Description: Homo sapiens coenzyme Q2, polyprenyltransferase (COQ2), transcript variant 2, mRNA; nuclear gene for mitochondrial product. (from RefSeq NM_001358921) RefSeq Summary (NM_001358921): This gene encodes an enzyme that functions in the final steps in the biosynthesis of CoQ (ubiquinone), a redox carrier in the mitochondrial respiratory chain and a lipid-soluble antioxidant. This enzyme, which is part of the coenzyme Q10 pathway, catalyzes the prenylation of parahydroxybenzoate with an all-trans polyprenyl group. Mutations in this gene cause coenzyme Q10 deficiency, a mitochondrial encephalomyopathy, and also COQ2 nephropathy, an inherited form of mitochondriopathy with primary renal involvement. [provided by RefSeq, Oct 2009]. Gencode Transcript: ENST00000647002.2 Gencode Gene: ENSG00000173085.15 Transcript (Including UTRs) Position: hg38 chr4:83,263,824-83,284,798 Size: 20,975 Total Exon Count: 7 Strand: - Coding Region Position: hg38 chr4:83,264,199-83,284,764 Size: 20,566 Coding Exon Count: 7
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.