Human Gene CD24 (ENST00000619133.4)
  Description: Homo sapiens CD24 molecule (CD24), transcript variant 1, mRNA. (from RefSeq NM_013230)
RefSeq Summary (NM_013230): This gene encodes a sialoglycoprotein that is expressed on mature granulocytes and B cells and modulates growth and differentiation signals to these cells. The precursor protein is cleaved to a short 32 amino acid mature peptide which is anchored via a glycosyl phosphatidylinositol (GPI) link to the cell surface. This gene was missing from previous genome assemblies, but is properly located on chromosome 6. Non-transcribed pseudogenes have been designated on chromosomes 1, 15, 20, and Y. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Apr 2014].
Gencode Transcript: ENST00000619133.4
Gencode Gene: ENSG00000272398.6
Transcript (Including UTRs)
   Position: hg38 chr6:106,969,831-106,975,465 Size: 5,635 Total Exon Count: 3 Strand: -
Coding Region
   Position: hg38 chr6:106,971,661-106,974,646 Size: 2,986 Coding Exon Count: 2 

Page IndexSequence and LinksUniProtKB CommentsCTDMicroarray ExpressionRNA Structure
Protein StructureOther SpeciesGO AnnotationsmRNA DescriptionsPathwaysOther Names
Data last updated at UCSC: 2021-01-14 15:32:12

-  Sequence and Links to Tools and Databases
Genomic Sequence (chr6:106,969,831-106,975,465)mRNA (may differ from genome)Protein (80 aa)
Gene SorterGenome BrowserOther Species FASTAGene interactionsTable SchemaBioGPS
CGAPEnsemblEntrez GeneExonPrimerGeneCardsHGNC

-  Comments and Description Text from UniProtKB
DESCRIPTION: RecName: Full=Signal transducer CD24; AltName: Full=Small cell lung carcinoma cluster 4 antigen; AltName: CD_antigen=CD24; Flags: Precursor;
FUNCTION: Modulates B-cell activation responses. Signaling could be triggered by the binding of a lectin-like ligand to the CD24 carbohydrates, and transduced by the release of second messengers derived from the GPI-anchor. Promotes AG-dependent proliferation of B-cells, and prevents their terminal differentiation into antibody-forming cells.
SUBUNIT: Interacts with LYN and FGR in a cell-type specific manner. Binds FRG in a small cell cancer line, LYN in the erythroleukemia cell line K562 and in Burkitt's lymphoma.
INTERACTION: P07948:LYN; NbExp=6; IntAct=EBI-6267018, EBI-79452;
SUBCELLULAR LOCATION: Cell membrane; Lipid-anchor, GPI-anchor.
TISSUE SPECIFICITY: B-cells. Expressed in a number of B-cell lines including P32/SH and Namalwa. Expressed in erythroleukemia cell and small cell lung carcinoma cell lines. Also expressed on the surface of T-cells.
INDUCTION: Expression is lost when primary B-cells are induced to differentiate in antibody-forming cells.
PTM: Extensively O-glycosylated.
DISEASE: Genetic variations in CD24 are associated with susceptibility to multiple sclerosis (MS) [MIM:126200]. A multifactorial, inflammatory, demyelinating disease of the central nervous system. Sclerotic lesions are characterized by perivascular infiltration of monocytes and lymphocytes and appear as indurated areas in pathologic specimens (sclerosis in plaques). The pathological mechanism is regarded as an autoimmune attack of the myelin sheat, mediated by both cellular and humoral immunity. Clinical manifestations include visual loss, extra-ocular movement disorders, paresthesias, loss of sensation, weakness, dysarthria, spasticity, ataxia and bladder dysfunction. Genetic and environmental factors influence susceptibility to the disease. Note=Polymorphisms in CD24 may act as a genetic modifier for susceptibility and progression of MS in some populations, perhaps by affecting the efficiency of CD24 expression on the cell surface.
SIMILARITY: Belongs to the CD24 family.
SEQUENCE CAUTION: Sequence=AAD14170.1; Type=Erroneous initiation;

-  Comparative Toxicogenomics Database (CTD)
  The following chemicals interact with this gene           more ... click here to view the complete list

+  Microarray Expression Data
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-  mRNA Secondary Structure of 3' and 5' UTRs
RegionFold EnergyBasesEnergy/Base
Display As
5' UTR -209.50440-0.476 Picture PostScript Text
3' UTR -434.301830-0.237 Picture PostScript Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

-  Protein Domain and Structure Information
  ModBase Predicted Comparative 3D Structure on P25063
The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.

-  Orthologous Genes in Other Species
  Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
MouseRatZebrafishD. melanogasterC. elegansS. cerevisiae
No orthologNo orthologNo orthologNo orthologNo orthologNo ortholog

-  Gene Ontology (GO) Annotations with Structured Vocabulary
  Molecular Function:
GO:0004871 signal transducer activity
GO:0005515 protein binding
GO:0019901 protein kinase binding
GO:0030296 protein tyrosine kinase activator activity

