Human Gene CDK4 (ENST00000257904.11) from GENCODE V44
  Description: Homo sapiens cyclin dependent kinase 4 (CDK4), mRNA. (from RefSeq NM_000075)
RefSeq Summary (NM_000075): The protein encoded by this gene is a member of the Ser/Thr protein kinase family. This protein is highly similar to the gene products of S. cerevisiae cdc28 and S. pombe cdc2. It is a catalytic subunit of the protein kinase complex that is important for cell cycle G1 phase progression. The activity of this kinase is restricted to the G1-S phase, which is controlled by the regulatory subunits D-type cyclins and CDK inhibitor p16(INK4a). This kinase was shown to be responsible for the phosphorylation of retinoblastoma gene product (Rb). Mutations in this gene as well as in its related proteins including D-type cyclins, p16(INK4a) and Rb were all found to be associated with tumorigenesis of a variety of cancers. Multiple polyadenylation sites of this gene have been reported. [provided by RefSeq, Jul 2008]. Sequence Note: This RefSeq record was created from transcript and genomic sequence data to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on transcript alignments.
Gencode Transcript: ENST00000257904.11
Gencode Gene: ENSG00000135446.17
Transcript (Including UTRs)
   Position: hg38 chr12:57,747,727-57,752,310 Size: 4,584 Total Exon Count: 8 Strand: -
Coding Region
   Position: hg38 chr12:57,748,525-57,751,717 Size: 3,193 Coding Exon Count: 7 

Page IndexSequence and LinksUniProtKB CommentsPrimersMalaCardsCTD
RNA-Seq ExpressionMicroarray ExpressionRNA StructureProtein StructureOther SpeciesGO Annotations
mRNA DescriptionsPathwaysOther NamesMethods
Data last updated at UCSC: 2023-08-18 00:09:47

-  Sequence and Links to Tools and Databases
 
Genomic Sequence (chr12:57,747,727-57,752,310)mRNA (may differ from genome)Protein (303 aa)
Gene SorterGenome BrowserOther Species FASTAGene interactionsTable SchemaAlphaFold
BioGPSEnsemblEntrez GeneExonPrimerGencodeGeneCards
HGNCHPRDLynxMalacardsMGIneXtProt
OMIMPubMedReactomeUniProtKBWikipediaBioGrid CRISPR DB

