Human Gene RGL1 (ENST00000360851.4) from GENCODE V50

Description: ral guanine nucleotide dissociation stimulator like 1, transcript variant 4 (from RefSeq NM_001297671.3)
Gencode Transcript: ENST00000360851.4
Gencode Gene: ENSG00000143344.18
Transcript (Including UTRs)
Position: hg38 chr1:183,805,120-183,928,532 Size: 123,413 Total Exon Count: 18 Strand: +
Coding Region
Position: hg38 chr1:183,805,298-183,926,292 Size: 120,995 Coding Exon Count: 18

Page Index	Sequence and Links	UniProtKB Comments	Primers	MalaCards	CTD
RNA-Seq Expression	Microarray Expression	RNA Structure	Protein Structure	Other Species	GO Annotations
mRNA Descriptions	Pathways	Other Names	Methods

Data last updated at UCSC: 2026-07-12 09:30:09

Sequence and Links to Tools and Databases

Genomic Sequence (chr1:183,805,120-183,928,532)			mRNA (may differ from genome)		Protein (768 aa)
Gene Sorter	Genome Browser	Other Species FASTA	Gene interactions	Table Schema	AlphaFold
BioGPS	Ensembl	Entrez Gene	ExonPrimer	Gencode	GeneCards
HGNC	Lynx	Malacards	MGI	OMIM	PubMed
Reactome	UniProtKB	BioGrid CRISPR DB

Comments and Description Text from UniProtKB


	ID: RGL1_HUMAN DESCRIPTION: RecName: Full=Ral guanine nucleotide dissociation stimulator-like 1; Short=RalGDS-like 1; FUNCTION: Probable guanine nucleotide exchange factor. SUBUNIT: Interacts with Ras (By similarity). TISSUE SPECIFICITY: Expressed in a wide variety of tissues with strong expression being seen in the heart, brain, kidney, spleen and testis. SIMILARITY: Contains 1 N-terminal Ras-GEF domain. SIMILARITY: Contains 1 Ras-associating domain. SIMILARITY: Contains 1 Ras-GEF domain. SEQUENCE CAUTION: Sequence=BAA76803.1; Type=Erroneous initiation;

Primer design for this transcript

Primer3Plus can design qPCR Primers that straddle exon-exon-junctions, which amplify only cDNA, not genomic DNA.
Click here to load the transcript sequence and exon structure into Primer3Plus

Exonprimer can design one pair of Sanger sequencing primers around every exon, located in non-genic sequence.
Click here to open Exonprimer with this transcript

To design primers for a non-coding sequence, zoom to a region of interest and select from the drop-down menu: View > In External Tools > Primer3

MalaCards Disease Associations


	MalaCards Gene Search: RGL1 Diseases sorted by gene-association score: nutritional optic neuropathy (18), toxic optic neuropathy (17)

Comparative Toxicogenomics Database (CTD)


	The following chemicals interact with this gene D000082 Acetaminophen D001564 Benzo(a)pyrene D019327 Copper Sulfate D013749 Tetrachlorodibenzodioxin C404910 2,2-bis(4-hydroxyphenyl)-1,1,1-trichloroethane C023514 2,6-dinitrotoluene D000535 Aluminum D000242 Cyclic AMP D003561 Cytarabine D004317 Doxorubicin more ... click here to view the complete list

RNA-Seq Expression Data from GTEx (53 Tissues, 570 Donors)


	Highest median expression: 26.32 RPKM in Spleen Total median expression: 476.76 RPKM View in GTEx track of Genome Browser View at GTEx portal View GTEx Body Map

Microarray Expression Data

mRNA Secondary Structure of 3' and 5' UTRs

Region	Fold Energy	Bases	Energy/Base	Display As
5' UTR	-90.30	178	-0.507	Picture	PostScript	Text
3' UTR	-635.30	2240	-0.284	Picture	PostScript	Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

Protein Domain and Structure Information

InterPro Domains: Graphical view of domain structure
IPR000159 - Ras-assoc
IPR000651 - Ras-like_Gua-exchang_fac_N
IPR019804 - Ras_G-nucl-exch_fac_CS
IPR008937 - Ras_GEF
IPR023578 - Ras_GEF_dom
IPR001895 - RasGRF_CDC25

Pfam Domains:
PF00788 - Ras association (RalGDS/AF-6) domain
PF00617 - RasGEF domain
PF00618 - RasGEF N-terminal motif

ModBase Predicted Comparative 3D Structure on Q9NZL6


Front	Top	Side

The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.

