Human Gene FGF2 (ENST00000644866.2)
  Description: Homo sapiens fibroblast growth factor 2 (FGF2), transcript variant 1, mRNA. (from RefSeq NM_001361665)
RefSeq Summary (NM_001361665): The protein encoded by this gene is a member of the fibroblast growth factor (FGF) family. FGF family members bind heparin and possess broad mitogenic and angiogenic activities. This protein has been implicated in diverse biological processes, such as limb and nervous system development, wound healing, and tumor growth. The mRNA for this gene contains multiple polyadenylation sites, and is alternatively translated from non-AUG (CUG) and AUG initiation codons, resulting in five different isoforms with distinct properties. The CUG-initiated isoforms are localized in the nucleus and are responsible for the intracrine effect, whereas, the AUG-initiated form is mostly cytosolic and is responsible for the paracrine and autocrine effects of this FGF. [provided by RefSeq, Jul 2008].
Gencode Transcript: ENST00000644866.2
Gencode Gene: ENSG00000138685.17
Transcript (Including UTRs)
   Position: hg38 chr4:122,826,831-122,898,236 Size: 71,406 Total Exon Count: 3 Strand: +
Coding Region
   Position: hg38 chr4:122,827,175-122,892,396 Size: 65,222 Coding Exon Count: 3 

Page IndexSequence and LinksUniProtKB CommentsMalaCardsCTDRNA-Seq Expression
Microarray ExpressionRNA StructureProtein StructureOther SpeciesGO AnnotationsmRNA Descriptions
PathwaysOther NamesMethods
Data last updated at UCSC: 2021-01-14 15:32:12

-  Sequence and Links to Tools and Databases
 
Genomic Sequence (chr4:122,826,831-122,898,236)mRNA (may differ from genome)Protein (155 aa)
Gene SorterGenome BrowserOther Species FASTAGene interactionsTable SchemaBioGPS
CGAPEnsemblEntrez GeneExonPrimerGeneCardsHGNC
HPRDLynxMGIneXtProtOMIMPubMed
ReactomeUniProtKBWikipedia

-  Comments and Description Text from UniProtKB
  ID: FGF2_HUMAN
DESCRIPTION: RecName: Full=Fibroblast growth factor 2; Short=FGF-2; AltName: Full=Basic fibroblast growth factor; Short=bFGF; AltName: Full=Heparin-binding growth factor 2; Short=HBGF-2; Flags: Precursor;
FUNCTION: Plays an important role in the regulation of cell survival, cell division, angiogenesis, cell differentiation and cell migration. Functions as potent mitogen in vitro.
BIOPHYSICOCHEMICAL PROPERTIES: pH dependence: Retains almost half of its activity after treatment at pH 2.0 for 3 hours at 20 degrees Celsius; Temperature dependence: Inactivated after 3 minutes at 60 degrees Celsius or 1 minute at 80 degrees Celsius;
SUBUNIT: Monomer. Homodimer. Interacts with FGFR1, FGFR2, FGFR3 and FGFR4. Affinity between fibroblast growth factors (FGFs) and their receptors is increased by heparan sulfate glycosaminoglycans that function as coreceptors. Interacts with CSPG4, FGFBP1 and TEC. Found in a complex with FGFBP1, FGF1 and FGF2.
INTERACTION: P29466:CASP1; NbExp=2; IntAct=EBI-977447, EBI-516667; Q14512:FGFBP1; NbExp=3; IntAct=EBI-977447, EBI-953742; P11362:FGFR1; NbExp=2; IntAct=EBI-977447, EBI-1028277; P21802:FGFR2; NbExp=3; IntAct=EBI-977447, EBI-1028658;
SUBCELLULAR LOCATION: Secreted. Note=Exported from cells by an endoplasmic reticulum (ER)/Golgi-independent mechanism. Unconventional secretion of FGF2 occurs by direct translocation across the plasma membrane.
TISSUE SPECIFICITY: Expressed in granulosa and cumulus cells. Expressed in hepatocellular carcinoma cells, but not in non- cancerous liver tissue.
PTM: Phosphorylation at Tyr-215 regulates FGF2 unconventional secretion.
PTM: Several N-termini starting at positions 94, 125, 126, 132, 143 and 162 have been identified by direct sequencing.
MISCELLANEOUS: This protein binds heparin more strongly than does aFGF.
SIMILARITY: Belongs to the heparin-binding growth factors family.
SEQUENCE CAUTION: Sequence=AAA52448.1; Type=Frameshift; Positions=25, 82, 98, 133; Sequence=AAB21432.2; Type=Frameshift; Positions=25; Sequence=AAB21432.2; Type=Miscellaneous discrepancy; Note=Unusual initiator. The initiator methionine is coded by a non-canonical CTG leucine codon; Sequence=ABO43041.1; Type=Erroneous initiation; Note=Translation N-terminally extended; Sequence=ABO43041.1; Type=Miscellaneous discrepancy; Note=Unusual initiator. The initiator methionine is coded by a non-canonical CTG leucine codon; Sequence=CAA28027.1; Type=Frameshift; Positions=25, 102; Sequence=CAA28027.1; Type=Miscellaneous discrepancy; Note=Unusual initiator. The initiator methionine is coded by a non-canonical CTG leucine codon; Sequence=CAA73868.1; Type=Frameshift; Positions=25; Sequence=CAA73868.1; Type=Miscellaneous discrepancy; Note=Unusual initiator. The initiator methionine is coded by a non-canonical CTG leucine codon; Sequence=EAX05222.1; Type=Erroneous initiation; Note=Translation N-terminally extended; Sequence=EAX05222.1; Type=Miscellaneous discrepancy; Note=Unusual initiator. The initiator methionine is coded by a non-canonical CTG leucine codon;
WEB RESOURCE: Name=NIEHS-SNPs; URL="http://egp.gs.washington.edu/data/fgf2/";