-  Comments and Description Text from UniProtKB
  ID: CDK4_HUMAN
DESCRIPTION: RecName: Full=Cyclin-dependent kinase 4; EC=2.7.11.22; AltName: Full=Cell division protein kinase 4; AltName: Full=PSK-J3;
FUNCTION: Ser/Thr-kinase component of cyclin D-CDK4 (DC) complexes that phosphorylate and inhibit members of the retinoblastoma (RB) protein family including RB1 and regulate the cell-cycle during G(1)/S transition. Phosphorylation of RB1 allows dissociation of the transcription factor E2F from the RB/E2F complexes and the subsequent transcription of E2F target genes which are responsible for the progression through the G(1) phase. Hypophosphorylates RB1 in early G(1) phase. Cyclin D-CDK4 complexes are major integrators of various mitogenenic and antimitogenic signals. Also phosphorylates SMAD3 in a cell-cycle-dependent manner and represses its transcriptional activity. Component of the ternary complex, cyclin D/CDK4/CDKN1B, required for nuclear translocation and activity of the cyclin D-CDK4 complex.
CATALYTIC ACTIVITY: ATP + a protein = ADP + a phosphoprotein.
ENZYME REGULATION: Both phosphorylation at Thr-172 and binding of a D-type cyclin are necessary for enzymatic activity. Full activation of the cyclin-D-CDK4 complex appears to require other factors such as recruitment of the substrate via a substrate recruitment motif, and/or formation of the CDKN1B ternary complex. Inhibited by INK4 family members. In resting cells, the non- tyrosine-phosphorylated form of CDKN1B prevents phosphorylation at Thr-172 and inactivation, while, in proliferating cells, tyrosine phosphorylation of CDKN1B allows phosphorylation of Thr-172 of CDK4 and subsequennt activation.
SUBUNIT: Component of the D-CDK4 complex, composed of CDK4 and some D-type G1 cyclin (CCND1, CCND2 or CCND3). Interacts directly in the complex with CCND1, CCND2 or CCND3. Interacts with SEI1 and ZNF655. Forms a ternary complex, cyclin D-CDK4-CDKN1B, involved in modulating CDK4 enzymatic activity. Interacts directly with CDKN1B (phosphorylated on 'Tyr-88' and 'Tyr-89'); the interaction allows assembly of the cyclin D-CDK4 complex, Thr-172 phosphorylation, nuclear translocation and enhances the cyclin D-CDK4 complex activity. CDK4 activity is either inhibited or enhanced depending on stoichiometry of complex. The non-tyrosine-phosphorylated form of CDKN1B prevents T-loop phosphosphorylation of CDK4 producing inactive CDK4. Interacts (unphosphorylated form) with CDK2. Also forms ternary complexes with CDKN1A or CDKN2A. Interacts directly with CDKN1A (via its N-terminal); the interaction promotes the assembly of the cyclin D-CDK4 complex, its nuclear translocation and promotes the cyclin D-dependent enzyme activity of CDK4.
INTERACTION: P24385:CCND1; NbExp=10; IntAct=EBI-295644, EBI-375001; P30281:CCND3; NbExp=6; IntAct=EBI-295644, EBI-375013; Q16543:CDC37; NbExp=5; IntAct=EBI-295644, EBI-295634; P38936:CDKN1A; NbExp=4; IntAct=EBI-295644, EBI-375077; P46527:CDKN1B; NbExp=2; IntAct=EBI-295644, EBI-519280; P42771:CDKN2A; NbExp=7; IntAct=EBI-295644, EBI-375053; P42772:CDKN2B; NbExp=3; IntAct=EBI-295644, EBI-711280; P01106:MYC; NbExp=2; IntAct=EBI-295644, EBI-447544; P28749:RBL1; NbExp=2; IntAct=EBI-295644, EBI-971402; Q8N720:ZNF655; NbExp=3; IntAct=EBI-295644, EBI-625509;
SUBCELLULAR LOCATION: Cytoplasm. Nucleus. Membrane. Note=Cytoplasmic when non-complexed. Forms a cyclin D-CDK4 complex in the cytoplasm as cells progress through G(1) phase. The complex accumulates on the nuclear membrane and enters the nucleus on transition from G(1) to S phase. Also present in nucleoli and heterochromatin lumps. Colocalizes with RB1 after release into the nucleus.
PTM: Phosphorylation at Thr-172 is required for enzymatic activity. Phosphorylated, in vitro, at this site by CCNH-CDK7, but, in vivo, appears to be phosphorylated by a proline-directed kinase. In the cyclin D-CDK4-CDKN1B complex, this phosphorylation and consequent CDK4 enzyme activity, is dependent on the tyrosine phosphorylation state of CDKN1B. Thus, in proliferating cells, CDK4 within the complex is phosphorylated on Thr-172 in the T- loop. In resting cells, phosphorylation on Thr-172 is prevented by the non-tyrosine-phosphorylated form of CDKN1B.
DISEASE: Defects in CDK4 are a cause of susceptibility to cutaneous malignant melanoma type 3 (CMM3) [MIM:609048]. Malignant melanoma is a malignant neoplasm of melanocytes, arising de novo or from a pre-existing benign nevus, which occurs most often in the skin but also may involve other sites.
SIMILARITY: Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. CDC2/CDKX subfamily.
SIMILARITY: Contains 1 protein kinase domain.
WEB RESOURCE: Name=Atlas of Genetics and Cytogenetics in Oncology and Haematology; URL="http://atlasgeneticsoncology.org/Genes/CDK4ID238ch12q14.html";
WEB RESOURCE: Name=GeneReviews; URL="http://www.ncbi.nlm.nih.gov/sites/GeneTests/lab/gene/CDK4";
WEB RESOURCE: Name=NIEHS-SNPs; URL="http://egp.gs.washington.edu/data/cdk4/";

