Human Gene FABP4 (ENST00000256104.5) Description and Page Index
  Description: Homo sapiens fatty acid binding protein 4 (FABP4), mRNA. (from RefSeq NM_001442)
RefSeq Summary (NM_001442): FABP4 encodes the fatty acid binding protein found in adipocytes. Fatty acid binding proteins are a family of small, highly conserved, cytoplasmic proteins that bind long-chain fatty acids and other hydrophobic ligands. It is thought that FABPs roles include fatty acid uptake, transport, and metabolism. [provided by RefSeq, Jul 2008]. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: SRR5189655.184392.1, BC003672.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA2142670, SAMEA2142680 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## RefSeq Select criteria :: based on single protein-coding transcript ##RefSeq-Attributes-END##
Gencode Transcript: ENST00000256104.5
Gencode Gene: ENSG00000170323.9
Transcript (Including UTRs)
   Position: hg38 chr8:81,478,419-81,483,233 Size: 4,815 Total Exon Count: 4 Strand: -
Coding Region
   Position: hg38 chr8:81,478,865-81,483,167 Size: 4,303 Coding Exon Count: 4 

Page IndexSequence and LinksUniProtKB CommentsMalaCardsCTDRNA-Seq Expression
Microarray ExpressionRNA StructureProtein StructureOther SpeciesGO AnnotationsmRNA Descriptions
PathwaysOther NamesMethods
Data last updated: 2019-09-04

-  Sequence and Links to Tools and Databases
 
Genomic Sequence (chr8:81,478,419-81,483,233)mRNA (may differ from genome)Protein (132 aa)
Gene SorterGenome BrowserOther Species FASTAGene interactionsTable SchemaBioGPS
CGAPEnsemblEntrez GeneExonPrimerGeneCardsHGNC
HPRDLynxMGIneXtProtOMIMPubMed
ReactomeStanford SOURCEUniProtKBWikipedia

-  Comments and Description Text from UniProtKB
  ID: FABP4_HUMAN
DESCRIPTION: RecName: Full=Fatty acid-binding protein, adipocyte; AltName: Full=Adipocyte lipid-binding protein; Short=ALBP; AltName: Full=Adipocyte-type fatty acid-binding protein; Short=A-FABP; Short=AFABP; AltName: Full=Fatty acid-binding protein 4;
FUNCTION: Lipid transport protein in adipocytes. Binds both long chain fatty acids and retinoic acid. Delivers long-chain fatty acids and retinoic acid to their cognate receptors in the nucleus (By similarity).
SUBUNIT: Homodimer. Interacts with PPARG (By similarity). Monomer.
SUBCELLULAR LOCATION: Cytoplasm. Nucleus. Note=Depending on the nature of the ligand, a conformation change exposes a nuclear localization motif and the protein is transported into the nucleus. Subject to constitutive nuclear export (By similarity).
DOMAIN: Forms a beta-barrel structure that accommodates hydrophobic ligands in its interior.
SIMILARITY: Belongs to the calycin superfamily. Fatty-acid binding protein (FABP) family.

-  MalaCards Disease Associations
  MalaCards Gene Search: FABP4
Diseases sorted by gene-association score: pleomorphic lipoma (5), cerebellar liponeurocytoma (4), obesity (2), diabetes mellitus, noninsulin-dependent (1), overnutrition (1)

-  Comparative Toxicogenomics Database (CTD)
  The following chemicals interact with this gene           more ... click here to view the complete list

-  RNA-Seq Expression Data from GTEx (53 Tissues, 570 Donors)
  Highest median expression: 3415.23 RPKM in Adipose - Visceral (Omentum)
Total median expression: 9179.88 RPKM



View in GTEx track of Genome Browser    View at GTEx portal     View GTEx Body Map

+  Microarray Expression Data
  Press "+" in the title bar above to open this section.

-  mRNA Secondary Structure of 3' and 5' UTRs
 
RegionFold EnergyBasesEnergy/Base
Display As
5' UTR -3.4066-0.052 Picture PostScript Text
3' UTR -87.20446-0.196 Picture PostScript Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

-  Protein Domain and Structure Information
  InterPro Domains: Graphical view of domain structure
IPR012674 - Calycin
IPR011038 - Calycin-like
IPR000463 - Fatty_acid-bd
IPR000566 - Lipocln_cytosolic_FA-bd_dom

Pfam Domains:
PF00061 - Lipocalin / cytosolic fatty-acid binding protein family

Protein Data Bank (PDB) 3-D Structure
MuPIT help

1TOU
- X-ray MuPIT

1TOW
- X-ray MuPIT

2HNX
- X-ray MuPIT
To conserve bandwidth, only the images from the first 3 structures are shown.
2NNQ - X-ray MuPIT 3FR2 - X-ray MuPIT 3FR4 - X-ray MuPIT
3FR5 - X-ray MuPIT 3P6C - X-ray MuPIT 3P6D - X-ray MuPIT
3P6E - X-ray MuPIT 3P6F - X-ray MuPIT 3P6G - X-ray MuPIT
3P6H - X-ray MuPIT 3Q6L - X-ray MuPIT 3RZY - X-ray MuPIT


ModBase Predicted Comparative 3D Structure on P15090
FrontTopSide
The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.

