Human Gene ITGAX (ENST00000268296.9)
  Description: Homo sapiens integrin subunit alpha X (ITGAX), transcript variant 2, mRNA. (from RefSeq NM_000887)
RefSeq Summary (NM_000887): This gene encodes the integrin alpha X chain protein. Integrins are heterodimeric integral membrane proteins composed of an alpha chain and a beta chain. This protein combines with the beta 2 chain (ITGB2) to form a leukocyte-specific integrin referred to as inactivated-C3b (iC3b) receptor 4 (CR4). The alpha X beta 2 complex seems to overlap the properties of the alpha M beta 2 integrin in the adherence of neutrophils and monocytes to stimulated endothelium cells, and in the phagocytosis of complement coated particles. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Nov 2013].
Gencode Transcript: ENST00000268296.9
Gencode Gene: ENSG00000140678.17
Transcript (Including UTRs)
   Position: hg38 chr16:31,355,176-31,382,999 Size: 27,824 Total Exon Count: 30 Strand: +
Coding Region
   Position: hg38 chr16:31,355,255-31,381,907 Size: 26,653 Coding Exon Count: 30 

Page IndexSequence and LinksUniProtKB CommentsMalaCardsCTDRNA-Seq Expression
Microarray ExpressionRNA StructureProtein StructureOther SpeciesGO AnnotationsmRNA Descriptions
PathwaysOther NamesMethods
Data last updated at UCSC: 2021-01-14 15:32:12

-  Sequence and Links to Tools and Databases
 
Genomic Sequence (chr16:31,355,176-31,382,999)mRNA (may differ from genome)Protein (1163 aa)
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HPRDLynxMGIneXtProtOMIMPubMed
ReactomeUniProtKBWikipedia

-  Comments and Description Text from UniProtKB
  ID: ITAX_HUMAN
DESCRIPTION: RecName: Full=Integrin alpha-X; AltName: Full=CD11 antigen-like family member C; AltName: Full=Leu M5; AltName: Full=Leukocyte adhesion glycoprotein p150,95 alpha chain; AltName: Full=Leukocyte adhesion receptor p150,95; AltName: CD_antigen=CD11c; Flags: Precursor;
FUNCTION: Integrin alpha-X/beta-2 is a receptor for fibrinogen. It recognizes the sequence G-P-R in fibrinogen. It mediates cell-cell interaction during inflammatory responses. It is especially important in monocyte adhesion and chemotaxis.
SUBUNIT: Heterodimer of an alpha and a beta subunit. Alpha-X associates with beta-2.
SUBCELLULAR LOCATION: Membrane; Single-pass type I membrane protein.
TISSUE SPECIFICITY: Predominantly expressed in monocytes and granulocytes.
DOMAIN: The integrin I-domain (insert) is a VWFA domain. Integrins with I-domains do not undergo protease cleavage.
SIMILARITY: Belongs to the integrin alpha chain family.
SIMILARITY: Contains 7 FG-GAP repeats.
SIMILARITY: Contains 1 VWFA domain.

-  MalaCards Disease Associations
  MalaCards Gene Search: ITGAX
Diseases sorted by gene-association score: hairy cell leukemia (9), benign cephalic histiocytosis (6), histiocytosis (3), lymphocytic vasculitis (3), mantle cell lymphoma (2), bladder lymphoma (1), chronic monocytic leukemia (1), non-secretory myeloma (1), diffuse infiltrative lymphocytosis syndrome (1), lymphoma, non-hodgkin (1), xanthogranulomatous pyelonephritis (1), leukemia, acute myeloid (0)

-  Comparative Toxicogenomics Database (CTD)
  The following chemicals interact with this gene           more ... click here to view the complete list

-  RNA-Seq Expression Data from GTEx (53 Tissues, 570 Donors)
  Highest median expression: 176.46 RPKM in Whole Blood
Total median expression: 404.79 RPKM



View in GTEx track of Genome Browser    View at GTEx portal     View GTEx Body Map

+  Microarray Expression Data
  Press "+" in the title bar above to open this section.

-  mRNA Secondary Structure of 3' and 5' UTRs
 
RegionFold EnergyBasesEnergy/Base
Display As
5' UTR -17.5079-0.222 Picture PostScript Text
3' UTR -360.501092-0.330 Picture PostScript Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

-  Protein Domain and Structure Information
  InterPro Domains: Graphical view of domain structure
IPR013517 - FG-GAP
IPR013519 - Int_alpha_beta-p
IPR000413 - Integrin_alpha
IPR013649 - Integrin_alpha-2
IPR018184 - Integrin_alpha_C_CS
IPR002035 - VWF_A

Pfam Domains:
PF01839 - FG-GAP repeat
PF00357 - Integrin alpha cytoplasmic region
PF08441 - Integrin alpha
PF00092 - von Willebrand factor type A domain

Protein Data Bank (PDB) 3-D Structure
MuPIT help

1N3Y
- X-ray MuPIT

2LUV
- NMR

3K6S
- X-ray MuPIT
To conserve bandwidth, only the images from the first 3 structures are shown.
3K71 - X-ray MuPIT 3K72 - X-ray MuPIT


ModBase Predicted Comparative 3D Structure on P20702
FrontTopSide
The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.

