Human Gene CEBPB (ENST00000303004.5) from GENCODE V50

Description: CCAAT enhancer binding protein beta, transcript variant 2 (from RefSeq NM_005194.4)
Gencode Transcript: ENST00000303004.5
Gencode Gene: ENSG00000172216.7
Transcript (Including UTRs)
Position: hg38 chr20:50,190,830-50,192,668 Size: 1,839 Total Exon Count: 1 Strand: +
Coding Region
Position: hg38 chr20:50,191,034-50,192,071 Size: 1,038 Coding Exon Count: 1

Page Index	Sequence and Links	UniProtKB Comments	Primers	MalaCards	CTD
RNA-Seq Expression	RNA Structure	Protein Structure	Other Species	GO Annotations	mRNA Descriptions
Pathways	Other Names	Methods

Data last updated at UCSC: 2026-07-12 09:30:09

Sequence and Links to Tools and Databases

Genomic Sequence (chr20:50,190,830-50,192,668)			mRNA (may differ from genome)		Protein (345 aa)
Gene Sorter	Genome Browser	Other Species FASTA	Gene interactions	Table Schema	AlphaFold
BioGPS	Ensembl	Entrez Gene	ExonPrimer	Gencode	GeneCards
HGNC	Lynx	Malacards	MGI	OMIM	PubMed
Reactome	UniProtKB	Wikipedia	BioGrid CRISPR DB

Comments and Description Text from UniProtKB


	ID: CEBPB_HUMAN DESCRIPTION: RecName: Full=CCAAT/enhancer-binding protein beta; Short=C/EBP beta; AltName: Full=Liver activator protein; AltName: Full=Nuclear factor NF-IL6; AltName: Full=Transcription factor 5; Short=TCF-5; FUNCTION: Important transcriptional activator in the regulation of genes involved in immune and inflammatory responses. Specifically binds to an IL-1 response element in the IL-6 gene. NF-IL6 also binds to regulatory regions of several acute-phase and cytokines genes. It probably plays a role in the regulation of acute-phase reaction, inflammation and hemopoiesis. The consensus recognition site is 5'-T[TG]NNGNAA[TG]-3'. Functions in brown adipose tissue (BAT) differentiation (By similarity). Regulates the transcriptional induction of peroxisome proliferator-activated receptor gamma (PPARG). SUBUNIT: Binds DNA as a dimer and can form stable heterodimers with C/EBP alpha, delta and gamma. Interacts with TRIM28 and PTGES2. Interacts with PRDM16. Interacts with CCDC85B. Forms a complex with THOC5 (By similarity). Interacts with ZNF638; this interaction increases transcriptional activation (By similarity). Interacts with CIDEA and CIDEC; these interactions increase transcriptional activation of a subset of CEBPB downstream target genes (By similarity). Interacts with DDIT3/CHOP. INTERACTION: P04637:TP53; NbExp=4; IntAct=EBI-969696, EBI-366083; SUBCELLULAR LOCATION: Nucleus. TISSUE SPECIFICITY: Expressed at low levels in the lung, kidney and spleen. INDUCTION: By ER stress. DOMAIN: the 9aaTAD motif is a transactivation domain present in a large number of yeast and animal transcription factors. PTM: Sumoylated by polymeric chains of SUMO2 or SUMO3. PTM: Phosphorylated at Thr-235 by RPS6KA1. SIMILARITY: Belongs to the bZIP family. C/EBP subfamily. SIMILARITY: Contains 1 bZIP (basic-leucine zipper) domain. WEB RESOURCE: Name=SeattleSNPs; URL="http://pga.gs.washington.edu/data/cebpb/";

Primer design for this transcript

Primer3Plus can design qPCR Primers that straddle exon-exon-junctions, which amplify only cDNA, not genomic DNA.
Click here to load the transcript sequence and exon structure into Primer3Plus

Exonprimer can design one pair of Sanger sequencing primers around every exon, located in non-genic sequence.
Click here to open Exonprimer with this transcript

To design primers for a non-coding sequence, zoom to a region of interest and select from the drop-down menu: View > In External Tools > Primer3

MalaCards Disease Associations


	MalaCards Gene Search: CEBPB Diseases sorted by gene-association score: short-rib thoracic dysplasia 1 with or without polydactyly (2), short-rib thoracic dysplasia 2 with or without polydactyly (2), leukemia, acute promyelocytic, somatic (1), metaphyseal chondrodysplasia, schmid type (1), histidinemia (1), histidine metabolism disease (1)

Comparative Toxicogenomics Database (CTD)


