Human Gene OLIG2 (ENST00000333337.3) Description and Page Index
Description: Required for oligodendrocyte and motor neuron specification in the spinal cord, as well as for the development of somatic motor neurons in the hindbrain. Cooperates with OLIG1 to establish the pMN domain of the embryonic neural tube. Antagonist of V2 interneuron and of NKX2-2-induced V3 interneuron development (By similarity). (from UniProt Q13516) Gencode Transcript: ENST00000333337.3 Gencode Gene: ENSG00000205927.5 Transcript (Including UTRs) Position: hg38 chr21:33,025,935-33,029,196 Size: 3,262 Total Exon Count: 1 Strand: + Coding Region Position: hg38 chr21:33,026,863-33,027,834 Size: 972 Coding Exon Count: 1
ID:OLIG2_HUMAN DESCRIPTION: RecName: Full=Oligodendrocyte transcription factor 2; Short=Oligo2; AltName: Full=Class B basic helix-loop-helix protein 1; Short=bHLHb1; AltName: Full=Class E basic helix-loop-helix protein 19; Short=bHLHe19; AltName: Full=Protein kinase C-binding protein 2; AltName: Full=Protein kinase C-binding protein RACK17; FUNCTION: Required for oligodendrocyte and motor neuron specification in the spinal cord, as well as for the development of somatic motor neurons in the hindbrain. Cooperates with OLIG1 to establish the pMN domain of the embryonic neural tube. Antagonist of V2 interneuron and of NKX2-2-induced V3 interneuron development (By similarity). SUBUNIT: Interacts with NKX2-2 (By similarity). SUBCELLULAR LOCATION: Nucleus (By similarity). Cytoplasm (By similarity). Note=The NLS contained in the bHLH domain could be masked in the native form and translocation to the nucleus could be mediated by interaction either with class E bHLH partner protein or with NKX2-2 (By similarity). TISSUE SPECIFICITY: Expressed in the brain, in oligodendrocytes. Strongly expressed in oligodendrogliomas, while expression is weak to moderate in astrocytomas. Expression in glioblastomas highly variable. INDUCTION: By SHH. Also induced by NKX6-1 in the developing spinal cord, but not in the rostral hindbrain (By similarity). DOMAIN: The bHLH is essential for interaction with NKX2-2 (By similarity). DISEASE: Note=A chromosomal aberration involving OLIG2 may be a cause of a form of T-cell acute lymphoblastic leukemia (T-ALL). Translocation t(14;21)(q11.2;q22) with TCRA. SIMILARITY: Contains 1 bHLH (basic helix-loop-helix) domain. SEQUENCE CAUTION: Sequence=AAC72247.1; Type=Erroneous initiation; Sequence=AAF61215.1; Type=Erroneous initiation; WEB RESOURCE: Name=Atlas of Genetics and Cytogenetics in Oncology and Haematology; URL="http://atlasgeneticsoncology.org/Genes/OLIG2ID236.html";
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
ModBase Predicted Comparative 3D Structure on Q13516
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.