-  Primer design for this transcript
 

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-  MalaCards Disease Associations
  MalaCards Gene Search: CDK4
Diseases sorted by gene-association score: melanoma, cutaneous malignant, 3* (905), cdk4-related cutaneous malignant melanoma* (125), dedifferentiated liposarcoma* (38), atypical lipomatous tumor* (36), retinoblastoma (24), melanoma (18), astrocytoma (18), ring chromosome 7 (17), glioblastoma (17), malignant melanoma, somatic* (16), liposarcoma (16), lung cancer (16), multiple myeloma (14), lung cancer susceptibility 3 (13), myxoid liposarcoma (13), undifferentiated embryonal sarcoma of the liver (13), lipomatosis, multiple (12), peripheral osteosarcoma (12), diffuse large b-cell lymphoma (11), retinal cancer (11), sensory system cancer (11), glioblastoma multiforme (11), glioblastoma proneural subtype (11), spindle cell liposarcoma (10), lipoblastoma (10), juxtacortical osteosarcoma (9), bone osteosarcoma (9), esophageal cancer (9), mixed liposarcoma (9), infiltrating angiolipoma (8), cornea cancer (8), extraosseous osteosarcoma (8), uveal melanoma (8), leiomyosarcoma (8), malignant glioma (8), ocular cancer (7), star syndrome (7), grade iii astrocytoma (7), embryonal rhabdomyosarcoma (7), malignant fibrous histiocytoma of bone (7), ewing's family of tumors (7), spindle cell lipoma (6), rhabdomyosarcoma 2, alveolar (6), inflammatory mfh (6), chondroid lipoma (6), malignant peripheral nerve sheath tumor (6), periosteal osteogenic sarcoma (6), connective tissue cancer (6), nervous system cancer (6), skeletal muscle cancer (6), histiocytoma (6), osteosarcoma, somatic (6), ischemic fasciitis (5), breast cancer (5), periosteal chondrosarcoma (5), carbuncle (5), embryonal sarcoma (5), malignant mesenchymoma (5), pleomorphic lipoma (5), small cell sarcoma (5), infiltrating lipoma (5), pancreatic cancer (4), glioma (4), liver angiosarcoma (4), skin sarcoma (4), fibrosarcoma of bone (4), griscelli syndrome, type 1 (4), breast secretory carcinoma (4), gliosarcoma (4), endometrial cancer (4), rhabdomyosarcoma (3), prostate cancer (3), mantle cell lymphoma (3), nasopharyngeal carcinoma (3), hepatocellular carcinoma (3), colorectal cancer (2), ovarian cancer, somatic (2), urinary bladder cancer (2), pilocytic astrocytoma (2), cell type cancer (1)
* = Manually curated disease association

-  Comparative Toxicogenomics Database (CTD)
  The following chemicals interact with this gene           more ... click here to view the complete list

-  RNA-Seq Expression Data from GTEx (53 Tissues, 570 Donors)
  Highest median expression: 59.06 RPKM in Cells - EBV-transformed lymphocytes
Total median expression: 1139.56 RPKM



View in GTEx track of Genome Browser    View at GTEx portal     View GTEx Body Map

+  Microarray Expression Data
  Press "+" in the title bar above to open this section.

