Human Gene PIEZO2 (ENST00000674853.1) from GENCODE V50

Description: piezo type mechanosensitive ion channel component 2, transcript variant 1 (from RefSeq NM_001378183.1)
Gencode Transcript: ENST00000674853.1
Gencode Gene: ENSG00000154864.15
Transcript (Including UTRs)
Position: hg38 chr18:10,670,247-11,149,569 Size: 479,323 Total Exon Count: 56 Strand: -
Coding Region
Position: hg38 chr18:10,671,527-11,148,588 Size: 477,062 Coding Exon Count: 56

Page Index	Sequence and Links	Primers	MalaCards	CTD	RNA-Seq Expression
Microarray Expression	RNA Structure	Other Species	mRNA Descriptions	Other Names	Methods

Data last updated at UCSC: 2026-07-12 09:30:09

Sequence and Links to Tools and Databases

Genomic Sequence (chr18:10,670,247-11,149,569)			mRNA (may differ from genome)		Protein (2865 aa)
Gene Sorter	Genome Browser	Other Species FASTA	Gene interactions	Table Schema	AlphaFold
BioGPS	Ensembl	Entrez Gene	ExonPrimer	Gencode	GeneCards
HGNC	Lynx	Malacards	MGI	myGene2	OMIM
PubMed	UniProtKB	Wikipedia	BioGrid CRISPR DB

Primer design for this transcript

Primer3Plus can design qPCR Primers that straddle exon-exon-junctions, which amplify only cDNA, not genomic DNA.
Click here to load the transcript sequence and exon structure into Primer3Plus

Exonprimer can design one pair of Sanger sequencing primers around every exon, located in non-genic sequence.
Click here to open Exonprimer with this transcript

To design primers for a non-coding sequence, zoom to a region of interest and select from the drop-down menu: View > In External Tools > Primer3

MalaCards Disease Associations


	MalaCards Gene Search: PIEZO2 Diseases sorted by gene-association score: marden-walker syndrome* (1739), arthrogryposis, distal, type 3* (1650), arthrogryposis, distal, type 5* (1550), arthrogryposis, distal, with impaired proprioception and touch* (1230), arthrogryposis multiple congenita, ophthalmoplegia, ptosis* (400), pseudohypoaldosteronism, type iie* (283), distal arthrogryposis* (200) * = Manually curated disease association

Comparative Toxicogenomics Database (CTD)


	The following chemicals interact with this gene D001564 Benzo(a)pyrene D013749 Tetrachlorodibenzodioxin D016604 Aflatoxin B1 D000393 Air Pollutants D019327 Copper Sulfate D016572 Cyclosporine D004997 Ethinyl Estradiol D058185 Magnetite Nanoparticles D011794 Quercetin D004113 Succimer more ... click here to view the complete list

RNA-Seq Expression Data from GTEx (53 Tissues, 570 Donors)


	Highest median expression: 3.37 RPKM in Brain - Spinal cord (cervical c-1) Total median expression: 30.89 RPKM View in GTEx track of Genome Browser View at GTEx portal View GTEx Body Map

Microarray Expression Data

mRNA Secondary Structure of 3' and 5' UTRs

Region	Fold Energy	Bases	Energy/Base	Display As
5' UTR	-522.50	981	-0.533	Picture	PostScript	Text
3' UTR	-318.70	1280	-0.249	Picture	PostScript	Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

Orthologous Genes in Other Species

Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.

Mouse	Rat	Zebrafish	D. melanogaster	C. elegans	S. cerevisiae
Genome Browser	Genome Browser	Genome Browser	Genome Browser	No ortholog	No ortholog
Gene Details
Gene Sorter
MGI	RGD	Ensembl	Ensembl
Protein Sequence	Protein Sequence	Protein Sequence	Protein Sequence
Alignment	Alignment	Alignment	Alignment

Descriptions from all associated GenBank mRNAs


	JN790819 - Homo sapiens PIEZO2 (PIEZO2) mRNA, complete cds. MG254547 - Homo sapiens PIEZO2 variant 16 (PIEZO2) mRNA, complete cds, alternatively spliced. AK127627 - Homo sapiens cDNA FLJ45725 fis, clone HCHON2009766. AK095053 - Homo sapiens cDNA FLJ37734 fis, clone BRHIP2020842. AK092226 - Homo sapiens cDNA FLJ34907 fis, clone NT2RI2003392. AX747416 - Sequence 941 from Patent EP1308459. AK026797 - Homo sapiens cDNA: FLJ23144 fis, clone LNG09262. AK027056 - Homo sapiens cDNA: FLJ23403 fis, clone HEP18857. JD422964 - Sequence 403988 from Patent EP1572962. JD084586 - Sequence 65610 from Patent EP1572962. AK302764 - Homo sapiens cDNA FLJ55399 complete cds, highly similar to Protein FAM38B. JD164871 - Sequence 145895 from Patent EP1572962. JD315133 - Sequence 296157 from Patent EP1572962. BC148379 - Synthetic construct Homo sapiens clone IMAGE:100015296, MGC:182972 family with sequence similarity 38, member B (FAM38B) mRNA, encodes complete protein. AB527139 - Synthetic construct DNA, clone: pF1KE0043, Homo sapiens FAM38B gene for family with sequence similarity 38, member B, without stop codon, in Flexi system. JD160185 - Sequence 141209 from Patent EP1572962. JD327823 - Sequence 308847 from Patent EP1572962. AK098782 - Homo sapiens cDNA FLJ25916 fis, clone CBR04903. JD110976 - Sequence 92000 from Patent EP1572962. JD347797 - Sequence 328821 from Patent EP1572962. JD039114 - Sequence 20138 from Patent EP1572962. JD528285 - Sequence 509309 from Patent EP1572962.

Other Names for This Gene


	Alternate Gene Symbols: A0A2H4UKA7, A0A2H4UKA7_HUMAN, NM_001378183, PIEZO2 , uc288nyw.1 UCSC ID: ENST00000674853.1 RefSeq Accession: NM_001378183.1 CCDS: CCDS11850.2

Methods, Credits, and Use Restrictions


	Click here for details on how this gene model was made and data restrictions if any.

GNF Expression Atlas 2 Data from U133A and GNF1H Chips