	The following chemicals interact with this gene D013749 Tetrachlorodibenzodioxin D008070 Lipopolysaccharides C093973 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one D014212 Tretinoin C057693 troglitazone D000079 Acetaldehyde D002117 Calcitriol D002211 Capsaicin D002945 Cisplatin D003300 Copper more ... click here to view the complete list

RNA-Seq Expression Data from GTEx (53 Tissues, 570 Donors)


	Highest median expression: 183.67 RPKM in Whole Blood Total median expression: 2378.67 RPKM View in GTEx track of Genome Browser View at GTEx portal View GTEx Body Map

mRNA Secondary Structure of 3' and 5' UTRs

Region	Fold Energy	Bases	Energy/Base	Display As
5' UTR	-91.00	204	-0.446	Picture	PostScript	Text
3' UTR	-181.20	597	-0.304	Picture	PostScript	Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

Protein Domain and Structure Information

InterPro Domains: Graphical view of domain structure
IPR004827 - bZIP
IPR016468 - CCAAT/enhancer-binding

Pfam Domains:
PF07716 - Basic region leucine zipper

Protein Data Bank (PDB) 3-D Structure
MuPIT help

1GTW - X-ray MuPIT

1GU4 - X-ray MuPIT

1GU5 - X-ray MuPIT

1H88 - X-ray MuPIT

1H89 - X-ray MuPIT

1H8A - X-ray MuPIT

1HJB - X-ray MuPIT

1IO4 - X-ray MuPIT

2E42 - X-ray MuPIT

2E43 - X-ray MuPIT

ModBase Predicted Comparative 3D Structure on P17676


Front	Top	Side

The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.

Orthologous Genes in Other Species

Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.

Mouse	Rat	Zebrafish	D. melanogaster	C. elegans	S. cerevisiae
Genome Browser	Genome Browser	Genome Browser	No ortholog	No ortholog	No ortholog
Gene Details
Gene Sorter
MGI	RGD	Ensembl
Protein Sequence	Protein Sequence	Protein Sequence
Alignment	Alignment	Alignment

Gene Ontology (GO) Annotations with Structured Vocabulary


	Molecular Function: GO:0000977 RNA polymerase II regulatory region sequence-specific DNA binding GO:0000978 RNA polymerase II core promoter proximal region sequence-specific DNA binding GO:0000979 RNA polymerase II core promoter sequence-specific DNA binding GO:0000981 RNA polymerase II transcription factor activity, sequence-specific DNA binding GO:0001077 transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding GO:0001078 transcriptional repressor activity, RNA polymerase II core promoter proximal region sequence-specific binding GO:0003677 DNA binding GO:0003682 chromatin binding GO:0003700 transcription factor activity, sequence-specific DNA binding GO:0003705 transcription factor activity, RNA polymerase II distal enhancer sequence-specific binding GO:0005515 protein binding GO:0008134 transcription factor binding GO:0019900 kinase binding GO:0035035 histone acetyltransferase binding GO:0035259 glucocorticoid receptor binding GO:0042803 protein homodimerization activity GO:0042826 histone deacetylase binding GO:0043565 sequence-specific DNA binding GO:0044212 transcription regulatory region DNA binding GO:0044389 ubiquitin-like protein ligase binding GO:0046982 protein heterodimerization activity Biological Process: GO:0000122 negative regulation of transcription from RNA polymerase II promoter GO:0001541 ovarian follicle development GO:0001889 liver development GO:0001892 embryonic placenta development GO:0002432 granuloma formation GO:0006351 transcription, DNA-templated GO:0006355 regulation of transcription, DNA-templated GO:0006366 transcription from RNA polymerase II promoter GO:0006953 acute-phase response GO:0006954 inflammatory response GO:0006955 immune response GO:0007613 memory GO:0030154 cell differentiation GO:0030182 neuron differentiation GO:0032496 response to lipopolysaccharide GO:0032753 positive regulation of interleukin-4 production GO:0033598 mammary gland epithelial cell proliferation GO:0034976 response to endoplasmic reticulum stress GO:0035711 T-helper 1 cell activation GO:0042130 negative regulation of T cell proliferation GO:0042742 defense response to bacterium GO:0043524 negative regulation of neuron apoptotic process GO:0045408 regulation of interleukin-6 biosynthetic process GO:0045444 fat cell differentiation GO:0045600 positive regulation of fat cell differentiation GO:0045669 positive regulation of osteoblast differentiation GO:0045670 regulation of osteoclast differentiation GO:0045892 negative regulation of transcription, DNA-templated GO:0045893 positive regulation of transcription, DNA-templated GO:0045944 positive regulation of transcription from RNA polymerase II promoter GO:0050873 brown fat cell differentiation GO:0060644 mammary gland epithelial cell differentiation GO:0060850 regulation of transcription involved in cell fate commitment GO:0070059 intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress GO:0071222 cellular response to lipopolysaccharide GO:0071230 cellular response to amino acid stimulus GO:0071347 cellular response to interleukin-1 GO:0071407 cellular response to organic cyclic compound GO:0072574 hepatocyte proliferation GO:0097421 liver regeneration GO:1901329 regulation of odontoblast differentiation GO:1990440 positive regulation of transcription from RNA polymerase II promoter in response to endoplasmic reticulum stress Cellular Component: GO:0000779 condensed chromosome, centromeric region GO:0000790 nuclear chromatin GO:0005634 nucleus GO:0005654 nucleoplasm GO:0005737 cytoplasm GO:0016363 nuclear matrix GO:0036488 CHOP-C/EBP complex