-  mRNA Secondary Structure of 3' and 5' UTRs
 
RegionFold EnergyBasesEnergy/Base
Display As
5' UTR -73.50155-0.474 Picture PostScript Text
3' UTR -249.90798-0.313 Picture PostScript Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

-  Protein Domain and Structure Information
  InterPro Domains: Graphical view of domain structure
IPR011009 - Kinase-like_dom
IPR000719 - Prot_kinase_cat_dom
IPR017441 - Protein_kinase_ATP_BS
IPR002290 - Ser/Thr_dual-sp_kinase_dom
IPR008271 - Ser/Thr_kinase_AS

Pfam Domains:
PF00069 - Protein kinase domain

Protein Data Bank (PDB) 3-D Structure
MuPIT help
1LD2 - Model 2W96 - X-ray MuPIT 2W99 - X-ray MuPIT 2W9F - X-ray MuPIT 2W9Z - X-ray MuPIT 3G33 - X-ray MuPIT


ModBase Predicted Comparative 3D Structure on P11802
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The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.

-  Orthologous Genes in Other Species
  Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
MouseRatZebrafishD. melanogasterC. elegansS. cerevisiae
Genome BrowserGenome BrowserGenome BrowserNo orthologNo orthologNo ortholog
Gene Details     
Gene Sorter     
MGIRGDEnsembl   
Protein SequenceProtein SequenceProtein Sequence   
AlignmentAlignmentAlignment   

-  Gene Ontology (GO) Annotations with Structured Vocabulary
  Molecular Function:
GO:0000166 nucleotide binding
GO:0004672 protein kinase activity
GO:0004674 protein serine/threonine kinase activity
GO:0004693 cyclin-dependent protein serine/threonine kinase activity
GO:0005515 protein binding
GO:0005524 ATP binding
GO:0016301 kinase activity
GO:0016538 cyclin-dependent protein serine/threonine kinase regulator activity
GO:0016740 transferase activity
GO:0030332 cyclin binding
GO:0044877 macromolecular complex binding

Biological Process:
GO:0000082 G1/S transition of mitotic cell cycle
GO:0002088 lens development in camera-type eye
GO:0006367 transcription initiation from RNA polymerase II promoter
GO:0006468 protein phosphorylation
GO:0007049 cell cycle
GO:0007165 signal transduction
GO:0007275 multicellular organism development
GO:0007623 circadian rhythm
GO:0008284 positive regulation of cell proliferation
GO:0009636 response to toxic substance
GO:0010033 response to organic substance
GO:0010288 response to lead ion
GO:0010468 regulation of gene expression
GO:0010971 positive regulation of G2/M transition of mitotic cell cycle
GO:0016310 phosphorylation
GO:0031100 animal organ regeneration
GO:0031658 negative regulation of cyclin-dependent protein serine/threonine kinase activity involved in G1/S transition of mitotic cell cycle
GO:0032869 cellular response to insulin stimulus
GO:0033574 response to testosterone
GO:0040014 regulation of multicellular organism growth
GO:0042127 regulation of cell proliferation
GO:0042493 response to drug
GO:0043065 positive regulation of apoptotic process
GO:0045727 positive regulation of translation
GO:0045787 positive regulation of cell cycle
GO:0045793 positive regulation of cell size
GO:0046626 regulation of insulin receptor signaling pathway
GO:0046890 regulation of lipid biosynthetic process
GO:0048146 positive regulation of fibroblast proliferation
GO:0050994 regulation of lipid catabolic process
GO:0051301 cell division
GO:0051726 regulation of cell cycle
GO:0055093 response to hyperoxia
GO:0060612 adipose tissue development
GO:0071157 negative regulation of cell cycle arrest
GO:0071222 cellular response to lipopolysaccharide
GO:0071353 cellular response to interleukin-4
GO:1904628 cellular response to phorbol 13-acetate 12-myristate
GO:1904637 cellular response to ionomycin

Cellular Component:
GO:0000307 cyclin-dependent protein kinase holoenzyme complex
GO:0000785 chromatin
GO:0005634 nucleus
GO:0005654 nucleoplasm
GO:0005667 transcription factor complex
GO:0005730 nucleolus
GO:0005737 cytoplasm
GO:0005829 cytosol
GO:0005923 bicellular tight junction
GO:0016020 membrane
GO:0031965 nuclear membrane
GO:0032991 macromolecular complex
GO:0048471 perinuclear region of cytoplasm
GO:0097129 cyclin D2-CDK4 complex


