Human Gene CDH4 (ENST00000614565.5) from GENCODE V44
Description: Homo sapiens cadherin 4 (CDH4), transcript variant 1, mRNA. (from RefSeq NM_001794) RefSeq Summary (NM_001794): This gene is a classical cadherin from the cadherin superfamily. The encoded protein is a calcium-dependent cell-cell adhesion glycoprotein comprised of five extracellular cadherin repeats, a transmembrane region and a highly conserved cytoplasmic tail. Based on studies in chicken and mouse, this cadherin is thought to play an important role during brain segmentation and neuronal outgrowth. In addition, a role in kidney and muscle development is indicated. Of particular interest are studies showing stable cis-heterodimers of cadherins 2 and 4 in cotransfected cell lines. Previously thought to interact in an exclusively homophilic manner, this is the first evidence of cadherin heterodimerization. Three transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Nov 2011]. Gencode Transcript: ENST00000614565.5 Gencode Gene: ENSG00000179242.16 Transcript (Including UTRs) Position: hg38 chr20:61,252,261-61,940,617 Size: 688,357 Total Exon Count: 16 Strand: + Coding Region Position: hg38 chr20:61,252,514-61,936,943 Size: 684,430 Coding Exon Count: 16
ID:CADH4_HUMAN DESCRIPTION: RecName: Full=Cadherin-4; AltName: Full=Retinal cadherin; Short=R-CAD; Short=R-cadherin; Flags: Precursor; FUNCTION: Cadherins are calcium-dependent cell adhesion proteins. They preferentially interact with themselves in a homophilic manner in connecting cells; cadherins may thus contribute to the sorting of heterogeneous cell types. May play an important role in retinal development. SUBCELLULAR LOCATION: Cell membrane; Single-pass type I membrane protein. TISSUE SPECIFICITY: Expressed mainly in brain but also found in other tissues. SIMILARITY: Contains 5 cadherin domains.
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
Pfam Domains: PF00028 - Cadherin domain PF01049 - Cadherin cytoplasmic region PF08758 - Cadherin prodomain like
ModBase Predicted Comparative 3D Structure on P55283
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
US Server