-  MalaCards Disease Associations
  MalaCards Gene Search: FGF2
Diseases sorted by gene-association score: kaposi sarcoma (24), corneal neovascularization (24), adamantinoma of long bones (20), chronic myocardial ischemia (17), apert syndrome (17), juvenile pilocytic astrocytoma (15), limb ischemia (14), mesangial proliferative glomerulonephritis (13), crouzon syndrome (13), moyamoya disease (12), familial glomangioma (10), myelofibrosis with myeloid metaplasia, somatic (10), scleromyxedema (10), vitreoretinopathy, neovascular inflammatory (10), hemangioma (10), juvenile nasopharyngeal angiofibroma (9), keratitis (9), vitreous disease (9), diverticulitis (9), vascular cancer (9), angiodysplasia (8), melorheostosis (8), microvascular complications of diabetes 1 (8), decubitus ulcer (8), chronic ulcer of skin (8), gastric ulcer (7), craniosynostosis (7), kidney cancer (7), spastic paraplegia 25, autosomal recessive (7), adhesive otitis media (7), peritoneal mesothelioma (7), cornea cancer (7), radiation proctitis (7), laryngitis (7), diabetic macular edema (7), endometrial adenocarcinoma (6), clivus chordoma (6), chondroblastoma (6), dry eye syndrome (6), nonspecific interstitial pneumonia (6), dupuytren contracture (6), peripheral artery disease (6), synovial chondromatosis (6), cholesteatoma of middle ear (6), skin melanoma (6), osteochondroma (6), neuroma (6), bladder cancer, somatic (6), brain compression (5), microvascular complications of diabetes 5 (5), pericardial effusion (5), idiopathic hypercalciuria (5), diffuse glomerulonephritis (5), bladder squamous cell carcinoma (5), colon adenoma (5), endometrial cancer (5), vitiligo-associated multiple autoimmune disease susceptibility 1 (5), hepatocellular carcinoma (4), glioma (4), bone fracture (4), space motion sickness (4), infiltrating lipoma (4), angiomatous meningioma (4), cecum adenocarcinoma (4), lacrimal gland adenocarcinoma (4), malignant glioma (4), glomangioma (4), carbuncle (4), cardiovascular organ benign neoplasm (4), benign perivascular tumor (4), chondrosarcoma (4), vascular disease (4), disuse amblyopia (4), teratocarcinoma (4), breast cancer (3), congenital muscular dystrophy due to lmna mutation (3), melanoma (3), ecthyma (3), muenke syndrome (3), fibrosarcoma (3), pancreatic cancer (3), lung cancer (3), prostate cancer (3), renal cell carcinoma (2), macular degeneration, age-related, 1 (2), mesothelioma, somatic (2), colorectal cancer (2), chronic lymphocytic leukemia (2), connective tissue cancer (1), squamous cell carcinoma, head and neck (1), pilocytic astrocytoma (1), pulmonary fibrosis, idiopathic (1)

-  Comparative Toxicogenomics Database (CTD)
  The following chemicals interact with this gene           more ... click here to view the complete list

-  RNA-Seq Expression Data from GTEx (53 Tissues, 570 Donors)
  Highest median expression: 12.54 RPKM in Cells - Cultured fibroblasts
Total median expression: 76.00 RPKM



View in GTEx track of Genome Browser    View at GTEx portal     View GTEx Body Map

+  Microarray Expression Data
  Press "+" in the title bar above to open this section.

-  mRNA Secondary Structure of 3' and 5' UTRs
 
RegionFold EnergyBasesEnergy/Base
Display As
5' UTR -219.60344-0.638 Picture PostScript Text
3' UTR -1385.375840-0.237 Picture PostScript Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

-  Protein Domain and Structure Information
  InterPro Domains: Graphical view of domain structure
IPR008996 - Cytokine_IL1-like
IPR002209 - GF_heparin-bd
IPR002348 - IL1_HBGF

Pfam Domains:
PF00167 - Fibroblast growth factor

Protein Data Bank (PDB) 3-D Structure
MuPIT help

1BAS
- X-ray MuPIT

1BFB
- X-ray

1BFC
- X-ray
To conserve bandwidth, only the images from the first 3 structures are shown.
1BFF - X-ray MuPIT 1BFG - X-ray MuPIT 1BLA - NMR MuPIT
1BLD - NMR MuPIT 1CVS - X-ray MuPIT 1EV2 - X-ray MuPIT
1FGA - X-ray MuPIT 1FQ9 - X-ray MuPIT 1II4 - X-ray MuPIT
1IIL - X-ray MuPIT 2BFH - X-ray MuPIT 2FGF - X-ray MuPIT
4FGF - X-ray MuPIT


ModBase Predicted Comparative 3D Structure on P09038
FrontTopSide
The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.