-  Descriptions from all associated GenBank mRNAs
  LF208919 - JP 2014500723-A/16422: Polycomb-Associated Non-Coding RNAs.
MA444496 - JP 2018138019-A/16422: Polycomb-Associated Non-Coding RNAs.
LF208918 - JP 2014500723-A/16421: Polycomb-Associated Non-Coding RNAs.
MA444495 - JP 2018138019-A/16421: Polycomb-Associated Non-Coding RNAs.
BC003644 - Homo sapiens cyclin-dependent kinase 4, mRNA (cDNA clone MGC:4678 IMAGE:3532812), complete cds.
BC010153 - Homo sapiens cyclin-dependent kinase 4, mRNA (cDNA clone MGC:19704 IMAGE:3531300), complete cds.
BC005864 - Homo sapiens cyclin-dependent kinase 4, mRNA (cDNA clone MGC:3719 IMAGE:2961345), complete cds.
Z48970 - H.sapiens mRNA (open reading frame; patient SK29(AV)).
U79269 - Human cyclin-dependent protein kinase mRNA, complete cds.
LF324092 - JP 2014500723-A/131595: Polycomb-Associated Non-Coding RNAs.
MA559669 - JP 2018138019-A/131595: Polycomb-Associated Non-Coding RNAs.
BC015669 - Homo sapiens cyclin-dependent kinase 4, mRNA (cDNA clone IMAGE:4139521), complete cds.
M14505 - Human (clone PSK-J3) cyclin-dependent protein kinase mRNA, complete cds.
DM110832 - Novel Cancer Marker and Use Thereof.
JD048549 - Sequence 29573 from Patent EP1572962.
JD533343 - Sequence 514367 from Patent EP1572962.
JD450523 - Sequence 431547 from Patent EP1572962.
JD086263 - Sequence 67287 from Patent EP1572962.
JD047851 - Sequence 28875 from Patent EP1572962.
HI463878 - Sequence 23 from Patent EP2124967.
JD170662 - Sequence 151686 from Patent EP1572962.
JD448973 - Sequence 429997 from Patent EP1572962.
AK297901 - Homo sapiens cDNA FLJ60730 complete cds, highly similar to Cell division protein kinase 4 (EC 2.7.11.22).
CR542247 - Homo sapiens full open reading frame cDNA clone RZPDo834A0426D for gene CDK4, cyclin-dependent kinase 4; complete cds, incl. stopcodon.
AK313701 - Homo sapiens cDNA, FLJ94294, highly similar to Homo sapiens cyclin-dependent kinase 4 (CDK4), mRNA.
KJ890883 - Synthetic construct Homo sapiens clone ccsbBroadEn_00277 CDK4 gene, encodes complete protein.
KJ905164 - Synthetic construct Homo sapiens clone ccsbBroadEn_14574 CDK4 gene, encodes complete protein.
KR709911 - Synthetic construct Homo sapiens clone CCSBHm_00007693 CDK4 (CDK4) mRNA, encodes complete protein.
KR709912 - Synthetic construct Homo sapiens clone CCSBHm_00007694 CDK4 (CDK4) mRNA, encodes complete protein.
KR709913 - Synthetic construct Homo sapiens clone CCSBHm_00007695 CDK4 (CDK4) mRNA, encodes complete protein.
KR709914 - Synthetic construct Homo sapiens clone CCSBHm_00007696 CDK4 (CDK4) mRNA, encodes complete protein.
DQ893137 - Synthetic construct clone IMAGE:100005767; FLH194154.01X; RZPDo839F1279D cyclin-dependent kinase 4 (CDK4) gene, encodes complete protein.
DQ896420 - Synthetic construct Homo sapiens clone IMAGE:100010880; FLH194150.01L; RZPDo839F1269D cyclin-dependent kinase 4 (CDK4) gene, encodes complete protein.
AB528330 - Synthetic construct DNA, clone: pF1KB7613, Homo sapiens CDK4 gene for cyclin-dependent kinase 4, without stop codon, in Flexi system.
CR407668 - Homo sapiens full open reading frame cDNA clone RZPDo834B043D for gene CDK4, cyclin-dependent kinase 4 complete cds, without stopcodon.
JD535271 - Sequence 516295 from Patent EP1572962.
JD259544 - Sequence 240568 from Patent EP1572962.
LF324090 - JP 2014500723-A/131593: Polycomb-Associated Non-Coding RNAs.
MA559667 - JP 2018138019-A/131593: Polycomb-Associated Non-Coding RNAs.
JD382624 - Sequence 363648 from Patent EP1572962.
AK310724 - Homo sapiens cDNA, FLJ17766.
LF324089 - JP 2014500723-A/131592: Polycomb-Associated Non-Coding RNAs.
MA559666 - JP 2018138019-A/131592: Polycomb-Associated Non-Coding RNAs.
LF324088 - JP 2014500723-A/131591: Polycomb-Associated Non-Coding RNAs.
MA559665 - JP 2018138019-A/131591: Polycomb-Associated Non-Coding RNAs.
LF324087 - JP 2014500723-A/131590: Polycomb-Associated Non-Coding RNAs.
MA559664 - JP 2018138019-A/131590: Polycomb-Associated Non-Coding RNAs.
LF324086 - JP 2014500723-A/131589: Polycomb-Associated Non-Coding RNAs.
MA559663 - JP 2018138019-A/131589: Polycomb-Associated Non-Coding RNAs.
JD232634 - Sequence 213658 from Patent EP1572962.
JD232633 - Sequence 213657 from Patent EP1572962.
JD477147 - Sequence 458171 from Patent EP1572962.
JD484797 - Sequence 465821 from Patent EP1572962.

