Human Gene PVR (ENST00000425690.8) Description and Page Index
  Description: Homo sapiens PVR cell adhesion molecule (PVR), transcript variant 1, mRNA. (from RefSeq NM_006505)
RefSeq Summary (NM_006505): The protein encoded by this gene is a transmembrane glycoprotein belonging to the immunoglobulin superfamily. The external domain mediates cell attachment to the extracellular matrix molecule vitronectin, while its intracellular domain interacts with the dynein light chain Tctex-1/DYNLT1. The gene is specific to the primate lineage, and serves as a cellular receptor for poliovirus in the first step of poliovirus replication. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Oct 2008].
Gencode Transcript: ENST00000425690.8
Gencode Gene: ENSG00000073008.15
Transcript (Including UTRs)
   Position: hg38 chr19:44,643,910-44,666,162 Size: 22,253 Total Exon Count: 8 Strand: +
Coding Region
   Position: hg38 chr19:44,644,097-44,661,811 Size: 17,715 Coding Exon Count: 8 

Page IndexSequence and LinksMalaCardsCTDRNA-Seq ExpressionMicroarray Expression
RNA StructureOther SpeciesmRNA DescriptionsPathwaysOther NamesMethods
Data last updated: 2019-09-04

-  Sequence and Links to Tools and Databases
 
Genomic Sequence (chr19:44,643,910-44,666,162)mRNA (may differ from genome)Protein (417 aa)
Gene SorterGenome BrowserOther Species FASTAGene interactionsTable SchemaBioGPS
CGAPEnsemblEntrez GeneExonPrimerGeneCardsHGNC
HPRDLynxMGIOMIMPubMedStanford SOURCE
UniProtKBWikipedia

-  MalaCards Disease Associations
  MalaCards Gene Search: PVR
Diseases sorted by gene-association score: poliomyelitis (35), paralytic poliomyelitis (25), heart conduction disease (20), pericardium disease (12), basilar artery insufficiency (11), cardiac tamponade (8), enterocele (8), prolapse of female genital organ (7), ovarian cystic teratoma (6), congenital bile acid synthesis defect (6), andersen syndrome (6), cleft lip/palate-ectodermal dysplasia syndrome (6), urethral diverticulum (5), pericardial effusion (4)

-  Comparative Toxicogenomics Database (CTD)
  The following chemicals interact with this gene
  • D013749 Tetrachlorodibenzodioxin
  • C006253 pirinixic acid
  • D015058 1-Naphthylisothiocyanate
  • C111118 2',3,3',4',5-pentachloro-4-hydroxybiphenyl
  • C010914 2,4-diaminotoluene
  • C016403 2,4-dinitrotoluene
  • C023514 2,6-dinitrotoluene
  • C009505 4,4'-diaminodiphenylmethane
  • C035207 4-amino-2,6-dinitrotoluene
  • D015123 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide
          more ... click here to view the complete list

-  RNA-Seq Expression Data from GTEx (53 Tissues, 570 Donors)
  Highest median expression: 11.36 RPKM in Cells - Transformed fibroblasts
Total median expression: 248.61 RPKM



View in GTEx track of Genome Browser    View at GTEx portal     View GTEx Body Map

+  Microarray Expression Data
  Press "+" in the title bar above to open this section.

-  mRNA Secondary Structure of 3' and 5' UTRs
 
RegionFold EnergyBasesEnergy/Base
Display As
5' UTR -82.40187-0.441 Picture PostScript Text
3' UTR -1597.904351-0.367 Picture PostScript Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

-  Orthologous Genes in Other Species
  Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
MouseRatZebrafishD. melanogasterC. elegansS. cerevisiae
No orthologNo orthologNo orthologNo orthologNo orthologNo ortholog
      
      
      
      
      