-  Orthologous Genes in Other Species
  Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
MouseRatZebrafishD. melanogasterC. elegansS. cerevisiae
Genome BrowserGenome BrowserNo orthologNo orthologNo orthologNo ortholog
Gene Details     
Gene Sorter     
MGIRGD    
Protein SequenceProtein Sequence    
AlignmentAlignment    

-  Gene Ontology (GO) Annotations with Structured Vocabulary
  Molecular Function:
GO:0004713 protein tyrosine kinase activity
GO:0005088 Ras guanyl-nucleotide exchange factor activity
GO:0005104 fibroblast growth factor receptor binding
GO:0005125 cytokine activity
GO:0005178 integrin binding
GO:0005515 protein binding
GO:0008083 growth factor activity
GO:0008201 heparin binding
GO:0016303 1-phosphatidylinositol-3-kinase activity
GO:0030374 ligand-dependent nuclear receptor transcription coactivator activity
GO:0042056 chemoattractant activity
GO:0046934 phosphatidylinositol-4,5-bisphosphate 3-kinase activity
GO:0090722 receptor-receptor interaction

Biological Process:
GO:0000165 MAPK cascade
GO:0000187 activation of MAPK activity
GO:0001525 angiogenesis
GO:0001658 branching involved in ureteric bud morphogenesis
GO:0001938 positive regulation of endothelial cell proliferation
GO:0002042 cell migration involved in sprouting angiogenesis
GO:0006661 phosphatidylinositol biosynthetic process
GO:0006935 chemotaxis
GO:0007165 signal transduction
GO:0007265 Ras protein signal transduction
GO:0007275 multicellular organism development
GO:0007399 nervous system development
GO:0008284 positive regulation of cell proliferation
GO:0008543 fibroblast growth factor receptor signaling pathway
GO:0009887 animal organ morphogenesis
GO:0010469 regulation of receptor activity
GO:0010764 negative regulation of fibroblast migration
GO:0010863 positive regulation of phospholipase C activity
GO:0014843 growth factor dependent regulation of skeletal muscle satellite cell proliferation
GO:0018108 peptidyl-tyrosine phosphorylation
GO:0019221 cytokine-mediated signaling pathway
GO:0030154 cell differentiation
GO:0030198 extracellular matrix organization
GO:0030214 hyaluronan catabolic process
GO:0032958 inositol phosphate biosynthetic process
GO:0035019 somatic stem cell population maintenance
GO:0036092 phosphatidylinositol-3-phosphate biosynthetic process
GO:0042060 wound healing
GO:0042660 positive regulation of cell fate specification
GO:0043406 positive regulation of MAP kinase activity
GO:0043536 positive regulation of blood vessel endothelial cell migration
GO:0043537 negative regulation of blood vessel endothelial cell migration
GO:0043552 positive regulation of phosphatidylinositol 3-kinase activity
GO:0045765 regulation of angiogenesis
GO:0045766 positive regulation of angiogenesis
GO:0045893 positive regulation of transcription, DNA-templated
GO:0045944 positive regulation of transcription from RNA polymerase II promoter
GO:0046854 phosphatidylinositol phosphorylation
GO:0048598 embryonic morphogenesis
GO:0050918 positive chemotaxis
GO:0051209 release of sequestered calcium ion into cytosol
GO:0051781 positive regulation of cell division
GO:0051897 positive regulation of protein kinase B signaling
GO:0060045 positive regulation of cardiac muscle cell proliferation
GO:0060548 negative regulation of cell death
GO:0060591 chondroblast differentiation
GO:0061045 negative regulation of wound healing
GO:0070374 positive regulation of ERK1 and ERK2 cascade
GO:0072089 stem cell proliferation
GO:0090050 positive regulation of cell migration involved in sprouting angiogenesis
GO:1903672 positive regulation of sprouting angiogenesis
GO:1904707 positive regulation of vascular smooth muscle cell proliferation
GO:1905564 positive regulation of vascular endothelial cell proliferation
GO:2000544 regulation of endothelial cell chemotaxis to fibroblast growth factor
GO:2000546 positive regulation of endothelial cell chemotaxis to fibroblast growth factor

Cellular Component:
GO:0005576 extracellular region
GO:0005615 extracellular space
GO:0005634 nucleus


