Human Gene CPLX2 (ENST00000359546.8) Description and Page Index
  Description: Homo sapiens complexin 2 (CPLX2), transcript variant 1, mRNA. (from RefSeq NM_006650)
RefSeq Summary (NM_006650): Proteins encoded by the complexin/synaphin gene family are cytosolic proteins that function in synaptic vesicle exocytosis. These proteins bind syntaxin, part of the SNAP receptor. The protein product of this gene binds to the SNAP receptor complex and disrupts it, allowing transmitter release. Two transcript variants encoding the same protein have been found for this gene. [provided by RefSeq, Jul 2008].
Gencode Transcript: ENST00000359546.8
Gencode Gene: ENSG00000145920.15
Transcript (Including UTRs)
   Position: hg38 chr5:175,796,310-175,884,020 Size: 87,711 Total Exon Count: 5 Strand: +
Coding Region
   Position: hg38 chr5:175,878,740-175,880,045 Size: 1,306 Coding Exon Count: 3 

Page IndexSequence and LinksUniProtKB CommentsMalaCardsCTDRNA-Seq Expression
Microarray ExpressionRNA StructureProtein StructureOther SpeciesGO AnnotationsmRNA Descriptions
Other NamesMethods
Data last updated: 2019-09-04

-  Sequence and Links to Tools and Databases
 
Genomic Sequence (chr5:175,796,310-175,884,020)mRNA (may differ from genome)Protein (134 aa)
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Stanford SOURCEUniProtKBWikipedia

-  Comments and Description Text from UniProtKB
  ID: CPLX2_HUMAN
DESCRIPTION: RecName: Full=Complexin-2; AltName: Full=Complexin II; Short=CPX II; AltName: Full=Synaphin-1;
FUNCTION: Negatively regulates the formation of synaptic vesicle clustering at active zone to the presynaptic membrane in postmitotic neurons. Positively regulates a late step in synaptic vesicle exocytosis. Also involved in mast cell exocytosis (By similarity).
SUBUNIT: Binds to the SNARE core complex containing SNAP25, VAMP2 and STX1A (By similarity).
SUBCELLULAR LOCATION: Cytoplasm, cytosol. Note=Enriched at synaptic-releasing sites in mature neurons (By similarity).
TISSUE SPECIFICITY: Nervous system. In hippocampus and cerebellum, expressed mainly by excitatory neurons. Down-regulated in brain cortex from patients suffering from Huntington disease, bipolar disorder or major depression. Down-regulated in cerebellum from patients with schizophrenia.
SIMILARITY: Belongs to the complexin/synaphin family.

-  MalaCards Disease Associations
  MalaCards Gene Search: CPLX2
Diseases sorted by gene-association score: schizophrenia (4), huntington disease (4)

-  Comparative Toxicogenomics Database (CTD)
  The following chemicals interact with this gene           more ... click here to view the complete list

-  RNA-Seq Expression Data from GTEx (53 Tissues, 570 Donors)
  Highest median expression: 262.65 RPKM in Brain - Cerebellar Hemisphere
Total median expression: 1607.03 RPKM



View in GTEx track of Genome Browser    View at GTEx portal     View GTEx Body Map

+  Microarray Expression Data
  Press "+" in the title bar above to open this section.

-  mRNA Secondary Structure of 3' and 5' UTRs
 
RegionFold EnergyBasesEnergy/Base
Display As
5' UTR -274.30643-0.427 Picture PostScript Text
3' UTR -1599.603975-0.402 Picture PostScript Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

-  Protein Domain and Structure Information
  InterPro Domains: Graphical view of domain structure
IPR008849 - Synaphin

Pfam Domains:
PF05835 - Synaphin protein

ModBase Predicted Comparative 3D Structure on Q6PUV4
FrontTopSide
The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.

