Description: Homo sapiens death associated protein (DAP), transcript variant 2, mRNA. (from RefSeq NM_004394) RefSeq Summary (NM_004394): This gene encodes a basic, proline-rich, 15-kD protein. The protein acts as a positive mediator of programmed cell death that is induced by interferon-gamma. Alternatively spliced transcript variants encoding distinct isoforms have been found for this gene. [provided by RefSeq, May 2014]. Gencode Transcript: ENST00000230895.11 Gencode Gene: ENSG00000112977.16 Transcript (Including UTRs) Position: hg38 chr5:10,679,230-10,761,234 Size: 82,005 Total Exon Count: 4 Strand: - Coding Region Position: hg38 chr5:10,681,056-10,761,068 Size: 80,013 Coding Exon Count: 4
ID:DAP1_HUMAN DESCRIPTION: RecName: Full=Death-associated protein 1; Short=DAP-1; FUNCTION: Negative regulator of autophagy. Involved in mediating interferon-gamma-induced cell death. PTM: Phosphorylated. Phosphorylation by MTOR inhibits the suppressive activity of DAP toward autophagy. WEB RESOURCE: Name=NIEHS-SNPs; URL="http://egp.gs.washington.edu/data/dap/";
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
ModBase Predicted Comparative 3D Structure on P51397
The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.
Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.