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Human Gene DIPK2B (ENST00000377934.5) from GENCODE V50
  Description: divergent protein kinase domain 2B, transcript variant 2 (from RefSeq NM_024689.3)
Gencode Transcript: ENST00000377934.5
Gencode Gene: ENSG00000147113.19
Transcript (Including UTRs)
   Position: hg38 chrX:45,162,310-45,200,965 Size: 38,656 Total Exon Count: 3 Strand: -
Coding Region
   Position: hg38 chrX:45,164,199-45,200,826 Size: 36,628 Coding Exon Count: 3 

Page IndexSequence and LinksUniProtKB CommentsPrimersRNA-Seq ExpressionMicroarray Expression
RNA StructureProtein StructureOther SpeciesGO AnnotationsmRNA DescriptionsOther Names
Methods
Data last updated at UCSC: 2026-07-12 09:30:09

-  Comments and Description Text from UniProtKB
  ID: DIA1R_HUMAN
DESCRIPTION: RecName: Full=Deleted in autism-related protein 1; Flags: Precursor;
SUBCELLULAR LOCATION: Secreted (Potential).
DISEASE: Note=Genetic variations in CXorf36 may be associated with susceptibility to autism.
SIMILARITY: Belongs to the DIA1 family.

-  Primer design for this transcript
 

Primer3Plus can design qPCR Primers that straddle exon-exon-junctions, which amplify only cDNA, not genomic DNA.
Click here to load the transcript sequence and exon structure into Primer3Plus

Exonprimer can design one pair of Sanger sequencing primers around every exon, located in non-genic sequence.
Click here to open Exonprimer with this transcript

To design primers for a non-coding sequence, zoom to a region of interest and select from the drop-down menu: View > In External Tools > Primer3


-  RNA-Seq Expression Data from GTEx (53 Tissues, 570 Donors)
  Highest median expression: 18.29 RPKM in Adipose - Visceral (Omentum)
Total median expression: 234.31 RPKM



View in GTEx track of Genome Browser    View at GTEx portal     View GTEx Body Map

+  Microarray Expression Data
 
Expression ratio colors:

GNF Expression Atlas 2 Data from U133A and GNF1H Chips

      
      
      
     
    
     
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-  mRNA Secondary Structure of 3' and 5' UTRs
 
RegionFold EnergyBasesEnergy/Base
Display As
5' UTR -53.40139-0.384 Picture PostScript Text
3' UTR -529.001889-0.280 Picture PostScript Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

-  Protein Domain and Structure Information
  InterPro Domains: Graphical view of domain structure
IPR020519 - UPF0672

ModBase Predicted Comparative 3D Structure on Q9H7Y0
FrontTopSide
The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.

-  Orthologous Genes in Other Species
  Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
MouseRatZebrafishD. melanogasterC. elegansS. cerevisiae
Genome BrowserNo orthologNo orthologNo orthologNo orthologNo ortholog
Gene Details     
Gene Sorter     
MGI     
Protein Sequence     
Alignment     

-  Gene Ontology (GO) Annotations with Structured Vocabulary
  Biological Process:
GO:0009966 regulation of signal transduction

Cellular Component:
GO:0005576 extracellular region


-  Descriptions from all associated GenBank mRNAs
  AK094877 - Homo sapiens cDNA FLJ37558 fis, clone BRCOC1000087.
AK294472 - Homo sapiens cDNA FLJ55198 complete cds.
BC035375 - Homo sapiens chromosome X open reading frame 36, mRNA (cDNA clone IMAGE:5178767).
AK024165 - Homo sapiens cDNA FLJ14103 fis, clone MAMMA1001073.
JD347972 - Sequence 328996 from Patent EP1572962.
BC137528 - Homo sapiens chromosome X open reading frame 36, mRNA (cDNA clone IMAGE:9021528), complete cds.
BC137529 - Homo sapiens chromosome X open reading frame 36, mRNA (cDNA clone IMAGE:9021529), complete cds.
JD450640 - Sequence 431664 from Patent EP1572962.
JD234250 - Sequence 215274 from Patent EP1572962.
JD551869 - Sequence 532893 from Patent EP1572962.
JD175273 - Sequence 156297 from Patent EP1572962.
JD057804 - Sequence 38828 from Patent EP1572962.
JD452361 - Sequence 433385 from Patent EP1572962.
JD088272 - Sequence 69296 from Patent EP1572962.
JD518700 - Sequence 499724 from Patent EP1572962.
JD498922 - Sequence 479946 from Patent EP1572962.
JD503592 - Sequence 484616 from Patent EP1572962.
JD091234 - Sequence 72258 from Patent EP1572962.
JD537558 - Sequence 518582 from Patent EP1572962.
JD557796 - Sequence 538820 from Patent EP1572962.
JD373098 - Sequence 354122 from Patent EP1572962.
JD047996 - Sequence 29020 from Patent EP1572962.
JD243531 - Sequence 224555 from Patent EP1572962.
JD114400 - Sequence 95424 from Patent EP1572962.
JD121629 - Sequence 102653 from Patent EP1572962.
JD172614 - Sequence 153638 from Patent EP1572962.
JD259485 - Sequence 240509 from Patent EP1572962.
JD464303 - Sequence 445327 from Patent EP1572962.
JD363766 - Sequence 344790 from Patent EP1572962.
AY358764 - Homo sapiens clone DNA92290 EPQL1862 (UNQ1862) mRNA, complete cds.
JD335216 - Sequence 316240 from Patent EP1572962.
JD336249 - Sequence 317273 from Patent EP1572962.

-  Other Names for This Gene
  Alternate Gene Symbols: A8MUU5, B2RPN7, CXorf36, DIA1R , DIK2B_HUMAN, DIPK2B , ENST00000377934.1, ENST00000377934.2, ENST00000377934.3, ENST00000377934.4, NM_024689, Q6UWJ5, Q9H7Y0, uc004dgi.1, uc004dgi.2, uc004dgi.3, uc004dgi.4, uc004dgi.5, uc004dgi.6, UNQ1862/PRO3743
UCSC ID: ENST00000377934.5
RefSeq Accession: NM_024689.3
Protein: Q9H7Y0 (aka DIA1R_HUMAN)

-  Methods, Credits, and Use Restrictions
  Click here for details on how this gene model was made and data restrictions if any.