-  Orthologous Genes in Other Species
  Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
MouseRatZebrafishD. melanogasterC. elegansS. cerevisiae
Genome BrowserGenome BrowserNo orthologNo orthologNo orthologNo ortholog
Gene Details     
Gene Sorter     
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Protein SequenceProtein Sequence    
AlignmentAlignment    

-  Gene Ontology (GO) Annotations with Structured Vocabulary
  Molecular Function:
GO:0000149 SNARE binding
GO:0017075 syntaxin-1 binding
GO:0019905 syntaxin binding
GO:0048306 calcium-dependent protein binding

Biological Process:
GO:0006836 neurotransmitter transport
GO:0006887 exocytosis
GO:0006904 vesicle docking involved in exocytosis
GO:0007399 nervous system development
GO:0016079 synaptic vesicle exocytosis
GO:0017157 regulation of exocytosis
GO:0030154 cell differentiation
GO:0031915 positive regulation of synaptic plasticity
GO:0043303 mast cell degranulation

Cellular Component:
GO:0005737 cytoplasm
GO:0005829 cytosol
GO:0030425 dendrite
GO:0031201 SNARE complex
GO:0042629 mast cell granule
GO:0043025 neuronal cell body
GO:0045202 synapse
GO:0070033 synaptobrevin 2-SNAP-25-syntaxin-1a-complexin II complex
GO:0070554 synaptobrevin 2-SNAP-25-syntaxin-3-complexin complex
GO:0098793 presynapse


