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Human Gene CD300C (ENST00000330793.2) from GENCODE V50
  Description: CD300c molecule (from RefSeq NM_006678.5)
Gencode Transcript: ENST00000330793.2
Gencode Gene: ENSG00000167850.6
Transcript (Including UTRs)
   Position: hg38 chr17:74,541,073-74,546,115 Size: 5,043 Total Exon Count: 4 Strand: -
Coding Region
   Position: hg38 chr17:74,541,589-74,545,782 Size: 4,194 Coding Exon Count: 4 

Page IndexSequence and LinksUniProtKB CommentsPrimersCTDRNA-Seq Expression
Microarray ExpressionRNA StructureProtein StructureOther SpeciesGO AnnotationsmRNA Descriptions
PathwaysOther NamesMethods
Data last updated at UCSC: 2026-07-12 09:30:09

-  Comments and Description Text from UniProtKB
  ID: CLM6_HUMAN
DESCRIPTION: RecName: Full=CMRF35-like molecule 6; Short=CLM-6; AltName: Full=CD300 antigen-like family member C; AltName: Full=CMRF35-A1; Short=CMRF-35; AltName: Full=Immunoglobulin superfamily member 16; Short=IgSF16; AltName: CD_antigen=CD300c; Flags: Precursor;
SUBCELLULAR LOCATION: Cell membrane; Single-pass type I membrane protein (Potential).
TISSUE SPECIFICITY: Present on the surface of monocytes, neutrophils, a proportion of peripheral blood T- and B-lymphocytes and lymphocytic cell lines.
SIMILARITY: Belongs to the CD300 family.
SIMILARITY: Contains 1 Ig-like V-type (immunoglobulin-like) domain.

-  Primer design for this transcript
 

Primer3Plus can design qPCR Primers that straddle exon-exon-junctions, which amplify only cDNA, not genomic DNA.
Click here to load the transcript sequence and exon structure into Primer3Plus

Exonprimer can design one pair of Sanger sequencing primers around every exon, located in non-genic sequence.
Click here to open Exonprimer with this transcript

To design primers for a non-coding sequence, zoom to a region of interest and select from the drop-down menu: View > In External Tools > Primer3


-  Comparative Toxicogenomics Database (CTD)
  The following chemicals interact with this gene

-  RNA-Seq Expression Data from GTEx (53 Tissues, 570 Donors)
  Highest median expression: 10.67 RPKM in Whole Blood
Total median expression: 41.37 RPKM



View in GTEx track of Genome Browser    View at GTEx portal     View GTEx Body Map

+  Microarray Expression Data
 
Expression ratio colors:

GTEx Gene Expression

       
      
       
       
      
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GNF Expression Atlas 2 Data from U133A and GNF1H Chips

      
      
      
     
    
     
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-  mRNA Secondary Structure of 3' and 5' UTRs
 
RegionFold EnergyBasesEnergy/Base
Display As
5' UTR -133.00333-0.399 Picture PostScript Text
3' UTR -170.00516-0.329 Picture PostScript Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

-  Protein Domain and Structure Information
  InterPro Domains: Graphical view of domain structure
IPR007110 - Ig-like
IPR013783 - Ig-like_fold
IPR003599 - Ig_sub
IPR013106 - Ig_V-set

Pfam Domains:
PF07686 - Immunoglobulin V-set domain

ModBase Predicted Comparative 3D Structure on Q08708
FrontTopSide
The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.

-  Orthologous Genes in Other Species
  Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
MouseRatZebrafishD. melanogasterC. elegansS. cerevisiae
Genome BrowserNo orthologNo orthologNo orthologNo orthologNo ortholog
Gene Details     
Gene Sorter     
MGI     
Protein Sequence     
Alignment     

-  Gene Ontology (GO) Annotations with Structured Vocabulary
  Molecular Function:
GO:0004888 transmembrane signaling receptor activity

Biological Process:
GO:0002376 immune system process
GO:0006968 cellular defense response
GO:0007165 signal transduction
GO:0050776 regulation of immune response

