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Human Gene CD300LF (ENST00000326165.11) from GENCODE V50
  Description: CD300 molecule like family member f, transcript variant 1 (from RefSeq NM_139018.5)
Gencode Transcript: ENST00000326165.11
Gencode Gene: ENSG00000186074.21
Transcript (Including UTRs)
   Position: hg38 chr17:74,694,317-74,712,923 Size: 18,607 Total Exon Count: 7 Strand: -
Coding Region
   Position: hg38 chr17:74,695,096-74,712,866 Size: 17,771 Coding Exon Count: 7 

Page IndexSequence and LinksUniProtKB CommentsPrimersCTDRNA-Seq Expression
RNA StructureProtein StructureOther SpeciesGO AnnotationsmRNA DescriptionsPathways
Other NamesMethods
Data last updated at UCSC: 2026-07-12 09:30:09

-  Comments and Description Text from UniProtKB
  ID: CLM1_HUMAN
DESCRIPTION: RecName: Full=CMRF35-like molecule 1; Short=CLM-1; AltName: Full=CD300 antigen-like family member F; AltName: Full=Immune receptor expressed on myeloid cells 1; Short=IREM-1; AltName: Full=Immunoglobulin superfamily member 13; Short=IgSF13; AltName: Full=NK inhibitory receptor; AltName: CD_antigen=CD300f; Flags: Precursor;
FUNCTION: Acts as an inhibitory receptor for myeloid cells and mast cells. Inhibits osteoclast formation.
SUBUNIT: Interacts with PTPN6/SHP-1 in a tyrosine phosphorylation dependent manner.
SUBCELLULAR LOCATION: Cell membrane; Single-pass type I membrane protein (Potential).
TISSUE SPECIFICITY: Highly expressed in spleen, peripheral blood leukocyte and monocyte, and lung. Weakly expressed in thymus, heart, brain, placenta, liver, skeletal muscle, kidney, pancreas, prostate, testis, ovary, small intestine or colon. Expressed selectively in monocytes and monocyte-related cells.
PTM: Phosphorylated on tyrosine.
SIMILARITY: Belongs to the CD300 family.
SIMILARITY: Contains 1 Ig-like V-type (immunoglobulin-like) domain.

-  Primer design for this transcript
 

Primer3Plus can design qPCR Primers that straddle exon-exon-junctions, which amplify only cDNA, not genomic DNA.
Click here to load the transcript sequence and exon structure into Primer3Plus

Exonprimer can design one pair of Sanger sequencing primers around every exon, located in non-genic sequence.
Click here to open Exonprimer with this transcript

To design primers for a non-coding sequence, zoom to a region of interest and select from the drop-down menu: View > In External Tools > Primer3


-  Comparative Toxicogenomics Database (CTD)
  The following chemicals interact with this gene           more ... click here to view the complete list

-  RNA-Seq Expression Data from GTEx (53 Tissues, 570 Donors)
  Highest median expression: 31.80 RPKM in Whole Blood
Total median expression: 79.06 RPKM



View in GTEx track of Genome Browser    View at GTEx portal     View GTEx Body Map

-  mRNA Secondary Structure of 3' and 5' UTRs
 
RegionFold EnergyBasesEnergy/Base
Display As
5' UTR -14.8057-0.260 Picture PostScript Text
3' UTR -262.50779-0.337 Picture PostScript Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

-  Protein Domain and Structure Information
  InterPro Domains: Graphical view of domain structure
IPR007110 - Ig-like
IPR013783 - Ig-like_fold
IPR003599 - Ig_sub
IPR013106 - Ig_V-set

Pfam Domains:
PF07686 - Immunoglobulin V-set domain

Protein Data Bank (PDB) 3-D Structure
MuPIT help
2NMS - X-ray MuPIT


ModBase Predicted Comparative 3D Structure on Q8TDQ1
FrontTopSide
The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.

