Human Gene HSD11B1 (ENST00000367027.5) from GENCODE V50

Description: hydroxysteroid 11-beta dehydrogenase 1, transcript variant 1 (from RefSeq NM_005525.4)
Gencode Transcript: ENST00000367027.5
Gencode Gene: ENSG00000117594.12
Transcript (Including UTRs)
Position: hg38 chr1:209,704,846-209,734,929 Size: 30,084 Total Exon Count: 6 Strand: +
Coding Region
Position: hg38 chr1:209,704,943-209,734,521 Size: 29,579 Coding Exon Count: 6

Page Index	Sequence and Links	Primers	MalaCards	CTD	RNA-Seq Expression
Microarray Expression	RNA Structure	Other Species	mRNA Descriptions	Pathways	Other Names
Methods

Data last updated at UCSC: 2026-07-12 09:30:09

Sequence and Links to Tools and Databases

Genomic Sequence (chr1:209,704,846-209,734,929)			mRNA (may differ from genome)		Protein (292 aa)
Gene Sorter	Genome Browser	Other Species FASTA	Gene interactions	Table Schema	AlphaFold
BioGPS	Ensembl	Entrez Gene	ExonPrimer	Gencode	GeneCards
HGNC	Lynx	Malacards	MGI	OMIM	PubMed
UniProtKB	Wikipedia	BioGrid CRISPR DB

Primer design for this transcript

Primer3Plus can design qPCR Primers that straddle exon-exon-junctions, which amplify only cDNA, not genomic DNA.
Click here to load the transcript sequence and exon structure into Primer3Plus

Exonprimer can design one pair of Sanger sequencing primers around every exon, located in non-genic sequence.
Click here to open Exonprimer with this transcript

To design primers for a non-coding sequence, zoom to a region of interest and select from the drop-down menu: View > In External Tools > Primer3

MalaCards Disease Associations


	MalaCards Gene Search: HSD11B1 Diseases sorted by gene-association score: cortisone reductase deficiency 2* (1000), hyperandrogenism due to cortisone reductase deficiency* (350), cortisone reductase deficiency (52), apparent mineralocorticoid excess (12), polycystic ovary syndrome (11), abdominal obesity-metabolic syndrome 1 (11), cushing's syndrome (9), adrenal adenoma (8), van der woude syndrome (7), ocular hypertension (7), intracranial hypertension (6), acth deficiency (6), obesity (5), pituitary-dependent cushing's disease (3), diabetes mellitus, noninsulin-dependent (2), osteoporosis (2), overnutrition (1) * = Manually curated disease association

Comparative Toxicogenomics Database (CTD)


	The following chemicals interact with this gene D003907 Dexamethasone D001564 Benzo(a)pyrene D003345 Corticosterone D006854 Hydrocortisone D013749 Tetrachlorodibenzodioxin C023036 perfluorooctanoic acid C089730 rosiglitazone C404910 2,2-bis(4-hydroxyphenyl)-1,1,1-trichloroethane D002994 Clofibrate D003348 Cortisone more ... click here to view the complete list

RNA-Seq Expression Data from GTEx (53 Tissues, 570 Donors)


	Highest median expression: 150.80 RPKM in Liver Total median expression: 414.58 RPKM View in GTEx track of Genome Browser View at GTEx portal View GTEx Body Map

Microarray Expression Data

mRNA Secondary Structure of 3' and 5' UTRs

Region	Fold Energy	Bases	Energy/Base	Display As
5' UTR	-29.10	97	-0.300	Picture	PostScript	Text
3' UTR	-98.90	408	-0.242	Picture	PostScript	Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

Orthologous Genes in Other Species

Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.

Mouse	Rat	Zebrafish	D. melanogaster	C. elegans	S. cerevisiae
Genome Browser	Genome Browser	No ortholog	No ortholog	No ortholog	No ortholog
Gene Details
Gene Sorter
MGI	RGD
Protein Sequence	Protein Sequence
Alignment	Alignment

Descriptions from all associated GenBank mRNAs


	DD367262 - 11-beta-HSD1 antisense compounds. BC012593 - Homo sapiens hydroxysteroid (11-beta) dehydrogenase 1, mRNA (cDNA clone MGC:13539 IMAGE:4286028), complete cds. DD367248 - 11-beta-HSD1 antisense compounds. AK313973 - Homo sapiens cDNA, FLJ94621, Homo sapiens hydroxysteroid (11-beta) dehydrogenase 1 (HSD11B1), mRNA. KJ897009 - Synthetic construct Homo sapiens clone ccsbBroadEn_06403 HSD11B1 gene, encodes complete protein. AB590223 - Synthetic construct DNA, clone: pFN21AE1493, Homo sapiens HSD11B1 gene for hydroxysteroid (11-beta) dehydrogenase 1, without stop codon, in Flexi system. KJ534869 - Homo sapiens clone HSD11B1_iso-A_adult-A09 hydroxysteroid 11-beta dehydrogenase 1 isoform A (HSD11B1) mRNA, partial cds, alternatively spliced. DQ892912 - Synthetic construct clone IMAGE:100005542; FLH190768.01X; RZPDo839D1076D hydroxysteroid (11-beta) dehydrogenase 1 (HSD11B1) gene, encodes complete protein. EU176721 - Synthetic construct Homo sapiens clone IMAGE:100011642; FLH264001.01L; RZPDo839A10245D hydroxysteroid (11-beta) dehydrogenase 1 (HSD11B1) gene, encodes complete protein. JD162973 - Sequence 143997 from Patent EP1572962. JD184576 - Sequence 165600 from Patent EP1572962. JD198668 - Sequence 179692 from Patent EP1572962. JD377820 - Sequence 358844 from Patent EP1572962. JD417396 - Sequence 398420 from Patent EP1572962. JD503539 - Sequence 484563 from Patent EP1572962.

Biochemical and Signaling Pathways


	KEGG - Kyoto Encyclopedia of Genes and Genomes hsa00140 - Steroid hormone biosynthesis hsa01100 - Metabolic pathways hsa04960 - Aldosterone-regulated sodium reabsorption BioCyc Knowledge Library PWY-8202 - 11-oxyandrogens biosynthesis BioCarta from NCI Cancer Genome Anatomy Project h_vobesityPathway - Visceral Fat Deposits and the Metabolic Syndrome

Other Names for This Gene


	Alternate Gene Symbols: ENST00000367027.1, ENST00000367027.2, ENST00000367027.3, ENST00000367027.4, HSD11B1 , NM_005525, uc001hhk.1, uc001hhk.2, uc001hhk.3, uc001hhk.4, uc001hhk.5, X5D2L1, X5D2L1_HUMAN UCSC ID: ENST00000367027.5 RefSeq Accession: NM_005525.4 CCDS: CCDS1489.1

Methods, Credits, and Use Restrictions


	Click here for details on how this gene model was made and data restrictions if any.

GNF Expression Atlas 2 Data from U133A and GNF1H Chips