-  Descriptions from all associated GenBank mRNAs
  J04513 - Human basic fibroblast growth factor (bFGF) 22.5 kd, 21 kd and 18 kd protein mRNA, complete cds.
BC111737 - Homo sapiens cDNA clone IMAGE:40036434.
BC118573 - Homo sapiens cDNA clone IMAGE:40036436.
BC118654 - Homo sapiens cDNA clone IMAGE:40036435.
BC166646 - Synthetic construct Homo sapiens clone IMAGE:100066372, MGC:195509 fibroblast growth factor 2 (basic) (FGF2) mRNA, encodes complete protein.
E01662 - cDNA encoding human basic fibroblast grouth factor.
M27968 - Human basic fibroblast growth factor (FGF) mRNA, complete cds.
JD200003 - Sequence 181027 from Patent EP1572962.
JD156316 - Sequence 137340 from Patent EP1572962.
JD187763 - Sequence 168787 from Patent EP1572962.
JD076421 - Sequence 57445 from Patent EP1572962.
JD520428 - Sequence 501452 from Patent EP1572962.
M17599 - Human basic fibroblast growth factor (bFGF) mRNA, partial cds.
AB451450 - Homo sapiens FGF2 mRNA for heparin-binding growth factor 2 precursor, partial cds, clone: FLJ08202AAAF.
AB451321 - Homo sapiens FGF2 mRNA for heparin-binding growth factor 2 precursor, complete cds, clone: FLJ08202AAAN.
E05101 - cDNA encoding human basic fibroblast growth factor.
E05102 - cDNA encoding human basic fibroblast growth factor.
E02144 - Human basic fibroblast growth factor gene and its derivative.
E02544 - cDNA sequence of human basic fibroblast growth factor.
E03194 - DNA encoding rhbFGF(recombinant human basic fibroblast growth factor).
E04552 - cDNA encoding human basic fibroblast growth factor.
E05628 - cDNA encoding human basic FGF.
E05629 - cDNA encoding improved human basic FGF.
E05630 - cDNA encoding improved human basic FGF.
E05631 - cDNA encoding improved human basic FGF.
E05632 - cDNA encoding improved human basic FGF.
HF548200 - Synthetic construct for SP1-fibroblast growth factor 2 fusion protein.
AY820133 - Homo sapiens basic fibroblast growth factor mRNA, partial cds.
S47380 - basic fibroblast growth factor bFGF [human, granulosa cells, mRNA Partial, 266 nt].
JD363679 - Sequence 344703 from Patent EP1572962.
JD509987 - Sequence 491011 from Patent EP1572962.
JD546881 - Sequence 527905 from Patent EP1572962.
JD295632 - Sequence 276656 from Patent EP1572962.
JD324211 - Sequence 305235 from Patent EP1572962.
JD102174 - Sequence 83198 from Patent EP1572962.
JD285738 - Sequence 266762 from Patent EP1572962.
JD567095 - Sequence 548119 from Patent EP1572962.
JD552046 - Sequence 533070 from Patent EP1572962.
JD066912 - Sequence 47936 from Patent EP1572962.
JD037648 - Sequence 18672 from Patent EP1572962.
JD302829 - Sequence 283853 from Patent EP1572962.
JD396081 - Sequence 377105 from Patent EP1572962.
JD347040 - Sequence 328064 from Patent EP1572962.
JD463749 - Sequence 444773 from Patent EP1572962.
JD249704 - Sequence 230728 from Patent EP1572962.
JD561287 - Sequence 542311 from Patent EP1572962.
JD481171 - Sequence 462195 from Patent EP1572962.
JD481172 - Sequence 462196 from Patent EP1572962.
JD552063 - Sequence 533087 from Patent EP1572962.
JD471765 - Sequence 452789 from Patent EP1572962.
JD179259 - Sequence 160283 from Patent EP1572962.
JD179260 - Sequence 160284 from Patent EP1572962.
JD188549 - Sequence 169573 from Patent EP1572962.
JD360885 - Sequence 341909 from Patent EP1572962.
JD499626 - Sequence 480650 from Patent EP1572962.
JD090593 - Sequence 71617 from Patent EP1572962.
JD545986 - Sequence 527010 from Patent EP1572962.
JD498338 - Sequence 479362 from Patent EP1572962.
JD431249 - Sequence 412273 from Patent EP1572962.
JD533376 - Sequence 514400 from Patent EP1572962.
JD180197 - Sequence 161221 from Patent EP1572962.
JD341752 - Sequence 322776 from Patent EP1572962.
JD479445 - Sequence 460469 from Patent EP1572962.
JD479446 - Sequence 460470 from Patent EP1572962.
JD046124 - Sequence 27148 from Patent EP1572962.
JD532170 - Sequence 513194 from Patent EP1572962.
JD082954 - Sequence 63978 from Patent EP1572962.
JD238617 - Sequence 219641 from Patent EP1572962.
JD048040 - Sequence 29064 from Patent EP1572962.
JD352064 - Sequence 333088 from Patent EP1572962.
JD257685 - Sequence 238709 from Patent EP1572962.
JD144024 - Sequence 125048 from Patent EP1572962.
JD230112 - Sequence 211136 from Patent EP1572962.
JD364653 - Sequence 345677 from Patent EP1572962.
JD367720 - Sequence 348744 from Patent EP1572962.
JD459562 - Sequence 440586 from Patent EP1572962.
JD369144 - Sequence 350168 from Patent EP1572962.
JD284283 - Sequence 265307 from Patent EP1572962.
JD056330 - Sequence 37354 from Patent EP1572962.
JD187607 - Sequence 168631 from Patent EP1572962.
JD302758 - Sequence 283782 from Patent EP1572962.
JD221185 - Sequence 202209 from Patent EP1572962.
JD233765 - Sequence 214789 from Patent EP1572962.
JD048871 - Sequence 29895 from Patent EP1572962.
JD178807 - Sequence 159831 from Patent EP1572962.
JD236365 - Sequence 217389 from Patent EP1572962.
JD297123 - Sequence 278147 from Patent EP1572962.
JD309065 - Sequence 290089 from Patent EP1572962.
JD403030 - Sequence 384054 from Patent EP1572962.
JD052796 - Sequence 33820 from Patent EP1572962.
JD346920 - Sequence 327944 from Patent EP1572962.
JD206635 - Sequence 187659 from Patent EP1572962.
JD315095 - Sequence 296119 from Patent EP1572962.
JD315718 - Sequence 296742 from Patent EP1572962.
JD171335 - Sequence 152359 from Patent EP1572962.
JD502075 - Sequence 483099 from Patent EP1572962.
JD053730 - Sequence 34754 from Patent EP1572962.
JD566670 - Sequence 547694 from Patent EP1572962.
JD300201 - Sequence 281225 from Patent EP1572962.
JD527420 - Sequence 508444 from Patent EP1572962.
JD304381 - Sequence 285405 from Patent EP1572962.