Descriptions from all associated GenBank mRNAs


	E03148 - cDNA encoding nuclear factor inducing expression of interleukin-6 gene, C/EBP2. AK291536 - Homo sapiens cDNA FLJ75704 complete cds, highly similar to Homo sapiens CCAAT/enhancer binding protein (C/EBP), beta (CEBPB), mRNA. BC021931 - Homo sapiens CCAAT/enhancer binding protein (C/EBP), beta, mRNA (cDNA clone MGC:32080 IMAGE:4870789), complete cds. AF289608 - Homo sapiens clone pp9092 unknown mRNA. BC007538 - Homo sapiens CCAAT/enhancer binding protein (C/EBP), beta, mRNA (cDNA clone MGC:15409 IMAGE:3028673), complete cds. JD191095 - Sequence 172119 from Patent EP1572962. JD370507 - Sequence 351531 from Patent EP1572962. JD196637 - Sequence 177661 from Patent EP1572962. AB464474 - Synthetic construct DNA, clone: pF1KB9585, Homo sapiens CEBPB gene for CCAAT/enhancer binding protein (C/EBP), beta, without stop codon, in Flexi system. EU832661 - Synthetic construct Homo sapiens clone HAIB:100067690; DKFZo008G0231 CCAAT/enhancer binding protein (C/EBP), beta protein (CEBPB) gene, encodes complete protein. EU832739 - Synthetic construct Homo sapiens clone HAIB:100067768; DKFZo004G0232 CCAAT/enhancer binding protein (C/EBP), beta protein (CEBPB) gene, encodes complete protein. KJ161450 - Homo sapiens isolate CEBP_N1 transcription factor C/EBP beta (CEBPB) mRNA, partial cds. KJ161451 - Homo sapiens isolate CEBP_PN2 transcription factor C/EBP beta (CEBPB) mRNA, partial cds. KJ161452 - Homo sapiens isolate CEBP_N5 transcription factor C/EBP beta (CEBPB) mRNA, partial cds. KJ161453 - Homo sapiens isolate CEBP_P9 transcription factor C/EBP beta (CEBPB) mRNA, partial cds. KJ161454 - Homo sapiens isolate CEBP_PN8 transcription factor C/EBP beta (CEBPB) mRNA, partial cds. KJ161455 - Homo sapiens isolate CEBP_PN3 transcription factor C/EBP beta (CEBPB) mRNA, partial cds. KJ161456 - Homo sapiens isolate CEBP_P10 transcription factor C/EBP beta (CEBPB) mRNA, partial cds. KJ161457 - Homo sapiens isolate CEBP_P2 transcription factor C/EBP beta (CEBPB) mRNA, partial cds. KJ161458 - Homo sapiens isolate CEBP_P6 transcription factor C/EBP beta (CEBPB) mRNA, partial cds. KJ161459 - Homo sapiens isolate CEBP_N7 transcription factor C/EBP beta (CEBPB) mRNA, partial cds. KJ161460 - Homo sapiens isolate CEBP_P8 transcription factor C/EBP beta (CEBPB) mRNA, partial cds. KJ161461 - Homo sapiens isolate CEBP_P4 transcription factor C/EBP beta (CEBPB) mRNA, partial cds. KJ161462 - Homo sapiens isolate CEBP_PN7 transcription factor C/EBP beta (CEBPB) mRNA, partial cds. KJ161463 - Homo sapiens isolate CEBP_PN4 transcription factor C/EBP beta (CEBPB) mRNA, partial cds. KJ161464 - Homo sapiens isolate CEBP_P12 transcription factor C/EBP beta (CEBPB) mRNA, partial cds. KJ161465 - Homo sapiens isolate CEBP_P11 transcription factor C/EBP beta (CEBPB) mRNA, partial cds. KJ161466 - Homo sapiens isolate CEBP_N8 transcription factor C/EBP beta (CEBPB) mRNA, partial cds. KJ161467 - Homo sapiens isolate CEBP_N9 transcription factor C/EBP beta (CEBPB) mRNA, partial cds. KJ161468 - Homo sapiens isolate CEBP_P13 transcription factor C/EBP beta (CEBPB) mRNA, partial cds. KJ161469 - Homo sapiens isolate CEBP_P5 transcription factor C/EBP beta (CEBPB) mRNA, partial cds. KJ161470 - Homo sapiens isolate CEBP_PN6 transcription factor C/EBP beta (CEBPB) mRNA, partial cds. KJ161471 - Homo sapiens isolate CEBP_N3 transcription factor C/EBP beta (CEBPB) mRNA, partial cds. KJ161472 - Homo sapiens isolate CEBP_P1 transcription factor C/EBP beta (CEBPB) mRNA, partial cds. KJ161473 - Homo sapiens isolate CEBP_P3 transcription factor C/EBP beta (CEBPB) mRNA, partial cds. KJ161474 - Homo sapiens isolate CEBP_P7 transcription factor C/EBP beta (CEBPB) mRNA, partial cds. KJ161475 - Homo sapiens isolate CEBP_N4 transcription factor C/EBP beta (CEBPB) mRNA, partial cds. KJ161476 - Homo sapiens isolate CEBP_P14 transcription factor C/EBP beta (CEBPB) mRNA, partial cds. KJ161477 - Homo sapiens isolate CEBP_PN1 transcription factor C/EBP beta (CEBPB) mRNA, partial cds. KJ161478 - Homo sapiens isolate CEBP_N6 transcription factor C/EBP beta (CEBPB) mRNA, partial cds. KJ161479 - Homo sapiens isolate CEBP_N2 transcription factor C/EBP beta (CEBPB) mRNA, partial cds. KJ161480 - Homo sapiens isolate CEBP_PN9 transcription factor C/EBP beta (CEBPB) mRNA, partial cds. KJ161481 - Homo sapiens isolate CEBP_PN5 transcription factor C/EBP beta (CEBPB) mRNA, partial cds. BC005132 - Homo sapiens CCAAT/enhancer binding protein (C/EBP), beta, mRNA (cDNA clone IMAGE:3836438), partial cds. D63161 - Homo sapiens mRNA for DNA binding protein NF-IL6, partial cds. JD196299 - Sequence 177323 from Patent EP1572962. M98056 - Human anti-oncogene mRNA. JD419691 - Sequence 400715 from Patent EP1572962. JD420512 - Sequence 401536 from Patent EP1572962. JD147368 - Sequence 128392 from Patent EP1572962. HI958674 - Sequence 17 from Patent WO2010135714. HI958679 - Sequence 22 from Patent WO2010135714. LP925062 - Sequence 20 from Patent WO2017182580. LP925061 - Sequence 19 from Patent WO2017182580.