-  Orthologous Genes in Other Species
  Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
MouseRatZebrafishD. melanogasterC. elegansS. cerevisiae
Genome BrowserGenome BrowserNo orthologNo orthologNo orthologNo ortholog
Gene Details     
Gene Sorter     
MGIRGD    
Protein SequenceProtein Sequence    
AlignmentAlignment    

-  Gene Ontology (GO) Annotations with Structured Vocabulary
  Molecular Function:
GO:0001786 phosphatidylserine binding
GO:0005136 interleukin-4 receptor binding
GO:0008289 lipid binding
GO:0097001 ceramide binding

Biological Process:
GO:0002376 immune system process
GO:0033004 negative regulation of mast cell activation
GO:0034125 negative regulation of MyD88-dependent toll-like receptor signaling pathway
GO:0035666 TRIF-dependent toll-like receptor signaling pathway
GO:0035772 interleukin-13-mediated signaling pathway
GO:0050776 regulation of immune response
GO:1902216 positive regulation of interleukin-4-mediated signaling pathway
GO:2000426 negative regulation of apoptotic cell clearance
GO:2000427 positive regulation of apoptotic cell clearance

Cellular Component:
GO:0005886 plasma membrane
GO:0016020 membrane
GO:0016021 integral component of membrane


-  Descriptions from all associated GenBank mRNAs
  AF251706 - Homo sapiens NK inhibitory receptor precursor (NKIR) mRNA, complete cds.
AY358545 - Homo sapiens clone DNA125200 PIGR (UNQ3105) mRNA, complete cds.
BC028199 - Homo sapiens CD300 molecule-like family member f, mRNA (cDNA clone MGC:40116 IMAGE:5207520), complete cds.
AK092757 - Homo sapiens cDNA FLJ35438 fis, clone SMINT2002884, weakly similar to CMRF35 ANTIGEN PRECURSOR.
AX747710 - Sequence 1235 from Patent EP1308459.
AK298752 - Homo sapiens cDNA FLJ52935 complete cds, highly similar to CMRF35-like-molecule 1 precursor.
AY303545 - Homo sapiens inhibitory receptor IREM1 (IREM1) mRNA, complete cds.
AK315165 - Homo sapiens cDNA, FLJ96140, highly similar to Homo sapiens NK inhibitory receptor precursor (NKIR), mRNA.
JD151152 - Sequence 132176 from Patent EP1572962.
JD250755 - Sequence 231779 from Patent EP1572962.
JD148631 - Sequence 129655 from Patent EP1572962.
JD516139 - Sequence 497163 from Patent EP1572962.
JD038191 - Sequence 19215 from Patent EP1572962.
JD092257 - Sequence 73281 from Patent EP1572962.
JD473051 - Sequence 454075 from Patent EP1572962.
JD508705 - Sequence 489729 from Patent EP1572962.
JD053532 - Sequence 34556 from Patent EP1572962.
JD157316 - Sequence 138340 from Patent EP1572962.
AF375480 - Homo sapiens immune receptor expressed on myeloid cells splice variant 1 (IREM1) mRNA, complete cds; alternatively spliced.
AF375481 - Homo sapiens immune receptor expressed on myeloid cells splice variant 2 (IREM1) mRNA, complete cds; alternatively spliced.
JD341665 - Sequence 322689 from Patent EP1572962.
JD370654 - Sequence 351678 from Patent EP1572962.
JD385802 - Sequence 366826 from Patent EP1572962.
KJ905002 - Synthetic construct Homo sapiens clone ccsbBroadEn_14396 CD300LF gene, encodes complete protein.
DQ153249 - Homo sapiens unknown mRNA.

-  Biochemical and Signaling Pathways
  Reactome (by CSHL, EBI, and GO)

Protein Q8TDQ1 (Reactome details) participates in the following event(s):

R-HSA-5696358 TREM,CD300 binds lipids
R-HSA-198933 Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell
R-HSA-1280218 Adaptive Immune System
R-HSA-168256 Immune System

-  Other Names for This Gene
  Alternate Gene Symbols: B2RCL2, C9JDN3, CD300F, CLM1, CLM1_HUMAN, ENST00000326165.1, ENST00000326165.10, ENST00000326165.2, ENST00000326165.3, ENST00000326165.4, ENST00000326165.5, ENST00000326165.6, ENST00000326165.7, ENST00000326165.8, ENST00000326165.9, IGSF13, IREM1, NKIR, NM_139018, Q3Y6P0, Q6UX24, Q7Z6A6, Q7Z7I4, Q7Z7I5, Q8N6D0, Q8NAF5, Q8TDQ1, uc002jlg.1, uc002jlg.2, uc002jlg.3, uc002jlg.4, uc002jlg.5, uc002jlg.6, UNQ3105/PRO10111
UCSC ID: ENST00000326165.11
RefSeq Accession: NM_139018.5
Protein: Q8TDQ1 (aka CLM1_HUMAN)
CCDS: CCDS11704.1, CCDS74152.1

-  Methods, Credits, and Use Restrictions
  Click here for details on how this gene model was made and data restrictions if any.