-  Biochemical and Signaling Pathways
  KEGG - Kyoto Encyclopedia of Genes and Genomes
hsa04010 - MAPK signaling pathway
hsa04810 - Regulation of actin cytoskeleton
hsa05200 - Pathways in cancer
hsa05218 - Melanoma

BioCarta from NCI Cancer Genome Anatomy Project
h_nfatPathway - NFAT and Hypertrophy of the heart (Transcription in the broken heart)

Reactome (by CSHL, EBI, and GO)

Protein P09038 (Reactome details) participates in the following event(s):

R-HSA-2684507 Syndecans 1, 2, 4, (3) bind FGF2
R-HSA-190256 FGFR1c binds to FGF
R-HSA-2023451 FGFR1c P252X mutants bind ligand with enhanced affinity
R-HSA-190261 FGFR3c binds to FGF
R-HSA-2012074 FGFR3c P250R mutant binds to ligand with enhanced affinity
R-HSA-190265 FGFR4 binds to FGF
R-HSA-190245 FGFR1b binds to FGF
R-HSA-2033474 FGFR2b mutants bind an expanded range of ligands
R-HSA-2077421 FP-1039 acts as a ligand-trap for FGFR2b-binding ligands in endometrial cancer
R-HSA-2396337 HSPG2 binds FGF2(10-155), Fibronectn matrix, Transthyretin tetramer, PDGFA homodimer, PDGFB homodimer
R-HSA-5656070 FGFBPs bind FGFs
R-HSA-8853320 FGFR2IIIa TM binds ligand and full length receptors to inhibit signaling
R-NUL-8853328 Mouse FGFR2 IIIa TM binds FGF1,2 and full-length receptors
R-HSA-5654511 FGFRL1 dimer binds FGFs
R-HSA-190429 Autocatalytic phosphorylation of FGFR1c
R-HSA-2023455 Autocatalytic phosphorylation of FGFR1c P252X mutant dimers
R-HSA-190388 Autocatalytic phosphorylation of FGFR3c
R-HSA-2012073 Autocatalytic phosphorylation of FGFR3c P250R mutant
R-HSA-2033472 FGFR2c mutants bind an expanded range of ligands
R-HSA-190326 Autocatalytic phosphorylation of FGFR4
R-HSA-190427 Autocatalytic phosphorylation of FGFR1b
R-HSA-2033488 Autocatalytic phosphorylation of FGFR2b mutants with enhanced ligand binding
R-HSA-5654167 Activated FGFR1 binds PLCG1
R-HSA-5654569 Activated FGFR1 binds FRS2
R-HSA-5654571 Activated FGFR1 binds FRS3
R-HSA-5654573 Activated FGFR1 binds SHC1
R-HSA-5656064 Activated FGFR1 binds FLRT1,2,3
R-HSA-5654165 p-4Y-PLCG1 dissociates from activated FGFR1
R-HSA-5655269 Activated FGFR1 mutants bind FRS2
R-HSA-5654224 Activated FGFR3 binds PLCG1
R-HSA-5654409 Activated FGFR3 binds FRS2
R-HSA-5654623 Activated FGFR3 binds FRS3
R-HSA-5654625 Activated FGFR3 binds SHC1
R-HSA-5654148 p-4Y-PLCG1 dissociates from activated FGFR3
R-HSA-2077420 FGFR3 mutants bind and are inactivated by tyrosine kinase inhibitors
R-HSA-5655244 Activated FGFR3 mutants bind PLCG1
R-HSA-5655262 Activated FGFR3 mutants bind FRS2
R-HSA-5655247 p-4Y-PLCG1 dissociates from activated FGFR3 mutants
R-HSA-190413 Autocatalytic phosphorylation of FGFR2c
R-HSA-2033486 Autocatalytic phosphorylation of FGFR2c mutants with enhanced ligand binding
R-HSA-5654163 Activated FGFR4 binds PLCG1
R-HSA-5654422 Activated FGFR4 binds FRS2
R-HSA-5654425 Activated FGFR4 binds SHC1
R-HSA-5654651 Activated FGFR4 binds FRS3
R-HSA-5654169 p-4Y-PLCG1 dissociates from activated FGFR4
R-HSA-2077424 Point mutants of FGFR2 bind and are inactivated by tyrosine kinase inhibitors
R-HSA-5655339 Activated FGFR2 mutants bind FRS2
R-HSA-5655343 Activated FGFR2 mutants bind PLCG1
R-HSA-5654748 p-4Y-PLCG1 dissociates from activated FGFR2 mutants
R-HSA-5654149 Activated FGFR1 phosphorylates PLCG1
R-HSA-5654560 Activated ERK1/2 threonine-phosphorylates FGFR1-associated FRS2.
R-HSA-5654575 Activated FGFR1 phosphorylates FRS2
R-HSA-5654592 Activated FGFR1:p-FRS2 binds GRB2:GAB1:PIK3R1
R-HSA-5654578 Activated FGFR1 phosphorylates FRS3
R-HSA-5654582 Activated FGFR1 phosphorylates SHC1