-  Orthologous Genes in Other Species
  Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
MouseRatZebrafishD. melanogasterC. elegansS. cerevisiae
Genome BrowserGenome BrowserNo orthologNo orthologNo orthologNo ortholog
Gene Details     
Gene Sorter     
MGIRGD    
Protein SequenceProtein Sequence    
AlignmentAlignment    

-  Gene Ontology (GO) Annotations with Structured Vocabulary
  Molecular Function:
GO:0005504 fatty acid binding
GO:0008289 lipid binding

Biological Process:
GO:0001816 cytokine production
GO:0006469 negative regulation of protein kinase activity
GO:0019433 triglyceride catabolic process
GO:0042632 cholesterol homeostasis
GO:0045892 negative regulation of transcription, DNA-templated
GO:0050727 regulation of inflammatory response
GO:0050729 positive regulation of inflammatory response
GO:0050872 white fat cell differentiation
GO:0050873 brown fat cell differentiation
GO:0071285 cellular response to lithium ion
GO:0071356 cellular response to tumor necrosis factor

Cellular Component:
GO:0005634 nucleus
GO:0005737 cytoplasm
GO:0005811 lipid particle
GO:0005829 cytosol
GO:0070062 extracellular exosome


-  Descriptions from all associated GenBank mRNAs
  BC003672 - Homo sapiens fatty acid binding protein 4, adipocyte, mRNA (cDNA clone MGC:12293 IMAGE:3683235), complete cds.
FJ224319 - Homo sapiens epididymis secretory protein Li 104 (HEL-S-104) mRNA, complete cds.
J02874 - Human adipocyte lipid-binding protein, complete cds.
JD069032 - Sequence 50056 from Patent EP1572962.
CR456903 - Homo sapiens full open reading frame cDNA clone RZPDo834B057D for gene FABP4, fatty acid binding protein 4, adipocyte; complete cds, incl. stopcodon.
BT006809 - Homo sapiens fatty acid binding protein 4, adipocyte mRNA, complete cds.
JF432859 - Synthetic construct Homo sapiens clone IMAGE:100074181 fatty acid binding protein 4, adipocyte (FABP4) gene, encodes complete protein.
KJ891139 - Synthetic construct Homo sapiens clone ccsbBroadEn_00533 FABP4 gene, encodes complete protein.
AB590738 - Synthetic construct DNA, clone: pFN21AE1620, Homo sapiens FABP4 gene for fatty acid binding protein 4, adipocyte, without stop codon, in Flexi system.
DD153954 - New method.

-  Biochemical and Signaling Pathways
  KEGG - Kyoto Encyclopedia of Genes and Genomes
hsa03320 - PPAR signaling pathway

Reactome (by CSHL, EBI, and GO)

Protein P15090 (Reactome details) participates in the following event(s):

R-HSA-163549 phosphorylated HSL dimer + FABP4 -> phosphorylated HSL dimer:FABP4 complex
R-HSA-381309 PPARG:RXRA heterodimer binds to fatty acid-like ligands
R-HSA-5334794 FABPs bind LCFAs
R-HSA-163551 triacylglycerol + H2O -> diacylglycerol + fatty acid
R-HSA-163402 diacylglycerol + H2O -> 2-acylglycerol + fatty acid
R-HSA-163432 cholesterol ester + H2O -> cholesterol + fatty acid
R-HSA-163560 Triglyceride catabolism
R-HSA-381340 Transcriptional regulation of white adipocyte differentiation
R-HSA-8979227 Triglyceride metabolism
R-HSA-1266738 Developmental Biology
R-HSA-556833 Metabolism of lipids
R-HSA-1430728 Metabolism

-  Other Names for This Gene
  Alternate Gene Symbols: FABP4_HUMAN, NM_001442, P15090, Q6IBA1, uc003ycd.1, uc003ycd.2, uc003ycd.3, uc003ycd.4
UCSC ID: uc003ycd.4
RefSeq Accession: NM_001442
Protein: P15090 (aka FABP4_HUMAN)
CCDS: CCDS6230.1

-  Methods, Credits, and Use Restrictions
  Click here for details on how this gene model was made and data restrictions if any.