Human Gene CDC45 (ENST00000263201.7) from GENCODE V44
Description: Homo sapiens cell division cycle 45 (CDC45), transcript variant 2, mRNA. (from RefSeq NM_003504) RefSeq Summary (NM_003504): The protein encoded by this gene was identified by its strong similarity with Saccharomyces cerevisiae Cdc45, an essential protein required to the initiation of DNA replication. Cdc45 is a member of the highly conserved multiprotein complex including Cdc6/Cdc18, the minichromosome maintenance proteins (MCMs) and DNA polymerase, which is important for early steps of DNA replication in eukaryotes. This protein has been shown to interact with MCM7 and DNA polymerase alpha. Studies of the similar gene in Xenopus suggested that this protein play a pivotal role in the loading of DNA polymerase alpha onto chromatin. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Jul 2013]. Sequence Note: The RefSeq transcript and protein were derived from genomic sequence to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on alignments. Gencode Transcript: ENST00000263201.7 Gencode Gene: ENSG00000093009.11 Transcript (Including UTRs) Position: hg38 chr22:19,479,920-19,520,608 Size: 40,689 Total Exon Count: 19 Strand: + Coding Region Position: hg38 chr22:19,479,969-19,518,908 Size: 38,940 Coding Exon Count: 18
ID:CDC45_HUMAN DESCRIPTION: RecName: Full=Cell division control protein 45 homolog; AltName: Full=PORC-PI-1; FUNCTION: Required for initiation of chromosomal DNA replication. SUBUNIT: Associated with ORC2. INTERACTION: Q92547:TOPBP1; NbExp=6; IntAct=EBI-374969, EBI-308302; SUBCELLULAR LOCATION: Cytoplasm. Nucleus. TISSUE SPECIFICITY: Widely expressed, highest levels are found in adult testis and thymus and in fetal liver. DEVELOPMENTAL STAGE: Transcript peaks at G1-S transition, but total protein remains constant throughout the cell cycle. Expressed in multiple tissues during embryogenesis, including neural crest-derived structures. SIMILARITY: Belongs to the CDC45 family. WEB RESOURCE: Name=NIEHS-SNPs; URL="http://egp.gs.washington.edu/data/cdc45l/";
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
ModBase Predicted Comparative 3D Structure on O75419
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.