R-HSA-5654597 Activated FGFR1:p-SHC1 binds GRB2:SOS1
R-HSA-5655240 Activated FGFR1 mutants:p-FRS2 binds GRB2:GAB1:PIK3R1
R-HSA-5655266 Activated FGFR1 mutants:p-FRS2 binds GRB2-SOS1
R-HSA-5655278 Activated FGFR1 mutants phosphorylate FRS2
R-HSA-1839094 Activated FGFR1 mutants and fusions bind PLCG1
R-HSA-1839100 p-4Y- PLCG1 dissociates from activated FGFR1 mutants and fusions
R-HSA-5654222 Activated FGFR3 phosphorylates PLCG1
R-HSA-5654408 Activated FGFR3 phosphorylates FRS2
R-HSA-5654565 Activated ERK1/2 threonine-phosphorylates FGFR3-associated FRS2.
R-HSA-5654637 Activated FGFR3:p-FRS2 binds GRB2:GAB1:PIK3R1
R-HSA-5654628 Activated FGFR3 phosphorylates FRS3
R-HSA-5654634 Activated FGFR3 phosphorylates SHC1
R-HSA-5654646 Activated FGFR3:p-SHC1 binds GRB2:SOS1
R-HSA-5655295 Activated FGFR3 mutants:p-FRS2 binds GRB2-SOS1
R-HSA-5655315 Activated FGFR3 mutants:p-FRS2 binds GRB2:GAB1:PIK3R1
R-HSA-5655270 Activated FGFR3 mutants phosphorylate FRS2
R-HSA-5655243 Activated FGFR3 mutants phosphorylate PLCG1
R-HSA-5654159 Activated FGFR2 binds PLCG1
R-HSA-5654399 Activated FGFR2 binds FRS2
R-HSA-5654404 Activated FGFR2 binds SHC1
R-HSA-5654603 Activated FGFR2 binds FRS3
R-HSA-5654157 p-4Y-PLCG1 dissociates from activated FGFR2
R-HSA-5654151 Activated FGFR4 phosphorylates PLCG1
R-HSA-5654418 Activated FGFR4 phosphorylates FRS2
R-HSA-5654566 Activated ERK1/2 threonine-phosphorylates FGFR4-associated FRS2.
R-HSA-5654659 Activated FGFR4:p-FRS2 binds GRB2:GAB1:PIK3R1
R-HSA-5654653 Activated FGFR4 phosphorylates FRS3
R-HSA-5654428 Activated FGFR4 phosphorylates SHC1
R-HSA-5654423 Activated FGFR4:p-SHC1 binds GRB2:SOS1
R-HSA-5655301 Activated FGFR2 mutants phosphorylate PLCG1
R-HSA-5655233 Activated FGFR2 mutants:p-FRS2 binds GRB2-SOS1
R-HSA-5655320 Activated FGFR2 mutants:p-FRS2 binds GRB2:GAB1:PIK3R1
R-HSA-5655268 Activated FGFR2 mutants phosphorylate FRS2
R-HSA-5654591 Activated FGFR1:p-FRS2:GRB2:GAB1:PI3KR1 binds PIK3CA
R-HSA-5654594 Activated FGFR1:p-FRS2:p-PPTN11 binds GRB2:GAB1:PI3KR1
R-HSA-5654673 p-CBL:GRB2 binds p-FRS2:activated FGFR1
R-HSA-5654584 Activated FGFR1:p-FRS bind to PPTN11
R-HSA-5654586 Activated FGFR1:p-FRS binds GRB2:SOS1
R-HSA-5655263 Activated FGFR1 mutants:p-FRS2:GRB2:GAB1:PIK3R1 binds PIK3CA
R-HSA-1839098 Activated FGFR1 mutants and fusions phosphorylate PLCG1
R-HSA-5654641 Activated FGFR3:p-FRS2:p-PPTN11 binds GRB2:GAB1:PI3KR1
R-HSA-5654730 p-CBL:GRB2 binds p-FRS2:activated FGFR3
R-HSA-5654640 Activated FGFR3:p-FRS2:GRB2:GAB1:PI3KR1 binds PIK3CA
R-HSA-5654416 Activated FGFR3:pFRS binds GRB2:SOS1
R-HSA-5654633 Activated FGFR3:p-FRS bind to PPTN11
R-HSA-5655285 Activated FGFR3 mutants:p-FRS2:GRB2:GAB1:PIK3R1 binds PIK3CA
R-HSA-5654147 Activated FGFR2 phosphorylates PLCG1
R-HSA-5654397 Activated FGFR2 phosphorylates FRS2
R-HSA-5654562 Activated ERK1/2 threonine-phosphorylates FGFR2-associated FRS2
R-HSA-5654612 Activated FGFR2:p-FRS2 binds GRB2:GAB1:PIK3R1
R-HSA-5654605 Activated FGFR2 phosphorylates FRS3
R-HSA-5654407 Activated FGFR2 phosphorylates SHC1
R-HSA-5654406 Activated FGFR2:p-SHC1 binds GRB2:SOS1
R-HSA-5654662 Activated FGFR4:p-FRS2:GRB2:GAB1:PI3KR1 binds PIK3CA
R-HSA-5654667 Activated FGFR4:p-FRS2:p-PPTN11 binds GRB2:GAB1:PI3KR1
R-HSA-5654734 p-CBL:GRB2 binds p-FRS2:activated FGFR4
R-HSA-5654658 Activated FGFR4:p-FRS bind to PPTN11
R-HSA-5654664 Activated FGFR4:p-FRS binds GRB2:SOS1
R-HSA-5655245 Activated FGFR2 mutants:p-FRS2:GRB2:GAB1:PIK3R1 binds PIK3CA
R-HSA-5654596 Activated FGFR1:p-FRS2:p-PPTN11:GRB2:GAB1:PIK3R1 binds PIK3CA
