Description: Homo sapiens islet amyloid polypeptide (IAPP), transcript variant 2, mRNA. (from RefSeq NM_001329201) RefSeq Summary (NM_001329201): This gene encodes a member of the calcitonin family of peptide hormones. This hormone is released from pancreatic beta cells following food intake to regulate blood glucose levels and act as a satiation signal. Human patients with type 1 and advanced type 2 diabetes exhibit reduced levels of the encoded hormone in blood and pancreas. This protein also exhibits a bactericidal, antimicrobial activity. [provided by RefSeq, Jul 2016]. Gencode Transcript: ENST00000539393.5 Gencode Gene: ENSG00000121351.8 Transcript (Including UTRs) Position: hg38 chr12:21,354,959-21,378,495 Size: 23,537 Total Exon Count: 3 Strand: + Coding Region Position: hg38 chr12:21,373,352-21,378,426 Size: 5,075 Coding Exon Count: 2
ID:IAPP_HUMAN DESCRIPTION: RecName: Full=Islet amyloid polypeptide; AltName: Full=Amylin; AltName: Full=Diabetes-associated peptide; Short=DAP; AltName: Full=Insulinoma amyloid peptide; Flags: Precursor; FUNCTION: Selectively inhibits insulin-stimulated glucose utilization and glycogen deposition in muscle, while not affecting adipocyte glucose metabolism. SUBUNIT: Interacts with IDE and INS. Can form homodimers. Interaction with INS inhibits homodimerization and fibril formation. SUBCELLULAR LOCATION: Secreted. DOMAIN: The mature protein is largely unstructured in the absence of a cognate ligand, and has a strong tendency to form fibrillar aggregates. Homodimerization may be the first step of amyloid formation. PTM: Amyloid fibrils are degraded by IDE. MASS SPECTROMETRY: Mass=3936; Method=MALDI; Range=34-70; Source=PubMed:17374526; MISCELLANEOUS: IAPP is the peptide subunit of amyloid found in pancreatic islets of type 2 diabetic patients and in insulinomas. SIMILARITY: Belongs to the calcitonin family. WEB RESOURCE: Name=Wikipedia; Note=Amylin entry; URL="http://en.wikipedia.org/wiki/Amylin";
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
ModBase Predicted Comparative 3D Structure on P10997
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.