Cellular Component:
GO:0005886 plasma membrane
GO:0005887 integral component of plasma membrane
GO:0016020 membrane
GO:0016021 integral component of membrane


-  Descriptions from all associated GenBank mRNAs
  BC022279 - Homo sapiens CD300c molecule, mRNA (cDNA clone MGC:22395 IMAGE:4692025), complete cds.
JD163454 - Sequence 144478 from Patent EP1572962.
JD280524 - Sequence 261548 from Patent EP1572962.
JD097837 - Sequence 78861 from Patent EP1572962.
JD209826 - Sequence 190850 from Patent EP1572962.
JD309754 - Sequence 290778 from Patent EP1572962.
JD163951 - Sequence 144975 from Patent EP1572962.
JD158548 - Sequence 139572 from Patent EP1572962.
JD400801 - Sequence 381825 from Patent EP1572962.
JD194189 - Sequence 175213 from Patent EP1572962.
JD392608 - Sequence 373632 from Patent EP1572962.
JD216942 - Sequence 197966 from Patent EP1572962.
JD090278 - Sequence 71302 from Patent EP1572962.
JD132061 - Sequence 113085 from Patent EP1572962.
X66171 - H.sapiens CMRF35 mRNA, complete CDS.
JD151345 - Sequence 132369 from Patent EP1572962.
JD416592 - Sequence 397616 from Patent EP1572962.
JD060342 - Sequence 41366 from Patent EP1572962.
JD483894 - Sequence 464918 from Patent EP1572962.
JD424275 - Sequence 405299 from Patent EP1572962.
JD077967 - Sequence 58991 from Patent EP1572962.
DQ892000 - Synthetic construct clone IMAGE:100004630; FLH182199.01X; RZPDo839D08138D CD300c molecule (CD300C) gene, encodes complete protein.
CU692530 - Synthetic construct Homo sapiens gateway clone IMAGE:100022164 5' read CD300C mRNA.
KJ893148 - Synthetic construct Homo sapiens clone ccsbBroadEn_02542 CD300C gene, encodes complete protein.
DQ895190 - Synthetic construct Homo sapiens clone IMAGE:100009650; FLH182195.01L; RZPDo839D08137D CD300c molecule (CD300C) gene, encodes complete protein.
JD204806 - Sequence 185830 from Patent EP1572962.
JD103719 - Sequence 84743 from Patent EP1572962.
JD049679 - Sequence 30703 from Patent EP1572962.
JD218368 - Sequence 199392 from Patent EP1572962.
JD055623 - Sequence 36647 from Patent EP1572962.
JD055677 - Sequence 36701 from Patent EP1572962.
JD532770 - Sequence 513794 from Patent EP1572962.
JD416706 - Sequence 397730 from Patent EP1572962.
JD107443 - Sequence 88467 from Patent EP1572962.
JD252301 - Sequence 233325 from Patent EP1572962.
JD085833 - Sequence 66857 from Patent EP1572962.
JD205663 - Sequence 186687 from Patent EP1572962.
JD373836 - Sequence 354860 from Patent EP1572962.
JD470610 - Sequence 451634 from Patent EP1572962.
JD310999 - Sequence 292023 from Patent EP1572962.
JD097860 - Sequence 78884 from Patent EP1572962.

-  Biochemical and Signaling Pathways
  Reactome (by CSHL, EBI, and GO)

Protein Q08708 (Reactome details) participates in the following event(s):

R-HSA-5696358 TREM,CD300 binds lipids
R-HSA-198933 Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell
R-HSA-1280218 Adaptive Immune System
R-HSA-168256 Immune System

-  Other Names for This Gene
  Alternate Gene Symbols: CLM6_HUMAN, CMRF35, CMRF35A, CMRF35A1, ENST00000330793.1, IGSF16, NM_006678, Q08708, uc002jky.1, uc002jky.2, uc002jky.3, uc002jky.4
UCSC ID: ENST00000330793.2
RefSeq Accession: NM_006678.5
Protein: Q08708 (aka CLM6_HUMAN)
CCDS: CCDS11701.1

-  Methods, Credits, and Use Restrictions
  Click here for details on how this gene model was made and data restrictions if any.