-  Orthologous Genes in Other Species
  Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
MouseRatZebrafishD. melanogasterC. elegansS. cerevisiae
Genome BrowserGenome BrowserNo orthologNo orthologNo orthologNo ortholog
Gene Details     
Gene Sorter     
MGIRGDEnsembl   
Protein SequenceProtein Sequence    
AlignmentAlignment    

-  Gene Ontology (GO) Annotations with Structured Vocabulary
  Molecular Function:
GO:0005515 protein binding
GO:0038023 signaling receptor activity
GO:0046872 metal ion binding

Biological Process:
GO:0007155 cell adhesion
GO:0007229 integrin-mediated signaling pathway
GO:0009887 animal organ morphogenesis
GO:0019221 cytokine-mediated signaling pathway
GO:0030198 extracellular matrix organization
GO:0034113 heterotypic cell-cell adhesion
GO:0043312 neutrophil degranulation
GO:0050900 leukocyte migration

Cellular Component:
GO:0005886 plasma membrane
GO:0008305 integrin complex
GO:0009986 cell surface
GO:0016020 membrane
GO:0016021 integral component of membrane
GO:0030667 secretory granule membrane
GO:0070821 tertiary granule membrane
GO:0101003 ficolin-1-rich granule membrane


-  Descriptions from all associated GenBank mRNAs
  AK296666 - Homo sapiens cDNA FLJ59919 complete cds, highly similar to Integrin alpha-X precursor.
AK309642 - Homo sapiens cDNA, FLJ99683.
M81695 - Homo sapiens eukocyte adhesion glycoprotein precursor (ITGAX) mRNA, complete cds.
JD185184 - Sequence 166208 from Patent EP1572962.
BC037577 - Homo sapiens integrin, alpha X (complement component 3 receptor 4 subunit), mRNA (cDNA clone IMAGE:5757182), with apparent retained intron.
BC038237 - Homo sapiens integrin, alpha X (complement component 3 receptor 4 subunit), mRNA (cDNA clone MGC:46124 IMAGE:5745308), complete cds.
JD248262 - Sequence 229286 from Patent EP1572962.
DQ892486 - Synthetic construct clone IMAGE:100005116; FLH186745.01X; RZPDo839H1171D integrin, alpha X (complement component 3 receptor 4 subunit) (ITGAX) gene, encodes complete protein.
DQ895697 - Synthetic construct Homo sapiens clone IMAGE:100010157; FLH186744.01L; RZPDo839H1161D integrin, alpha X (complement component 3 receptor 4 subunit) (ITGAX) gene, encodes complete protein.
AK074047 - Homo sapiens mRNA for FLJ00114 protein.
AK293367 - Homo sapiens cDNA FLJ59843 complete cds, highly similar to Integrin alpha-X precursor.
JD052976 - Sequence 34000 from Patent EP1572962.
JD377101 - Sequence 358125 from Patent EP1572962.
JD287313 - Sequence 268337 from Patent EP1572962.
JD495712 - Sequence 476736 from Patent EP1572962.
JD444978 - Sequence 426002 from Patent EP1572962.
JD356014 - Sequence 337038 from Patent EP1572962.
JD055930 - Sequence 36954 from Patent EP1572962.
JD123867 - Sequence 104891 from Patent EP1572962.
JD321935 - Sequence 302959 from Patent EP1572962.
JD489178 - Sequence 470202 from Patent EP1572962.
JD071924 - Sequence 52948 from Patent EP1572962.
JD079731 - Sequence 60755 from Patent EP1572962.
JD190990 - Sequence 172014 from Patent EP1572962.
JD409948 - Sequence 390972 from Patent EP1572962.
JD468019 - Sequence 449043 from Patent EP1572962.
JD520261 - Sequence 501285 from Patent EP1572962.
JD354759 - Sequence 335783 from Patent EP1572962.
JD559487 - Sequence 540511 from Patent EP1572962.
JD104468 - Sequence 85492 from Patent EP1572962.

-  Biochemical and Signaling Pathways
  KEGG - Kyoto Encyclopedia of Genes and Genomes
hsa04810 - Regulation of actin cytoskeleton

BioCarta from NCI Cancer Genome Anatomy Project
h_dcPathway - Dendritic cells in regulating TH1 and TH2 Development

Reactome (by CSHL, EBI, and GO)

Protein P20702 (Reactome details) participates in the following event(s):

R-HSA-202704 Integrin alphaXbeta2 binds JAM3
R-HSA-216082 Interaction of integrin alphaXbeta2 with fibrin
R-HSA-6798747 Exocytosis of tertiary granule membrane proteins
R-HSA-6800426 Exocytosis of ficolin-rich granule membrane proteins
R-HSA-6798743 Exocytosis of secretory granule membrane proteins
R-HSA-2681667 TNC binds Integrin alphaVbeta3, alphaVbeta6, alpha2beta1, alpha7beta1, alpha8beta1, alpha9beta1, alphaXbeta1
R-HSA-202733 Cell surface interactions at the vascular wall
R-HSA-216083 Integrin cell surface interactions
R-HSA-6785807 Interleukin-4 and 13 signaling
R-HSA-6798695 Neutrophil degranulation
R-HSA-109582 Hemostasis
R-HSA-1474244 Extracellular matrix organization
R-HSA-3000178 ECM proteoglycans
R-HSA-449147 Signaling by Interleukins
R-HSA-168249 Innate Immune System
R-HSA-1280215 Cytokine Signaling in Immune system
R-HSA-168256 Immune System

-  Other Names for This Gene
  Alternate Gene Symbols: CD11C, ENST00000268296.1, ENST00000268296.2, ENST00000268296.3, ENST00000268296.4, ENST00000268296.5, ENST00000268296.6, ENST00000268296.7, ENST00000268296.8, ITAX_HUMAN, NM_000887, P20702, Q8IVA6, uc002ebu.1, uc002ebu.2, uc002ebu.3
UCSC ID: ENST00000268296.9
RefSeq Accession: NM_000887
Protein: P20702 (aka ITAX_HUMAN)
CCDS: CCDS10711.1, CCDS67014.1

-  Methods, Credits, and Use Restrictions
  Click here for details on how this gene model was made and data restrictions if any.