R-HSA-5654672 CBL ubiquitinates FRS2 and FGFR1
R-HSA-5654587 Activated FGFR1:p-FRS phosphorylates PPTN11
R-HSA-5654600 Activated FGFR1:p-SHC1:GRB2:SOS1 activates RAS nucleotide exchange
R-HSA-5655326 Activated FGFR1 mutants:p-FRS2:GRB2:SOS1 activates RAS nucleotide exchange
R-HSA-5654643 Activated FGFR3:p-FRS2:p-PPTN11:GRB2:GAB1:PIK3R1 binds PIK3CA
R-HSA-5654679 CBL ubiquitinates FRS2 and FGFR3
R-HSA-5654631 Activated FGFR3 phosphorylates PPTN11
R-HSA-5654647 Activated FGFR3:p-SHC1:GRB2:SOS1 activates RAS nucleotide exchange
R-HSA-5655277 Activated FGFR3 mutants:p-FRS2:GRB2:SOS1 activates RAS nucleotide exchange
R-HSA-5654620 Activated FGFR2:p-FRS2:p-PPTN11 binds GRB2:GAB1:PI3KR1
R-HSA-5654729 p-CBL:GRB2 binds p-FRS2:activated FGFR2
R-HSA-5654614 Activated FGFR2:p-FRS2:GRB2:GAB1:PI3KR1 binds PIK3CA
R-HSA-5654608 Activated FGFR2:p-FRS bind to PPTN11
R-HSA-5654615 Activated FGFR2:pFRS binds GRB2:SOS1
R-HSA-5654669 Activated FGFR4:p-FRS2:p-PPTN11:GRB2:GAB1:PIK3R1binds PIK3CA
R-HSA-5654684 CBL ubiquitinates FRS2 and FGFR4
R-HSA-5654655 Activated FGFR4 phosphorylates PPTN11
R-HSA-5654426 Activated FGFR4:p-SHC1:GRB2:SOS1 activates RAS nucleotide exchange
R-HSA-5655241 Activated FGFR2 mutants:p-FRS2:GRB2:SOS1 activates RAS nucleotide exchange
R-HSA-5654690 FGFR1-associated PI3K phosphorylates PIP2 to PIP3
R-HSA-5654392 Activated FGFR1:p-FRS:GRB2:SOS1 activates RAS nucleotide exchange
R-HSA-5672965 RAS GEFs promote RAS nucleotide exchange
R-HSA-5655290 Activated FGFR1 mutant-associated PI3K phosphorylates PIP2 to PIP3
R-HSA-5654705 FGFR3-associated PI3K phosphorylates PIP2 to PIP3
R-HSA-5654413 Activated FGFR3:p-FRS2:GRB2:SOS1 activates RAS nucleotide exchange
R-HSA-5655289 Activated FGFR3 mutant-associated PI3K phosphorylates PIP2 to PIP3
R-HSA-5654622 Activated FGFR2:p-FRS2:p-PPTN11:GRB2:GAB1:PIK3R1 binds PIK3CA
R-HSA-5654677 CBL ubiquitinates FRS2 and FGFR2
R-HSA-5654607 Activated FGFR2 phosphorylates PPTN11
R-HSA-5654402 Activated FGFR2:p-SHC1:GRB2:SOS1 activates RAS nucleotide exchange
R-HSA-5654717 FGFR4-associated PI3K phosphorylates PIP2 to PIP3
R-HSA-5654663 Activated FGFR4:p-FRS2:GRB2:SOS1 activates RAS nucleotide exchange
R-HSA-5655323 Activated FGFR2 mutant-associated PI3K phosphorylates PIP2 to PIP3
R-HSA-2400009 PI3K inhibitors block PI3K catalytic activity
R-HSA-2316434 PI3K phosphorylates PIP2 to PIP3
R-HSA-5654692 FGFR1- and PTPN11- associated PI3K phosphorylates PIP2 to PIP3
R-HSA-5654709 FGFR3- and PTPN11-associated PI3K phosphorylates PIP2 to PIP3
R-HSA-5654701 FGFR2-associated PI3K phosphorylates PIP2 to PIP3
R-HSA-5654618 Activated FGFR2:p-FRS2:GRB2:SOS1 activates RAS nucleotide exchange
R-HSA-5654714 FGFR4- and PTPN11-associated PI3K phosphorylates PIP2 to PIP3
R-HSA-109699 PI3K-containing complexes phosphorylate PIP2 to PIP3
R-HSA-5654697 FGFR2- and PTPN11- associated PI3K phosphorylates PIP2 to PIP3
R-HSA-3000170 Syndecan interactions
R-HSA-2892247 POU5F1 (OCT4), SOX2, NANOG activate genes related to proliferation
R-HSA-190373 FGFR1c ligand binding and activation
R-HSA-1839122 Signaling by activated point mutants of FGFR1
R-HSA-190372 FGFR3c ligand binding and activation
R-HSA-1839130 Signaling by activated point mutants of FGFR3
R-HSA-190375 FGFR2c ligand binding and activation
R-HSA-190322 FGFR4 ligand binding and activation
R-HSA-190370 FGFR1b ligand binding and activation
R-HSA-2033519 Activated point mutants of FGFR2
R-HSA-3000171 Non-integrin membrane-ECM interactions
R-HSA-190377 FGFR2b ligand binding and activation
R-HSA-6785807 Interleukin-4 and 13 signaling