-  Descriptions from all associated GenBank mRNAs
  U35100 - Human complexin II mRNA, complete cds.
JD270088 - Sequence 251112 from Patent EP1572962.
AY576870 - Homo sapiens complexin 2 (CPLX2) mRNA, partial cds.
AK124837 - Homo sapiens cDNA FLJ42847 fis, clone BRHIP2004312.
AK314177 - Homo sapiens cDNA, FLJ94897, Homo sapiens complexin 2 (CPLX2), mRNA.
AK293819 - Homo sapiens cDNA FLJ52864 complete cds, moderately similar to Complexin-2.
JD046154 - Sequence 27178 from Patent EP1572962.
JD295667 - Sequence 276691 from Patent EP1572962.
JD363720 - Sequence 344744 from Patent EP1572962.
BC093706 - Homo sapiens complexin 2, mRNA (cDNA clone MGC:120741 IMAGE:7939551), complete cds.
BC112287 - Homo sapiens complexin 2, transcript variant 2, mRNA (cDNA clone MGC:138492 IMAGE:8327755), complete cds.
AB529062 - Synthetic construct DNA, clone: pF1KB3848, Homo sapiens CPLX2 gene for complexin 2, without stop codon, in Flexi system.
HQ258072 - Synthetic construct Homo sapiens clone IMAGE:100072381 Unknown protein gene, encodes complete protein.
KJ893141 - Synthetic construct Homo sapiens clone ccsbBroadEn_02535 CPLX2 gene, encodes complete protein.
JD239576 - Sequence 220600 from Patent EP1572962.
JD104968 - Sequence 85992 from Patent EP1572962.
JD419346 - Sequence 400370 from Patent EP1572962.
JD077445 - Sequence 58469 from Patent EP1572962.
JD485225 - Sequence 466249 from Patent EP1572962.
JD213750 - Sequence 194774 from Patent EP1572962.
JD414600 - Sequence 395624 from Patent EP1572962.
JD418458 - Sequence 399482 from Patent EP1572962.
JD525549 - Sequence 506573 from Patent EP1572962.
AK055043 - Homo sapiens cDNA FLJ30481 fis, clone BRAWH1000180.
JD282763 - Sequence 263787 from Patent EP1572962.
AK094266 - Homo sapiens cDNA FLJ36947 fis, clone BRACE2005681.
JD204753 - Sequence 185777 from Patent EP1572962.
JD218078 - Sequence 199102 from Patent EP1572962.
JD151035 - Sequence 132059 from Patent EP1572962.
JD171553 - Sequence 152577 from Patent EP1572962.
JD122417 - Sequence 103441 from Patent EP1572962.
JD564994 - Sequence 546018 from Patent EP1572962.
AL512758 - Homo sapiens mRNA; cDNA DKFZp547D155 (from clone DKFZp547D155).
AK126590 - Homo sapiens cDNA FLJ44627 fis, clone BRACE2017844.
JD399160 - Sequence 380184 from Patent EP1572962.
BC052974 - Homo sapiens cDNA clone IMAGE:3879495, partial cds.
JD182175 - Sequence 163199 from Patent EP1572962.
JD121827 - Sequence 102851 from Patent EP1572962.
JD449437 - Sequence 430461 from Patent EP1572962.
JD193883 - Sequence 174907 from Patent EP1572962.
JD487439 - Sequence 468463 from Patent EP1572962.
JD547094 - Sequence 528118 from Patent EP1572962.
JD103256 - Sequence 84280 from Patent EP1572962.
JD241135 - Sequence 222159 from Patent EP1572962.
JD283930 - Sequence 264954 from Patent EP1572962.
JD341192 - Sequence 322216 from Patent EP1572962.
JD206915 - Sequence 187939 from Patent EP1572962.
JD351659 - Sequence 332683 from Patent EP1572962.
JD523293 - Sequence 504317 from Patent EP1572962.
JD401780 - Sequence 382804 from Patent EP1572962.
JD077150 - Sequence 58174 from Patent EP1572962.
BC065485 - Homo sapiens cDNA clone IMAGE:4892076, partial cds.
Y15167 - Homo sapiens mRNA for Hfb1 protein, 3'UTR.
JD357621 - Sequence 338645 from Patent EP1572962.
JD384590 - Sequence 365614 from Patent EP1572962.
JD266392 - Sequence 247416 from Patent EP1572962.
JD162612 - Sequence 143636 from Patent EP1572962.
JD282663 - Sequence 263687 from Patent EP1572962.
JD135065 - Sequence 116089 from Patent EP1572962.
JD467259 - Sequence 448283 from Patent EP1572962.
JD181916 - Sequence 162940 from Patent EP1572962.
JD279137 - Sequence 260161 from Patent EP1572962.
JD115037 - Sequence 96061 from Patent EP1572962.
JD106250 - Sequence 87274 from Patent EP1572962.
JD219279 - Sequence 200303 from Patent EP1572962.
JD453527 - Sequence 434551 from Patent EP1572962.
JD099797 - Sequence 80821 from Patent EP1572962.
JD111696 - Sequence 92720 from Patent EP1572962.
BC039560 - Homo sapiens complexin 2, mRNA (cDNA clone IMAGE:4941758).
JD489454 - Sequence 470478 from Patent EP1572962.
JD466555 - Sequence 447579 from Patent EP1572962.
JD363993 - Sequence 345017 from Patent EP1572962.
JD231263 - Sequence 212287 from Patent EP1572962.
JD426638 - Sequence 407662 from Patent EP1572962.
JD126032 - Sequence 107056 from Patent EP1572962.
JD396283 - Sequence 377307 from Patent EP1572962.
JD391426 - Sequence 372450 from Patent EP1572962.
JD111830 - Sequence 92854 from Patent EP1572962.

-  Other Names for This Gene
  Alternate Gene Symbols: B2RAG2, CPLX2_HUMAN, NM_006650, O09056, Q13329, Q28184, Q52M15, Q64386, Q6PUV4, uc003mde.1, uc003mde.2
UCSC ID: uc003mde.2
RefSeq Accession: NM_006650
Protein: Q6PUV4 (aka CPLX2_HUMAN or CLX2_HUMAN)
CCDS: CCDS4396.1

-  Methods, Credits, and Use Restrictions
  Click here for details on how this gene model was made and data restrictions if any.