Human Gene DAP (ENST00000230895.11)
  Description: Homo sapiens death associated protein (DAP), transcript variant 2, mRNA. (from RefSeq NM_004394)
RefSeq Summary (NM_004394): This gene encodes a basic, proline-rich, 15-kD protein. The protein acts as a positive mediator of programmed cell death that is induced by interferon-gamma. Alternatively spliced transcript variants encoding distinct isoforms have been found for this gene. [provided by RefSeq, May 2014].
Gencode Transcript: ENST00000230895.11
Gencode Gene: ENSG00000112977.16
Transcript (Including UTRs)
   Position: hg38 chr5:10,679,230-10,761,234 Size: 82,005 Total Exon Count: 4 Strand: -
Coding Region
   Position: hg38 chr5:10,681,056-10,761,068 Size: 80,013 Coding Exon Count: 4 

Page IndexSequence and LinksUniProtKB CommentsMalaCardsCTDRNA-Seq Expression
Microarray ExpressionRNA StructureProtein StructureOther SpeciesGO AnnotationsmRNA Descriptions
Other NamesMethods
Data last updated at UCSC: 2021-01-14 15:32:12

-  Sequence and Links to Tools and Databases
 
Genomic Sequence (chr5:10,679,230-10,761,234)mRNA (may differ from genome)Protein (102 aa)
Gene SorterGenome BrowserOther Species FASTAGene interactionsTable SchemaBioGPS
CGAPEnsemblEntrez GeneExonPrimerGeneCardsHGNC
HPRDLynxMGIneXtProtOMIMPubMed
UniProtKBWikipedia

-  Comments and Description Text from UniProtKB
  ID: DAP1_HUMAN
DESCRIPTION: RecName: Full=Death-associated protein 1; Short=DAP-1;
FUNCTION: Negative regulator of autophagy. Involved in mediating interferon-gamma-induced cell death.
PTM: Phosphorylated. Phosphorylation by MTOR inhibits the suppressive activity of DAP toward autophagy.
WEB RESOURCE: Name=NIEHS-SNPs; URL="http://egp.gs.washington.edu/data/dap/";

-  MalaCards Disease Associations
  MalaCards Gene Search: DAP
Diseases sorted by gene-association score: pediatric lymphoma (1)

-  Comparative Toxicogenomics Database (CTD)
  The following chemicals interact with this gene           more ... click here to view the complete list

-  RNA-Seq Expression Data from GTEx (53 Tissues, 570 Donors)
  Highest median expression: 86.57 RPKM in Pancreas
Total median expression: 1832.12 RPKM



View in GTEx track of Genome Browser    View at GTEx portal     View GTEx Body Map

+  Microarray Expression Data
  Press "+" in the title bar above to open this section.

-  mRNA Secondary Structure of 3' and 5' UTRs
 
RegionFold EnergyBasesEnergy/Base
Display As
5' UTR -68.90166-0.415 Picture PostScript Text
3' UTR -616.201826-0.337 Picture PostScript Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

-  Protein Domain and Structure Information
  InterPro Domains: Graphical view of domain structure
IPR024130 - DAP1/DAPL1

ModBase Predicted Comparative 3D Structure on P51397
FrontTopSide
The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.

-  Orthologous Genes in Other Species
  Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
MouseRatZebrafishD. melanogasterC. elegansS. cerevisiae
Genome BrowserGenome BrowserNo orthologGenome BrowserNo orthologNo ortholog
Gene Details     
Gene Sorter     
MGIRGDEnsemblEnsembl  
Protein SequenceProtein Sequence Protein Sequence  
AlignmentAlignment Alignment  

-  Gene Ontology (GO) Annotations with Structured Vocabulary
  Molecular Function:
GO:0070513 death domain binding

Biological Process:
GO:0006914 autophagy
GO:0006915 apoptotic process
GO:0006919 activation of cysteine-type endopeptidase activity involved in apoptotic process
GO:0010507 negative regulation of autophagy
GO:0032088 negative regulation of NF-kappaB transcription factor activity
GO:0034198 cellular response to amino acid starvation
GO:0045892 negative regulation of transcription, DNA-templated
GO:0097190 apoptotic signaling pathway


-  Descriptions from all associated GenBank mRNAs
  BC080565 - Homo sapiens cDNA clone IMAGE:6371185, **** WARNING: chimeric clone ****.
BC002726 - Homo sapiens death-associated protein, mRNA (cDNA clone MGC:3617 IMAGE:3631886), complete cds.
X76105 - H.sapiens DAP-1 mRNA.
AK298670 - Homo sapiens cDNA FLJ55133 complete cds, weakly similar to Death-associated protein 1.
BT006925 - Homo sapiens death-associated protein mRNA, complete cds.
AK311783 - Homo sapiens cDNA, FLJ92044, highly similar to Homo sapiens death-associated protein (DAP), mRNA.
KJ891026 - Synthetic construct Homo sapiens clone ccsbBroadEn_00420 DAP gene, encodes complete protein.
CR542184 - Homo sapiens full open reading frame cDNA clone RZPDo834G0324D for gene DAP, death-associated protein; complete cds, without stopcodon.
AB590487 - Synthetic construct DNA, clone: pFN21AE1588, Homo sapiens DAP gene for death-associated protein, without stop codon, in Flexi system.
JD475725 - Sequence 456749 from Patent EP1572962.
JD433037 - Sequence 414061 from Patent EP1572962.
JD281814 - Sequence 262838 from Patent EP1572962.
JD166983 - Sequence 148007 from Patent EP1572962.
JD156950 - Sequence 137974 from Patent EP1572962.
JD195670 - Sequence 176694 from Patent EP1572962.
JD535935 - Sequence 516959 from Patent EP1572962.
JD076728 - Sequence 57752 from Patent EP1572962.
JD496718 - Sequence 477742 from Patent EP1572962.
JD102441 - Sequence 83465 from Patent EP1572962.
DQ574481 - Homo sapiens piRNA piR-42593, complete sequence.
JD399971 - Sequence 380995 from Patent EP1572962.
JD061337 - Sequence 42361 from Patent EP1572962.
JD470221 - Sequence 451245 from Patent EP1572962.
JD222582 - Sequence 203606 from Patent EP1572962.
JD254847 - Sequence 235871 from Patent EP1572962.
JD205213 - Sequence 186237 from Patent EP1572962.
JD414302 - Sequence 395326 from Patent EP1572962.
JD377931 - Sequence 358955 from Patent EP1572962.
JD346129 - Sequence 327153 from Patent EP1572962.
JD050735 - Sequence 31759 from Patent EP1572962.
JD180531 - Sequence 161555 from Patent EP1572962.
AF056450 - Homo sapiens clone TEA9 Cri-du-chat critical region mRNA.
JD464369 - Sequence 445393 from Patent EP1572962.

-  Other Names for This Gene
  Alternate Gene Symbols: DAP1, DAP1_HUMAN, ENST00000230895.1, ENST00000230895.10, ENST00000230895.2, ENST00000230895.3, ENST00000230895.4, ENST00000230895.5, ENST00000230895.6, ENST00000230895.7, ENST00000230895.8, ENST00000230895.9, NM_004394, P51397, Q6FGC3, Q9BUC9, uc003jez.1, uc003jez.2, uc003jez.3, uc003jez.4, uc003jez.5, uc003jez.6
UCSC ID: ENST00000230895.11
RefSeq Accession: NM_004394
Protein: P51397 (aka DAP1_HUMAN)
CCDS: CCDS3880.1

-  Methods, Credits, and Use Restrictions
  Click here for details on how this gene model was made and data restrictions if any.