ID:CLD18_HUMAN DESCRIPTION: RecName: Full=Claudin-18; FUNCTION: Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium- independent cell-adhesion activity (By similarity). SUBCELLULAR LOCATION: Cell junction, tight junction. Cell membrane; Multi-pass membrane protein. TISSUE SPECIFICITY: Concentrated at the cell-cell borders of epithelial cells. SIMILARITY: Belongs to the claudin family.
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
Pfam Domains: PF00822 - PMP-22/EMP/MP20/Claudin family
ModBase Predicted Comparative 3D Structure on P56856
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
Gene Ontology (GO) Annotations with Structured Vocabulary
Molecular Function: GO:0005198 structural molecule activity GO:0042802 identical protein binding
Biological Process: GO:0016338 calcium-independent cell-cell adhesion via plasma membrane cell-adhesion molecules GO:0045471 response to ethanol GO:0045779 negative regulation of bone resorption GO:0048565 digestive tract development GO:0071847 TNFSF11-mediated signaling pathway GO:1900181 negative regulation of protein localization to nucleus GO:2001205 negative regulation of osteoclast development
Sequence and Links to Tools and Databases 
Microarray Expression Data 
