Human Gene CPLX2 (ENST00000359546.8) Description and Page Index
Description: Homo sapiens complexin 2 (CPLX2), transcript variant 1, mRNA. (from RefSeq NM_006650) RefSeq Summary (NM_006650): Proteins encoded by the complexin/synaphin gene family are cytosolic proteins that function in synaptic vesicle exocytosis. These proteins bind syntaxin, part of the SNAP receptor. The protein product of this gene binds to the SNAP receptor complex and disrupts it, allowing transmitter release. Two transcript variants encoding the same protein have been found for this gene. [provided by RefSeq, Jul 2008]. Gencode Transcript: ENST00000359546.8 Gencode Gene: ENSG00000145920.15 Transcript (Including UTRs) Position: hg38 chr5:175,796,310-175,884,020 Size: 87,711 Total Exon Count: 5 Strand: + Coding Region Position: hg38 chr5:175,878,740-175,880,045 Size: 1,306 Coding Exon Count: 3
ID:CPLX2_HUMAN DESCRIPTION: RecName: Full=Complexin-2; AltName: Full=Complexin II; Short=CPX II; AltName: Full=Synaphin-1; FUNCTION: Negatively regulates the formation of synaptic vesicle clustering at active zone to the presynaptic membrane in postmitotic neurons. Positively regulates a late step in synaptic vesicle exocytosis. Also involved in mast cell exocytosis (By similarity). SUBUNIT: Binds to the SNARE core complex containing SNAP25, VAMP2 and STX1A (By similarity). SUBCELLULAR LOCATION: Cytoplasm, cytosol. Note=Enriched at synaptic-releasing sites in mature neurons (By similarity). TISSUE SPECIFICITY: Nervous system. In hippocampus and cerebellum, expressed mainly by excitatory neurons. Down-regulated in brain cortex from patients suffering from Huntington disease, bipolar disorder or major depression. Down-regulated in cerebellum from patients with schizophrenia. SIMILARITY: Belongs to the complexin/synaphin family.
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
ModBase Predicted Comparative 3D Structure on Q6PUV4
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.