ID:COQ7_HUMAN DESCRIPTION: RecName: Full=Ubiquinone biosynthesis protein COQ7 homolog; AltName: Full=Coenzyme Q biosynthesis protein 7 homolog; AltName: Full=Timing protein clk-1 homolog; Flags: Precursor; FUNCTION: Involved in lifespan determination in ubiquinone- independent manner. Involved in ubiquinone biosynthesis. Potential central metabolic regulator (By similarity). COFACTOR: Binds 2 iron ions per subunit (By similarity). PATHWAY: Cofactor biosynthesis; ubiquinone biosynthesis. SUBCELLULAR LOCATION: Mitochondrion inner membrane; Peripheral membrane protein; Matrix side. Note=Synthesized as a preprotein that is imported into the mitochondrial matrix, where the sequence is cleaved off and the mature protein becomes loosely associated with the inner membrane (By similarity). TISSUE SPECIFICITY: Expressed dominantly in heart and skeletal muscle. SIMILARITY: Belongs to the COQ7 family.
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
Pfam Domains: PF03232 - Ubiquinone biosynthesis protein COQ7
ModBase Predicted Comparative 3D Structure on Q99807
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
Biological Process: GO:0000122 negative regulation of transcription from RNA polymerase II promoter GO:0006744 ubiquinone biosynthetic process GO:0045944 positive regulation of transcription from RNA polymerase II promoter GO:0055114 oxidation-reduction process GO:2000377 regulation of reactive oxygen species metabolic process
Sequence and Links to Tools and Databases 
Microarray Expression Data 