Biological Process:
GO:0001666 response to hypoxia
GO:0001775 cell activation
GO:0001959 regulation of cytokine-mediated signaling pathway
GO:0002237 response to molecule of bacterial origin
GO:0002768 immune response-regulating cell surface receptor signaling pathway
GO:0007155 cell adhesion
GO:0007204 positive regulation of cytosolic calcium ion concentration
GO:0016055 Wnt signaling pathway
GO:0016477 cell migration
GO:0030856 regulation of epithelial cell differentiation
GO:0031295 T cell costimulation
GO:0032597 B cell receptor transport into membrane raft
GO:0032600 chemokine receptor transport out of membrane raft
GO:0032913 negative regulation of transforming growth factor beta3 production
GO:0042104 positive regulation of activated T cell proliferation
GO:0042325 regulation of phosphorylation
GO:0042632 cholesterol homeostasis
GO:0043406 positive regulation of MAP kinase activity
GO:0043408 regulation of MAPK cascade
GO:0043627 response to estrogen
GO:0045730 respiratory burst
GO:0061098 positive regulation of protein tyrosine kinase activity
GO:0072112 glomerular visceral epithelial cell differentiation
GO:0072139 glomerular parietal epithelial cell differentiation
GO:0097193 intrinsic apoptotic signaling pathway
GO:0098609 cell-cell adhesion
GO:2000768 positive regulation of nephron tubule epithelial cell differentiation

Cellular Component:
GO:0005622 intracellular
GO:0005886 plasma membrane
GO:0009986 cell surface
GO:0016020 membrane
GO:0031225 anchored component of membrane
GO:0031362 anchored component of external side of plasma membrane
GO:0045121 membrane raft

-  Descriptions from all associated GenBank mRNAs
  BC064619 - Homo sapiens CD24 molecule, mRNA (cDNA clone MGC:75043 IMAGE:5591617), complete cds.
AK026603 - Homo sapiens cDNA: FLJ22950 fis, clone KAT09618, highly similar to HUMCDA24A Homo sapiens CD24 signal transducer mRNA.
AK125531 - Homo sapiens cDNA FLJ43543 fis, clone PROST2006536.
D87667 - Homo sapiens brain mRNA homologous to 3'UTR of Homo sapiens CD24 gene, partial sequence.
L33930 - Homo sapiens CD24 signal transducer mRNA, complete cds and 3' region.
JD345072 - Sequence 326096 from Patent EP1572962.
JD202209 - Sequence 183233 from Patent EP1572962.
JD263138 - Sequence 244162 from Patent EP1572962.
JD326134 - Sequence 307158 from Patent EP1572962.
DQ530230 - Homo sapiens clone CS0DF007YJ17 CD24 mRNA, 3' UTR.
DQ530233 - Homo sapiens clone CS0DF027YP12 CD24 mRNA, 3' UTR.
DQ530234 - Homo sapiens clone CS0DI064YI12 CD24 mRNA, 3' UTR.
DQ530231 - Homo sapiens clone CS0DF014YG04 CD24 mRNA, 3' UTR.
DQ530232 - Homo sapiens clone CS0DF027YF12 CD24 mRNA, 3' UTR.
JD467794 - Sequence 448818 from Patent EP1572962.
M58664 - Homo sapiens CD24 signal transducer mRNA, complete cds.
JD360300 - Sequence 341324 from Patent EP1572962.
JD360301 - Sequence 341325 from Patent EP1572962.
JD389324 - Sequence 370348 from Patent EP1572962.
JD506103 - Sequence 487127 from Patent EP1572962.
JD026717 - Sequence 7741 from Patent EP1572962.
JD331965 - Sequence 312989 from Patent EP1572962.
JD369370 - Sequence 350394 from Patent EP1572962.
JD522974 - Sequence 503998 from Patent EP1572962.
JD296019 - Sequence 277043 from Patent EP1572962.
JD432813 - Sequence 413837 from Patent EP1572962.
JD327764 - Sequence 308788 from Patent EP1572962.
JD102155 - Sequence 83179 from Patent EP1572962.
JD188310 - Sequence 169334 from Patent EP1572962.
JD113224 - Sequence 94248 from Patent EP1572962.
JD225569 - Sequence 206593 from Patent EP1572962.
JD332073 - Sequence 313097 from Patent EP1572962.
JD258683 - Sequence 239707 from Patent EP1572962.
JD265763 - Sequence 246787 from Patent EP1572962.
JD377464 - Sequence 358488 from Patent EP1572962.
JD109856 - Sequence 90880 from Patent EP1572962.
JD498910 - Sequence 479934 from Patent EP1572962.
X69397 - H.sapiens CD24 gene, complete CDS.
JD305485 - Sequence 286509 from Patent EP1572962.
JD036800 - Sequence 17824 from Patent EP1572962.
JD454775 - Sequence 435799 from Patent EP1572962.
BT007404 - Homo sapiens CD24 antigen (small cell lung carcinoma cluster 4 antigen) mRNA, complete cds.
DQ890636 - Synthetic construct clone IMAGE:100003266; FLH164654.01X; RZPDo839A04158D CD24 molecule (CD24) gene, encodes complete protein.
DQ893812 - Synthetic construct Homo sapiens clone IMAGE:100008272; FLH164650.01L; RZPDo839A04157D CD24 molecule (CD24) gene, encodes complete protein.
JD464322 - Sequence 445346 from Patent EP1572962.

-  Biochemical and Signaling Pathways
  Reactome (by CSHL, EBI, and GO)

Protein P25063 (Reactome details) participates in the following event(s):

R-HSA-437234 Heat-Stable Antigen binds L1
R-HSA-373760 L1CAM interactions
R-HSA-422475 Axon guidance
R-HSA-1266738 Developmental Biology

-  Other Names for This Gene
  Alternate Gene Symbols: CD24A, CD24_HUMAN, ENST00000619133.1, ENST00000619133.2, ENST00000619133.3, NM_013230, P25063, Q16257, Q53XS0, uc032xhc.1, uc032xhc.2
UCSC ID: ENST00000619133.4
RefSeq Accession: NM_013230
Protein: P25063 (aka CD24_HUMAN)
CCDS: CCDS75499.1

-  Methods, Credits, and Use Restrictions
  Click here for details on how this gene model was made and data restrictions if any.