R-HSA-8851708 Signaling by FGFR2 IIIa TM
R-HSA-5658623 FGFRL1 modulation of FGFR1 signaling
R-HSA-452723 Transcriptional regulation of pluripotent stem cells
R-HSA-190242 FGFR1 ligand binding and activation
R-HSA-1839124 FGFR1 mutant receptor activation
R-HSA-190239 FGFR3 ligand binding and activation
R-HSA-2033514 FGFR3 mutant receptor activation
R-HSA-190241 FGFR2 ligand binding and activation
R-HSA-5654743 Signaling by FGFR4
R-HSA-1839126 FGFR2 mutant receptor activation
R-HSA-1474244 Extracellular matrix organization
R-HSA-449147 Signaling by Interleukins
R-HSA-5654736 Signaling by FGFR1
R-HSA-1266738 Developmental Biology
R-HSA-5654219 Phospholipase C-mediated cascade: FGFR1
R-HSA-5654693 FRS-mediated FGFR1 signaling
R-HSA-5654688 SHC-mediated cascade:FGFR1
R-HSA-5654687 Downstream signaling of activated FGFR1
R-HSA-5655302 Signaling by FGFR1 in disease
R-HSA-5654227 Phospholipase C-mediated cascade; FGFR3
R-HSA-5654706 FRS-mediated FGFR3 signaling
R-HSA-5654704 SHC-mediated cascade:FGFR3
R-HSA-8853338 Signaling by FGFR3 point mutants in cancer
R-HSA-5654741 Signaling by FGFR3
R-HSA-5654738 Signaling by FGFR2
R-HSA-5654228 Phospholipase C-mediated cascade; FGFR4
R-HSA-5654712 FRS-mediated FGFR4 signaling
R-HSA-5654719 SHC-mediated cascade:FGFR4
R-HSA-190236 Signaling by FGFR
R-HSA-5655253 Signaling by FGFR2 in disease
R-HSA-1280215 Cytokine Signaling in Immune system
R-HSA-5654726 Negative regulation of FGFR1 signaling
R-HSA-5654689 PI-3K cascade:FGFR1
R-HSA-1226099 Signaling by FGFR in disease
R-HSA-5654732 Negative regulation of FGFR3 signaling
R-HSA-5654710 PI-3K cascade:FGFR3
R-HSA-5654708 Downstream signaling of activated FGFR3
R-HSA-5655332 Signaling by FGFR3 in disease
R-HSA-5654221 Phospholipase C-mediated cascade; FGFR2
R-HSA-5654700 FRS-mediated FGFR2 signaling
R-HSA-5654699 SHC-mediated cascade:FGFR2
R-HSA-5654733 Negative regulation of FGFR4 signaling
R-HSA-5654720 PI-3K cascade:FGFR4
R-HSA-5654716 Downstream signaling of activated FGFR4
R-HSA-9006934 Signaling by Receptor Tyrosine Kinases
R-HSA-168256 Immune System
R-HSA-5663202 Diseases of signal transduction
R-HSA-5654727 Negative regulation of FGFR2 signaling
R-HSA-5654695 PI-3K cascade:FGFR2
R-HSA-5654696 Downstream signaling of activated FGFR2
R-HSA-162582 Signal Transduction
R-HSA-1643685 Disease
R-HSA-5673001 RAF/MAP kinase cascade
R-HSA-2219530 Constitutive Signaling by Aberrant PI3K in Cancer
R-HSA-1257604 PIP3 activates AKT signaling
R-HSA-6811558 PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling
R-HSA-5684996 MAPK1/MAPK3 signaling
R-HSA-109704 PI3K Cascade
R-HSA-2219528 PI3K/AKT Signaling in Cancer
R-HSA-9006925 Intracellular signaling by second messengers
R-HSA-199418 Negative regulation of the PI3K/AKT network
R-HSA-5683057 MAPK family signaling cascades
R-HSA-112399 IRS-mediated signalling
R-HSA-74751 Insulin receptor signalling cascade
R-HSA-2428928 IRS-related events triggered by IGF1R
R-HSA-74752 Signaling by Insulin receptor
R-HSA-2428924 IGF1R signaling cascade
R-HSA-2404192 Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R)

-  Other Names for This Gene
  Alternate Gene Symbols: A4LBB8, ENST00000644866.1, FGF2_HUMAN, FGFB, NM_001361665, O00527, P09038, P78443, Q16443, Q5PY50, Q7KZ11, Q7KZ72, Q9UC54, Q9UCS5, Q9UCS6, uc285wtz.1
UCSC ID: ENST00000644866.2
RefSeq Accession: NM_001361665
Protein: P09038 (aka FGF2_HUMAN)

-  Methods, Credits, and Use Restrictions
  Click here for details on how this gene model was made and data restrictions if any.