ID:CD244_HUMAN DESCRIPTION: RecName: Full=Natural killer cell receptor 2B4; AltName: Full=NK cell activation-inducing ligand; Short=NAIL; AltName: Full=NK cell type I receptor protein 2B4; Short=NKR2B4; Short=h2B4; AltName: CD_antigen=CD244; Flags: Precursor; FUNCTION: Modulate other receptor-ligand interactions to enhance leukocyte activation. SUBUNIT: Interacts with CD48. Following phosphorylation, it is able to recruit PTPN11/SHP-2 and SH2D1A/SAP. Binding of SH2D1A/SAP to CD244 prevents its association with PTPN11/SHP-2. INTERACTION: P09326:CD48; NbExp=2; IntAct=EBI-1580565, EBI-714770; SUBCELLULAR LOCATION: Membrane; Single-pass type I membrane protein (Potential). TISSUE SPECIFICITY: Expressed in spleen, PBL, followed by lung, liver, testis and small intestine. Expressed not only in NK cells, but also on monocytes and basophils. SIMILARITY: Contains 2 Ig-like (immunoglobulin-like) domains.
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
ModBase Predicted Comparative 3D Structure on Q9BZW8
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
Sequence and Links to Tools and Databases 
Microarray Expression Data 