Biochemical and Signaling Pathways


	BioCarta from NCI Cancer Genome Anatomy Project h_il6Pathway - IL 6 signaling pathway Reactome (by CSHL, EBI, and GO) Protein P17676 (Reactome details) participates in the following event(s): R-HSA-3857329 MAPK3 (ERK1) and MAPK1 (ERK2) phosphorylate CEBPB R-HSA-3857336 CEBPB homodimerization R-HSA-3857328 RPS6KA1/2/3 phosphorylates CEBPB on S321 R-HSA-3857305 Activated CEBPB and NFKB complex bind IL6 promoter R-HSA-3857308 Activated CEBPB and NFKB complex bind IL8 promoter R-HSA-3857345 Activated CEBPB binds CDKN2B promoter R-HSA-2559582 Senescence-Associated Secretory Phenotype (SASP) R-HSA-381340 Transcriptional regulation of white adipocyte differentiation R-HSA-2559583 Cellular Senescence R-HSA-1266738 Developmental Biology R-HSA-2262752 Cellular responses to stress R-HSA-8953897 Cellular responses to external stimuli

Other Names for This Gene


	Alternate Gene Symbols: A8K671, CEBPB , CEBPB_HUMAN, ENST00000303004.1, ENST00000303004.2, ENST00000303004.3, ENST00000303004.4, NM_005194, P17676, PP9092, Q96IH2, Q9H4Z5, TCF5, uc002xvi.1, uc002xvi.2, uc002xvi.3, uc002xvi.4, uc002xvi.5 UCSC ID: ENST00000303004.5 RefSeq Accession: NM_005194.4 Protein: P17676 (aka CEBPB_HUMAN) CCDS: CCDS13429.1

Methods, Credits, and Use Restrictions


	Click here for details on how this gene model was made and data restrictions if any.