Human Gene CYP27C1 (ENST00000664447.2) from GENCODE V44
  Description: Homo sapiens cytochrome P450 family 27 subfamily C member 1 (CYP27C1), transcript variant 3, mRNA. (from RefSeq NM_001367502)
RefSeq Summary (NM_001367502): This gene encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. [provided by RefSeq, Jul 2008]. Sequence Note: The RefSeq transcript and protein were derived from genomic sequence to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on alignments.
Gencode Transcript: ENST00000664447.2
Gencode Gene: ENSG00000186684.14
Transcript (Including UTRs)
   Position: hg38 chr2:127,183,832-127,220,299 Size: 36,468 Total Exon Count: 9 Strand: -
Coding Region
   Position: hg38 chr2:127,187,271-127,220,270 Size: 33,000 Coding Exon Count: 9 

Page IndexSequence and LinksPrimersCTDRNA-Seq ExpressionMicroarray Expression
RNA StructureOther SpeciesmRNA DescriptionsOther NamesMethods
Data last updated at UCSC: 2023-08-18 00:09:47

-  Sequence and Links to Tools and Databases
 
Genomic Sequence (chr2:127,183,832-127,220,299)mRNA (may differ from genome)Protein (537 aa)
Gene SorterGenome BrowserOther Species FASTAGene interactionsTable SchemaAlphaFold
BioGPSEnsemblEntrez GeneExonPrimerGencodeGeneCards
HGNCLynxMalacardsMGIPubMedUniProtKB
WikipediaBioGrid CRISPR DB

-  Primer design for this transcript
 

Primer3Plus can design qPCR Primers that straddle exon-exon-junctions, which amplify only cDNA, not genomic DNA.
Click here to load the transcript sequence and exon structure into Primer3Plus

Exonprimer can design one pair of Sanger sequencing primers around every exon, located in non-genic sequence.
Click here to open Exonprimer with this transcript

To design primers for a non-coding sequence, zoom to a region of interest and select from the drop-down menu: View > In External Tools > Primer3


-  Comparative Toxicogenomics Database (CTD)
  The following chemicals interact with this gene

-  RNA-Seq Expression Data from GTEx (53 Tissues, 570 Donors)
  Highest median expression: 3.73 RPKM in Cervix - Endocervix
Total median expression: 23.33 RPKM



View in GTEx track of Genome Browser    View at GTEx portal     View GTEx Body Map

+  Microarray Expression Data
  Press "+" in the title bar above to open this section.

-  mRNA Secondary Structure of 3' and 5' UTRs
 
RegionFold EnergyBasesEnergy/Base
Display As
5' UTR -1.8029-0.062 Picture PostScript Text
3' UTR -1004.603439-0.292 Picture PostScript Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

-  Orthologous Genes in Other Species
  Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
MouseRatZebrafishD. melanogasterC. elegansS. cerevisiae
Genome BrowserGenome BrowserGenome BrowserGenome BrowserNo orthologNo ortholog
Gene Details     
Gene Sorter     
MGIRGDEnsemblEnsembl  
Protein SequenceProtein SequenceProtein SequenceProtein Sequence  
AlignmentAlignmentAlignmentAlignment  