-  Biochemical and Signaling Pathways
  KEGG - Kyoto Encyclopedia of Genes and Genomes
hsa04110 - Cell cycle
hsa04115 - p53 signaling pathway
hsa04530 - Tight junction
hsa04660 - T cell receptor signaling pathway
hsa05200 - Pathways in cancer
hsa05212 - Pancreatic cancer
hsa05214 - Glioma
hsa05218 - Melanoma
hsa05219 - Bladder cancer
hsa05220 - Chronic myeloid leukemia
hsa05222 - Small cell lung cancer
hsa05223 - Non-small cell lung cancer

BioCarta from NCI Cancer Genome Anatomy Project
h_rbPathway - RB Tumor Suppressor/Checkpoint Signaling in response to DNA damage
h_p53Pathway - p53 Signaling Pathway
h_g1Pathway - Cell Cycle: G1/S Check Point
h_EfpPathway - Estrogen-responsive protein Efp controls cell cycle and breast tumors growth
h_RacCycDPathway - Influence of Ras and Rho proteins on G1 to S Transition
h_cellcyclePathway - Cyclins and Cell Cycle Regulation

Reactome (by CSHL, EBI, and GO)

Protein P11802 (Reactome details) participates in the following event(s):

R-HSA-75822 Relocalization of nuclearly localized phospho-(T286):cyclin D1:Cdk4 to cytoplasm
R-HSA-182594 Association of INK4 with CDK4/6
R-HSA-8941895 Formation of CDK4/6:CCND complexes
R-HSA-75820 Phosphorylation of Cyclin D1 at T286 by glycogen synthase kinase-3 beta
R-HSA-3215426 COPRS binds CCND1:CDK4:PRMT5:pT5-WDR77
R-HSA-3215385 CDK4 in CCND1:CDK4:PRMT5:WDR77 phosphorylates WDR77
R-HSA-8941915 Cip/Kip CDK inhibitors bind CDK4/6:CCND complexes
R-HSA-9008412 CDK4 phosphorylates RUNX2
R-HSA-5205799 CCND1:CDK4:PRMT5:pT5-WDR77 methylates arginine-9 of histone H3 (H3R8)
R-HSA-5661117 CCND1:CDK4:PRMT5:pT5-WDR77 methylates methyl-arginine-9 of histone H3
R-HSA-8848414 Activated PTK6 binds CDKN1B
R-HSA-8848436 PTK6 phosphorylates CDKN1B
R-HSA-8942607 Tyrosine kinases phosphorylate Cip/Kip inhibitors bound to CDK4/6:CCND complexes
R-HSA-8942836 CDK4/6:CCND complexes are activated by T-loop phosphorylation of CDK4/6
R-HSA-5205861 COPRS:CCND1:CDK4:PRMT5:pT5-WDR77 methylates arginine-4 of histone H4 (H4R3)
R-HSA-69227 Cyclin D:CDK4/6 phosphorylates RB1 and prevents RB1 binding to E2F1/2/3:DP1/2 complexes
