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Human Gene CDKL2 (ENST00000307465.9) from GENCODE V50
  Description: cyclin dependent kinase like 2, transcript variant 2 (from RefSeq NM_001330724.2)
Gencode Transcript: ENST00000307465.9
Gencode Gene: ENSG00000138769.13
Transcript (Including UTRs)
   Position: hg38 chr4:75,576,496-75,630,528 Size: 54,033 Total Exon Count: 14 Strand: -
Coding Region
   Position: hg38 chr4:75,581,833-75,625,988 Size: 44,156 Coding Exon Count: 12 

Page IndexSequence and LinksUniProtKB CommentsPrimersMalaCardsCTD
RNA-Seq ExpressionMicroarray ExpressionRNA StructureProtein StructureOther SpeciesGO Annotations
mRNA DescriptionsOther NamesMethods
Data last updated at UCSC: 2026-07-12 09:30:09

-  Comments and Description Text from UniProtKB
  ID: J3KNE8_HUMAN
DESCRIPTION: SubName: Full=Cyclin-dependent kinase-like 2;
CAUTION: The sequence shown here is derived from an Ensembl automatic analysis pipeline and should be considered as preliminary data.

-  Primer design for this transcript
 

Primer3Plus can design qPCR Primers that straddle exon-exon-junctions, which amplify only cDNA, not genomic DNA.
Click here to load the transcript sequence and exon structure into Primer3Plus

Exonprimer can design one pair of Sanger sequencing primers around every exon, located in non-genic sequence.
Click here to open Exonprimer with this transcript

To design primers for a non-coding sequence, zoom to a region of interest and select from the drop-down menu: View > In External Tools > Primer3


-  MalaCards Disease Associations
  MalaCards Gene Search: CDKL2
Diseases sorted by gene-association score: joubert syndrome 1 (1)

-  Comparative Toxicogenomics Database (CTD)
  The following chemicals interact with this gene           more ... click here to view the complete list

-  RNA-Seq Expression Data from GTEx (53 Tissues, 570 Donors)
  Highest median expression: 7.75 RPKM in Testis
Total median expression: 46.09 RPKM



View in GTEx track of Genome Browser    View at GTEx portal     View GTEx Body Map

+  Microarray Expression Data
 
Expression ratio colors:

GNF Expression Atlas 2 Data from U133A and GNF1H Chips

      
      
      
     
    
     
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-  mRNA Secondary Structure of 3' and 5' UTRs
 
RegionFold EnergyBasesEnergy/Base
Display As
5' UTR -199.70516-0.387 Picture PostScript Text
3' UTR -666.302706-0.246 Picture PostScript Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

-  Protein Domain and Structure Information
  InterPro Domains: Graphical view of domain structure
IPR011009 - Kinase-like_dom
IPR000719 - Prot_kinase_cat_dom
IPR017441 - Protein_kinase_ATP_BS
IPR002290 - Ser/Thr_dual-sp_kinase_dom
IPR008271 - Ser/Thr_kinase_AS

Pfam Domains:
PF00069 - Protein kinase domain

ModBase Predicted Comparative 3D Structure on J3KNE8
FrontTopSide
The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.

-  Orthologous Genes in Other Species
  Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
MouseRatZebrafishD. melanogasterC. elegansS. cerevisiae
Genome BrowserGenome BrowserNo orthologNo orthologNo orthologNo ortholog
Gene Details     
Gene Sorter     
MGIRGD    
Protein SequenceProtein Sequence    
AlignmentAlignment    

-  Gene Ontology (GO) Annotations with Structured Vocabulary
  Molecular Function:
GO:0004672 protein kinase activity
GO:0005524 ATP binding

Biological Process:
GO:0006468 protein phosphorylation

Cellular Component:
GO:0005634 nucleus
GO:0005813 centrosome


-  Descriptions from all associated GenBank mRNAs
  AK294866 - Homo sapiens cDNA FLJ56980 complete cds, highly similar to Cyclin-dependent kinase-like 2 (EC 2.7.11.22).
U35146 - Homo sapiens p56 KKIAMRE protein kinase (KKIAMRE) mRNA, complete cds.
BC093646 - Homo sapiens cyclin-dependent kinase-like 2 (CDC2-related kinase), mRNA (cDNA clone MGC:120681 IMAGE:7939491), complete cds.
BC093981 - Homo sapiens cyclin-dependent kinase-like 2 (CDC2-related kinase), mRNA (cDNA clone MGC:121016 IMAGE:7939826), complete cds.
HM005348 - Homo sapiens clone HTL-T-35 testicular tissue protein Li 35 mRNA, complete cds.
AK312490 - Homo sapiens cDNA, FLJ92851, Homo sapiens cyclin-dependent kinase-like 2 (CDC2-related kinase)(CDKL2), mRNA.
BC017417 - Homo sapiens cyclin-dependent kinase-like 2 (CDC2-related kinase), mRNA (cDNA clone IMAGE:4663827), with apparent retained intron.
AK309127 - Homo sapiens cDNA, FLJ99168.
JD536525 - Sequence 517549 from Patent EP1572962.
JD299017 - Sequence 280041 from Patent EP1572962.
JD460261 - Sequence 441285 from Patent EP1572962.
JD422627 - Sequence 403651 from Patent EP1572962.
JD075598 - Sequence 56622 from Patent EP1572962.

-  Other Names for This Gene
  Alternate Gene Symbols: CDKL2 , ENST00000307465.1, ENST00000307465.2, ENST00000307465.3, ENST00000307465.4, ENST00000307465.5, ENST00000307465.6, ENST00000307465.7, ENST00000307465.8, J3KNE8, J3KNE8_HUMAN, NM_001330724, uc011cbp.1, uc011cbp.2, uc011cbp.3, uc011cbp.4
UCSC ID: ENST00000307465.9
RefSeq Accession: NM_001330724.2
Protein: J3KNE8 CCDS: CCDS82933.1

-  Methods, Credits, and Use Restrictions
  Click here for details on how this gene model was made and data restrictions if any.