-  Descriptions from all associated GenBank mRNAs
  BC039307 - Homo sapiens cytochrome P450, family 27, subfamily C, polypeptide 1, mRNA (cDNA clone MGC:39642 IMAGE:5266370), complete cds.
JD053322 - Sequence 34346 from Patent EP1572962.
JD471154 - Sequence 452178 from Patent EP1572962.
JD341912 - Sequence 322936 from Patent EP1572962.
JD344205 - Sequence 325229 from Patent EP1572962.
JD344240 - Sequence 325264 from Patent EP1572962.
JD205929 - Sequence 186953 from Patent EP1572962.
JD272456 - Sequence 253480 from Patent EP1572962.
JD559401 - Sequence 540425 from Patent EP1572962.
JD198895 - Sequence 179919 from Patent EP1572962.
JD516483 - Sequence 497507 from Patent EP1572962.
JD405165 - Sequence 386189 from Patent EP1572962.
JD057116 - Sequence 38140 from Patent EP1572962.
JD100382 - Sequence 81406 from Patent EP1572962.
JD542195 - Sequence 523219 from Patent EP1572962.
JD421974 - Sequence 402998 from Patent EP1572962.
JD381020 - Sequence 362044 from Patent EP1572962.
JD462343 - Sequence 443367 from Patent EP1572962.
JD036367 - Sequence 17391 from Patent EP1572962.
JD507617 - Sequence 488641 from Patent EP1572962.
JD447968 - Sequence 428992 from Patent EP1572962.
JD267503 - Sequence 248527 from Patent EP1572962.
JD228989 - Sequence 210013 from Patent EP1572962.
JD281623 - Sequence 262647 from Patent EP1572962.
JD445124 - Sequence 426148 from Patent EP1572962.
JD429016 - Sequence 410040 from Patent EP1572962.
JD467688 - Sequence 448712 from Patent EP1572962.
JD273355 - Sequence 254379 from Patent EP1572962.
JD559578 - Sequence 540602 from Patent EP1572962.
JD092477 - Sequence 73501 from Patent EP1572962.
JD207920 - Sequence 188944 from Patent EP1572962.
JD359013 - Sequence 340037 from Patent EP1572962.
JD147399 - Sequence 128423 from Patent EP1572962.
JD036488 - Sequence 17512 from Patent EP1572962.
JD165446 - Sequence 146470 from Patent EP1572962.
JD361656 - Sequence 342680 from Patent EP1572962.
JD297069 - Sequence 278093 from Patent EP1572962.
JD512836 - Sequence 493860 from Patent EP1572962.
JD197844 - Sequence 178868 from Patent EP1572962.
JD231911 - Sequence 212935 from Patent EP1572962.
JD144635 - Sequence 125659 from Patent EP1572962.
JD301886 - Sequence 282910 from Patent EP1572962.
JD558468 - Sequence 539492 from Patent EP1572962.
JD438485 - Sequence 419509 from Patent EP1572962.
JD267948 - Sequence 248972 from Patent EP1572962.
JD155256 - Sequence 136280 from Patent EP1572962.
JD178590 - Sequence 159614 from Patent EP1572962.
JD317031 - Sequence 298055 from Patent EP1572962.
JD225929 - Sequence 206953 from Patent EP1572962.
JD480618 - Sequence 461642 from Patent EP1572962.
AK131190 - Homo sapiens cDNA FLJ16008 fis, clone NT2NE2000390, weakly similar to 25-HYDROXYVITAMIN D-1 ALPHA HYDROXYLASE, MITOCHONDRIAL PRECURSOR (EC 1.14.-.-).
JD088741 - Sequence 69765 from Patent EP1572962.
JD510947 - Sequence 491971 from Patent EP1572962.
JD219782 - Sequence 200806 from Patent EP1572962.
JD463490 - Sequence 444514 from Patent EP1572962.
JD337826 - Sequence 318850 from Patent EP1572962.
JD444192 - Sequence 425216 from Patent EP1572962.
JD532606 - Sequence 513630 from Patent EP1572962.
JD257915 - Sequence 238939 from Patent EP1572962.
JD352143 - Sequence 333167 from Patent EP1572962.
JD452792 - Sequence 433816 from Patent EP1572962.
JD533118 - Sequence 514142 from Patent EP1572962.
JD436197 - Sequence 417221 from Patent EP1572962.
JD487680 - Sequence 468704 from Patent EP1572962.
JD430880 - Sequence 411904 from Patent EP1572962.
JD258139 - Sequence 239163 from Patent EP1572962.
JD109591 - Sequence 90615 from Patent EP1572962.
JD295313 - Sequence 276337 from Patent EP1572962.
JD315831 - Sequence 296855 from Patent EP1572962.
JD293682 - Sequence 274706 from Patent EP1572962.
JD460166 - Sequence 441190 from Patent EP1572962.
JD162050 - Sequence 143074 from Patent EP1572962.
KJ900624 - Synthetic construct Homo sapiens clone ccsbBroadEn_10018 CYP27C1 gene, encodes complete protein.

-  Other Names for This Gene
  Alternate Gene Symbols: A0A7N4I3A3, ENST00000664447.1, NM_001367502, uc288alo.1
UCSC ID: ENST00000664447.2
RefSeq Accession: NM_001367502

-  Methods, Credits, and Use Restrictions
  Click here for details on how this gene model was made and data restrictions if any.