-  Descriptions from all associated GenBank mRNAs
  AK290946 - Homo sapiens cDNA FLJ75404 complete cds.
AK300349 - Homo sapiens cDNA FLJ58325 complete cds, highly similar to Poliovirus receptor precursor.
AK094177 - Homo sapiens cDNA FLJ36858 fis, clone ASTRO2015185, highly similar to POLIOVIRUS RECEPTOR PRECURSOR.
BC015542 - Homo sapiens poliovirus receptor, mRNA (cDNA clone MGC:9603 IMAGE:3902226), complete cds.
JD158099 - Sequence 139123 from Patent EP1572962.
CU677345 - Synthetic construct Homo sapiens gateway clone IMAGE:100019299 5' read PVR mRNA.
KJ897430 - Synthetic construct Homo sapiens clone ccsbBroadEn_06824 PVR gene, encodes complete protein.
DQ890969 - Synthetic construct clone IMAGE:100003599; FLH168103.01X; RZPDo839C0392D poliovirus receptor (PVR) gene, encodes complete protein.
DQ894143 - Synthetic construct Homo sapiens clone IMAGE:100008603; FLH168099.01L; RZPDo839C0391D poliovirus receptor (PVR) gene, encodes complete protein.
M24406 - Human poliovirus receptor mRNA, clone H20B.
M24407 - Human poliovirus receptor mRNA, clone H20A.
JD420887 - Sequence 401911 from Patent EP1572962.
JD531325 - Sequence 512349 from Patent EP1572962.
JD175302 - Sequence 156326 from Patent EP1572962.
JD483425 - Sequence 464449 from Patent EP1572962.
JD565193 - Sequence 546217 from Patent EP1572962.
AK025949 - Homo sapiens cDNA: FLJ22296 fis, clone HRC04468.
JD377813 - Sequence 358837 from Patent EP1572962.
JD548601 - Sequence 529625 from Patent EP1572962.
JD441216 - Sequence 422240 from Patent EP1572962.
JD550509 - Sequence 531533 from Patent EP1572962.
JD292711 - Sequence 273735 from Patent EP1572962.
JD511310 - Sequence 492334 from Patent EP1572962.
JD405047 - Sequence 386071 from Patent EP1572962.
JD070432 - Sequence 51456 from Patent EP1572962.
JD398635 - Sequence 379659 from Patent EP1572962.
JD337372 - Sequence 318396 from Patent EP1572962.
JD281922 - Sequence 262946 from Patent EP1572962.
JD304035 - Sequence 285059 from Patent EP1572962.
JD447404 - Sequence 428428 from Patent EP1572962.
JD262168 - Sequence 243192 from Patent EP1572962.
JD353346 - Sequence 334370 from Patent EP1572962.
JD059235 - Sequence 40259 from Patent EP1572962.
JD075863 - Sequence 56887 from Patent EP1572962.
JD205465 - Sequence 186489 from Patent EP1572962.
JD307749 - Sequence 288773 from Patent EP1572962.
JD371117 - Sequence 352141 from Patent EP1572962.
JD381900 - Sequence 362924 from Patent EP1572962.
JD383227 - Sequence 364251 from Patent EP1572962.
JD371118 - Sequence 352142 from Patent EP1572962.
JD450646 - Sequence 431670 from Patent EP1572962.
JD271486 - Sequence 252510 from Patent EP1572962.
JD428703 - Sequence 409727 from Patent EP1572962.
JD501258 - Sequence 482282 from Patent EP1572962.
JD440426 - Sequence 421450 from Patent EP1572962.
JD316981 - Sequence 298005 from Patent EP1572962.
JD074304 - Sequence 55328 from Patent EP1572962.
JD069359 - Sequence 50383 from Patent EP1572962.
JD459020 - Sequence 440044 from Patent EP1572962.
JD407978 - Sequence 389002 from Patent EP1572962.
JD203199 - Sequence 184223 from Patent EP1572962.
JD347588 - Sequence 328612 from Patent EP1572962.
JD283059 - Sequence 264083 from Patent EP1572962.
JD182179 - Sequence 163203 from Patent EP1572962.
JD236313 - Sequence 217337 from Patent EP1572962.
AK098812 - Homo sapiens cDNA FLJ25946 fis, clone JTH14258.
JD542286 - Sequence 523310 from Patent EP1572962.
JD478708 - Sequence 459732 from Patent EP1572962.
JD292706 - Sequence 273730 from Patent EP1572962.
JD466471 - Sequence 447495 from Patent EP1572962.
JD465004 - Sequence 446028 from Patent EP1572962.
JD116351 - Sequence 97375 from Patent EP1572962.
JD175523 - Sequence 156547 from Patent EP1572962.
JD255850 - Sequence 236874 from Patent EP1572962.
JD560659 - Sequence 541683 from Patent EP1572962.
JD310540 - Sequence 291564 from Patent EP1572962.
JD504920 - Sequence 485944 from Patent EP1572962.
JD503958 - Sequence 484982 from Patent EP1572962.
JD074073 - Sequence 55097 from Patent EP1572962.
JD270078 - Sequence 251102 from Patent EP1572962.
JD388981 - Sequence 370005 from Patent EP1572962.
JD108098 - Sequence 89122 from Patent EP1572962.
JD398318 - Sequence 379342 from Patent EP1572962.
JD150095 - Sequence 131119 from Patent EP1572962.
JD189501 - Sequence 170525 from Patent EP1572962.
JD097914 - Sequence 78938 from Patent EP1572962.
JD493622 - Sequence 474646 from Patent EP1572962.
JD494257 - Sequence 475281 from Patent EP1572962.
JD535589 - Sequence 516613 from Patent EP1572962.
JD382222 - Sequence 363246 from Patent EP1572962.
JD221930 - Sequence 202954 from Patent EP1572962.
JD229846 - Sequence 210870 from Patent EP1572962.
JD248021 - Sequence 229045 from Patent EP1572962.
JD215550 - Sequence 196574 from Patent EP1572962.
JD430281 - Sequence 411305 from Patent EP1572962.
JD125520 - Sequence 106544 from Patent EP1572962.
JD377640 - Sequence 358664 from Patent EP1572962.
JD088642 - Sequence 69666 from Patent EP1572962.
JD267566 - Sequence 248590 from Patent EP1572962.
JD448145 - Sequence 429169 from Patent EP1572962.
JD351513 - Sequence 332537 from Patent EP1572962.
JD347902 - Sequence 328926 from Patent EP1572962.
JD155924 - Sequence 136948 from Patent EP1572962.
JD292587 - Sequence 273611 from Patent EP1572962.
JD534855 - Sequence 515879 from Patent EP1572962.
JD366623 - Sequence 347647 from Patent EP1572962.
JD366624 - Sequence 347648 from Patent EP1572962.
JD517828 - Sequence 498852 from Patent EP1572962.
JD130556 - Sequence 111580 from Patent EP1572962.
JD161982 - Sequence 143006 from Patent EP1572962.

-  Biochemical and Signaling Pathways
  KEGG - Kyoto Encyclopedia of Genes and Genomes
hsa04514 - Cell adhesion molecules (CAMs)

-  Other Names for This Gene
  Alternate Gene Symbols: A0A0C4DG49, NM_006505, uc032hzv.1, uc032hzv.2, uc032hzv.3
UCSC ID: uc032hzv.3
RefSeq Accession: NM_006505
CCDS: CCDS12640.1

-  Methods, Credits, and Use Restrictions
  Click here for details on how this gene model was made and data restrictions if any.