ID:GPA33_HUMAN DESCRIPTION: RecName: Full=Cell surface A33 antigen; AltName: Full=Glycoprotein A33; Flags: Precursor; FUNCTION: May play a role in cell-cell recognition and signaling. SUBCELLULAR LOCATION: Membrane; Single-pass type I membrane protein. TISSUE SPECIFICITY: Expressed in normal gastrointestinal epithelium and in 95% of colon cancers. PTM: N-glycosylated, contains approximately 8 kDa of N-linked carbohydrate. PTM: Palmitoylated. SIMILARITY: Contains 1 Ig-like C2-type (immunoglobulin-like) domain. SIMILARITY: Contains 1 Ig-like V-type (immunoglobulin-like) domain. WEB RESOURCE: Name=Atlas of Genetics and Cytogenetics in Oncology and Haematology; URL="http://atlasgeneticsoncology.org//Genes/GPA33ID40735ch1q23.html";
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
ModBase Predicted Comparative 3D Structure on Q99795
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
Gene Ontology (GO) Annotations with Structured Vocabulary
Molecular Function: GO:0005515 protein binding GO:0038023 signaling receptor activity
Biological Process: GO:0007165 signal transduction
Cellular Component: GO:0005887 integral component of plasma membrane GO:0016020 membrane GO:0016021 integral component of membrane GO:0070062 extracellular exosome
Descriptions from all associated GenBank mRNAs
U79725 - Human A33 antigen precursor mRNA, complete cds. JD552224 - Sequence 533248 from Patent EP1572962. BC069705 - Homo sapiens glycoprotein A33 (transmembrane), mRNA (cDNA clone MGC:97280 IMAGE:7262529), complete cds. BC069723 - Homo sapiens glycoprotein A33 (transmembrane), mRNA (cDNA clone MGC:97292 IMAGE:7262541), complete cds. BC069745 - Homo sapiens glycoprotein A33 (transmembrane), mRNA (cDNA clone MGC:97304 IMAGE:7262553), complete cds. BC069761 - Homo sapiens glycoprotein A33 (transmembrane), mRNA (cDNA clone MGC:97316 IMAGE:7262565), complete cds. BC069789 - Homo sapiens glycoprotein A33 (transmembrane), mRNA (cDNA clone MGC:97233 IMAGE:7262482), complete cds. JD138525 - Sequence 119549 from Patent EP1572962. JD270424 - Sequence 251448 from Patent EP1572962. BC107164 - Homo sapiens glycoprotein A33 (transmembrane), mRNA (cDNA clone MGC:129986 IMAGE:40034324), complete cds. BC107165 - Homo sapiens glycoprotein A33 (transmembrane), mRNA (cDNA clone MGC:129987 IMAGE:40034331), complete cds. JD320666 - Sequence 301690 from Patent EP1572962. JD273653 - Sequence 254677 from Patent EP1572962. JD202211 - Sequence 183235 from Patent EP1572962. JD108718 - Sequence 89742 from Patent EP1572962. JD484482 - Sequence 465506 from Patent EP1572962. JD544016 - Sequence 525040 from Patent EP1572962. JD160627 - Sequence 141651 from Patent EP1572962. JD121266 - Sequence 102290 from Patent EP1572962. JD278787 - Sequence 259811 from Patent EP1572962. JD189517 - Sequence 170541 from Patent EP1572962. JD269979 - Sequence 251003 from Patent EP1572962. JD541649 - Sequence 522673 from Patent EP1572962. JD156679 - Sequence 137703 from Patent EP1572962. JD370040 - Sequence 351064 from Patent EP1572962. JD158196 - Sequence 139220 from Patent EP1572962. JD220625 - Sequence 201649 from Patent EP1572962. JD415417 - Sequence 396441 from Patent EP1572962. JD151101 - Sequence 132125 from Patent EP1572962. JD142935 - Sequence 123959 from Patent EP1572962. JD319913 - Sequence 300937 from Patent EP1572962. JD412355 - Sequence 393379 from Patent EP1572962. JD477450 - Sequence 458474 from Patent EP1572962. JD393793 - Sequence 374817 from Patent EP1572962. BC074830 - Homo sapiens glycoprotein A33 (transmembrane), mRNA (cDNA clone MGC:104092 IMAGE:30915543), complete cds. BC074876 - Homo sapiens glycoprotein A33 (transmembrane), mRNA (cDNA clone MGC:103854 IMAGE:30915236), complete cds. JD209358 - Sequence 190382 from Patent EP1572962. JD453002 - Sequence 434026 from Patent EP1572962. JD137692 - Sequence 118716 from Patent EP1572962. AK312833 - Homo sapiens cDNA, FLJ93270, Homo sapiens glycoprotein A33 (transmembrane) (GPA33), mRNA. HQ447448 - Synthetic construct Homo sapiens clone IMAGE:100070776; CCSB013999_03 glycoprotein A33 (transmembrane) (GPA33) gene, encodes complete protein. KJ892966 - Synthetic construct Homo sapiens clone ccsbBroadEn_02360 GPA33 gene, encodes complete protein. CU687006 - Synthetic construct Homo sapiens gateway clone IMAGE:100022555 5' read GPA33 mRNA. JD435993 - Sequence 417017 from Patent EP1572962.
Sequence and Links to Tools and Databases 
Microarray Expression Data 