R-HSA-1226094 Cyclin D:Cdk4/6 mediated phosphorylation of p130 (RBL2) and dissociation of phosphorylated p130 (RBL2) from DP1:E2F4/5 complex
R-HSA-1226095 Cyclin D:CDK4/6 mediated phosphorylation of p107 (RBL1) and dissociation of phosphorylated p107 (p-RBL1) from DP1:E2F4 complex
R-HSA-912446 Meiotic recombination
R-HSA-69229 Ubiquitin-dependent degradation of Cyclin D1
R-HSA-69231 Cyclin D associated events in G1
R-HSA-2559580 Oxidative Stress Induced Senescence
R-HSA-2559582 Senescence-Associated Secretory Phenotype (SASP)
R-HSA-2559585 Oncogene Induced Senescence
R-HSA-3214858 RMTs methylate histone arginines
R-HSA-1500620 Meiosis
R-HSA-75815 Ubiquitin-dependent degradation of Cyclin D
R-HSA-69236 G1 Phase
R-HSA-2559583 Cellular Senescence
R-HSA-8878166 Transcriptional regulation by RUNX2
R-HSA-3247509 Chromatin modifying enzymes
R-HSA-1474165 Reproduction
R-HSA-1640170 Cell Cycle
R-HSA-187577 SCF(Skp2)-mediated degradation of p27/p21
R-HSA-8849470 PTK6 Regulates Cell Cycle
R-HSA-69242 S Phase
R-HSA-453279 Mitotic G1-G1/S phases
R-HSA-2262752 Cellular responses to stress
R-HSA-212436 Generic Transcription Pathway
R-HSA-4839726 Chromatin organization
R-HSA-69202 Cyclin E associated events during G1/S transition
R-HSA-69656 Cyclin A:Cdk2-associated events at S phase entry
R-HSA-8848021 Signaling by PTK6
R-HSA-69278 Cell Cycle (Mitotic)
R-HSA-8953897 Cellular responses to external stimuli
R-HSA-73857 RNA Polymerase II Transcription
R-HSA-69206 G1/S Transition
R-HSA-9006927 Signaling by Non-Receptor Tyrosine Kinases
R-HSA-74160 Gene expression (Transcription)
R-HSA-162582 Signal Transduction

-  Other Names for This Gene
  Alternate Gene Symbols: CDK4_HUMAN, ENST00000257904.1, ENST00000257904.10, ENST00000257904.2, ENST00000257904.3, ENST00000257904.4, ENST00000257904.5, ENST00000257904.6, ENST00000257904.7, ENST00000257904.8, ENST00000257904.9, NM_000075, O00576, P11802, Q6FG61, uc001spv.1, uc001spv.2, uc001spv.3, uc001spv.4, uc001spv.5
UCSC ID: ENST00000257904.11
RefSeq Accession: NM_000075
Protein: P11802 (aka CDK4_HUMAN)
CCDS: CCDS8953.1

-  Methods, Credits, and Use Restrictions
  Click here for details on how this gene model was made and data restrictions if any.