Human Gene NPPB (ENST00000376468.4) Description and Page Index
Description: Homo sapiens natriuretic peptide B (NPPB), mRNA. (from RefSeq NM_002521) RefSeq Summary (NM_002521): This gene is a member of the natriuretic peptide family and encodes a secreted protein which functions as a cardiac hormone. The protein undergoes two cleavage events, one within the cell and a second after secretion into the blood. The protein's biological actions include natriuresis, diuresis, vasorelaxation, inhibition of renin and aldosterone secretion, and a key role in cardiovascular homeostasis. A high concentration of this protein in the bloodstream is indicative of heart failure. The protein also acts as an antimicrobial peptide with antibacterial and antifungal activity. Mutations in this gene have been associated with postmenopausal osteoporosis. [provided by RefSeq, Nov 2014]. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: BC025785.1, SRR5189655.214911.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA2148093, SAMEA2151741 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## MANE Ensembl match :: ENST00000376468.4/ ENSP00000365651.3 Protein has antimicrobial activity :: PMID: 11410403 RefSeq Select criteria :: based on single protein-coding transcript ##RefSeq-Attributes-END## Gencode Transcript: ENST00000376468.4 Gencode Gene: ENSG00000120937.9 Transcript (Including UTRs) Position: hg38 chr1:11,857,464-11,858,945 Size: 1,482 Total Exon Count: 3 Strand: - Coding Region Position: hg38 chr1:11,857,655-11,858,833 Size: 1,179 Coding Exon Count: 3
ID:ANFB_HUMAN DESCRIPTION: RecName: Full=Natriuretic peptides B; AltName: Full=Gamma-brain natriuretic peptide; Contains: RecName: Full=Brain natriuretic peptide 32; Short=BNP(1-32); Short=BNP-32; Contains: RecName: Full=BNP(1-30); Contains: RecName: Full=BNP(1-29); Contains: RecName: Full=BNP(1-28); Contains: RecName: Full=BNP(2-31); Contains: RecName: Full=BNP(3-32); Contains: RecName: Full=BNP(3-30); Contains: RecName: Full=BNP(3-29); Contains: RecName: Full=BNP(4-32); Contains: RecName: Full=BNP(4-31); Contains: RecName: Full=BNP(4-30); Contains: RecName: Full=BNP(4-29); Contains: RecName: Full=BNP(4-27); Contains: RecName: Full=BNP(5-32); Contains: RecName: Full=BNP(5-31); Contains: RecName: Full=BNP(5-29); Flags: Precursor; FUNCTION: Cardiac hormone which may function as a paracrine antifibrotic factor in the heart. Also plays a key role in cardiovascular homeostasis through natriuresis, diuresis, vasorelaxation, and inhibition of renin and aldosterone secretion. Specifically binds and stimulates the cGMP production of the NPR1 receptor. Binds the clearance receptor NPR3. SUBCELLULAR LOCATION: Secreted. TISSUE SPECIFICITY: Brain and also in atria, but at much lower levels than ANP. PHARMACEUTICAL: Available under the name Nesiritide (Scios). Used for the treatment of heart failure. SIMILARITY: Belongs to the natriuretic peptide family. SEQUENCE CAUTION: Sequence=BAA90441.1; Type=Frameshift; Positions=44; WEB RESOURCE: Name=Wikipedia; Note=Brain natriuretic peptide entry; URL="http://en.wikipedia.org/wiki/Brain_natriuretic_peptide";
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
ModBase Predicted Comparative 3D Structure on P16860
The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.
Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.