7, NM_145012, Q2M3V4, Q2TU96, Q6NT86, Q7Z4U7, Q8ND76, Q8TEX2, Q8TEX3, Q96M99, Q96P45, uc001iyw.1, uc001iyw.2, uc001iyw.3, uc001iyw.4, uc001iyw.5, uc001iyw.6, uc001iyw.7
UCSC ID: ENST00000374704.8
RefSeq Accession: NM_145012.6
Protein: Q8ND76 (aka CCNY_HUMAN)
CCDS: CCDS7189.1

-  Methods, Credits, and Use Restrictions
  Click here for details on how this gene model was made and data restrictions if any.