Human Gene CD84 (ENST00000368054.7) Description and Page Index
Description: Homo sapiens CD84 molecule (CD84), transcript variant 2, mRNA. (from RefSeq NM_003874) RefSeq Summary (NM_003874): This gene encodes a membrane glycoprotein that is a member of the signaling lymphocyte activation molecule (SLAM) family. This family forms a subset of the larger CD2 cell-surface receptor Ig superfamily. The encoded protein is a homophilic adhesion molecule that is expressed in numerous immune cells types and is involved in regulating receptor-mediated signaling in those cells. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Oct 2011]. Gencode Transcript: ENST00000368054.7 Gencode Gene: ENSG00000066294.14 Transcript (Including UTRs) Position: hg38 chr1:160,541,098-160,579,473 Size: 38,376 Total Exon Count: 7 Strand: - Coding Region Position: hg38 chr1:160,548,256-160,579,437 Size: 31,182 Coding Exon Count: 7
ID:SLAF5_HUMAN DESCRIPTION: RecName: Full=SLAM family member 5; AltName: Full=Cell surface antigen MAX.3; AltName: Full=Hly9-beta; AltName: Full=Leukocyte differentiation antigen CD84; AltName: Full=Signaling lymphocytic activation molecule 5; AltName: CD_antigen=CD84; Flags: Precursor; FUNCTION: Plays a role as adhesion receptor functioning by homophilic interactions and by clustering. Recruits SH2 domain- containing proteins SH2D1A/SAP. Increases proliferative responses of activated T-cells and SH2D1A/SAP does not seen be required for this process. Homophilic interactions enhance interferon gamma/IFNG secretion in lymphocytes and induce platelet stimulation via a SH2D1A/SAP-dependent pathway. May serve as a marker for hematopoietic progenitor cells. SUBUNIT: Homodimer; via its extracellular domain. Forms a head to tail dimer with a CD48 molecule from another cell. Interacts with SH2 domain-containing proteins SH2D1A/SAP and SH2D1B/hEAT-2. Interacts with tyrosine-protein phosphatases PTPN6 and PTPN11 via its phosphorylated cytoplasmic domain, and this interaction is blocked by SH2D1A. SUBCELLULAR LOCATION: Cell membrane; Single-pass type I membrane protein. TISSUE SPECIFICITY: Predominantly expressed in hematopoietic tissues, such as lymph node, spleen and peripheral leukocytes. Expressed in macrophages, B-cells, monocytes, platelets, thymocytes, T-cells and dendritic cells. Highly expressed in memory T-cells. DEVELOPMENTAL STAGE: Expression is slightly increased in naive B- cells after the first dividion. By contrast, expression on memory B-cells decreased with each successive division. DOMAIN: ITSM (immunoreceptor tyrosine-based switch motif) motif is a cytoplasmic motif which may bind SH2D1A. PTM: Phosphorylated by tyrosine-protein kinase LCK on tyrosine residues following ligation induced by agonist monoclonal antibody. The association with SH2D1A/SAP is dependent of tyrosines phosphorylation of its cytoplasmic domain Phosphorylated on Tyr-296 and Tyr-316 following platelet aggregation. PTM: N-glycosylated. SIMILARITY: Contains 1 Ig-like C2-type (immunoglobulin-like) domain.
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
ModBase Predicted Comparative 3D Structure on Q9UIB8
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.