Orthologous Genes in Other Species

Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.

Mouse	Rat	Zebrafish	D. melanogaster	C. elegans	S. cerevisiae
Genome Browser	Genome Browser	Genome Browser	No ortholog	Genome Browser	No ortholog
Gene Details
Gene Sorter
MGI	RGD	Ensembl		WormBase
Protein Sequence	Protein Sequence	Protein Sequence		Protein Sequence
Alignment	Alignment	Alignment		Alignment

Gene Ontology (GO) Annotations with Structured Vocabulary


	Molecular Function: GO:0005085 guanyl-nucleotide exchange factor activity GO:0005515 protein binding GO:0008321 Ral guanyl-nucleotide exchange factor activity Biological Process: GO:0007165 signal transduction GO:0007264 small GTPase mediated signal transduction GO:0019216 regulation of lipid metabolic process Cellular Component: GO:0005575 cellular_component GO:0005829 cytosol

Descriptions from all associated GenBank mRNAs


	AF186780 - Homo sapiens RGL protein (RGL) mRNA, alternatively spliced product, complete cds. BX537416 - Homo sapiens mRNA; cDNA DKFZp686C2469 (from clone DKFZp686C2469); complete cds. AK316526 - Homo sapiens cDNA, FLJ79425 complete cds, highly similar to Ral guanine nucleotide dissociation stimulator-like 1. AK295179 - Homo sapiens cDNA FLJ50518 complete cds, highly similar to Ral guanine nucleotide dissociation stimulator-like 1. AK295611 - Homo sapiens cDNA FLJ50530 complete cds, highly similar to Ral guanine nucleotide dissociation stimulator-like 1. BC136591 - Homo sapiens ral guanine nucleotide dissociation stimulator-like 1, mRNA (cDNA clone MGC:168204 IMAGE:9020581), complete cds. KJ893334 - Synthetic construct Homo sapiens clone ccsbBroadEn_02728 RGL1 gene, encodes complete protein. AF186779 - Homo sapiens RGL protein (RGL) mRNA, complete cds. AB023176 - Homo sapiens KIAA0959 mRNA for KIAA0959 protein. AK304293 - Homo sapiens cDNA FLJ52394 complete cds, highly similar to Ral guanine nucleotide dissociation stimulator-like 1. BC039250 - Homo sapiens cDNA clone IMAGE:5276283, containing frame-shift errors. AB384060 - Synthetic construct DNA, clone: pF1KSDA0959, Homo sapiens RGL1 gene for ral guanine nucleotide dissociation stimulator-like 1, complete cds, without stop codon, in Flexi system. AL080117 - Homo sapiens mRNA; cDNA DKFZp564D2123 (from clone DKFZp564D2123); partial cds. AK311716 - Homo sapiens cDNA, FLJ18758. AK309237 - Homo sapiens cDNA, FLJ99278. AK311701 - Homo sapiens cDNA, FLJ18743. JD186494 - Sequence 167518 from Patent EP1572962. JD268710 - Sequence 249734 from Patent EP1572962. JD214224 - Sequence 195248 from Patent EP1572962. JD202492 - Sequence 183516 from Patent EP1572962. JD097031 - Sequence 78055 from Patent EP1572962. JD363413 - Sequence 344437 from Patent EP1572962. JD049503 - Sequence 30527 from Patent EP1572962. JD062441 - Sequence 43465 from Patent EP1572962. JD263600 - Sequence 244624 from Patent EP1572962. JD444633 - Sequence 425657 from Patent EP1572962. JD411570 - Sequence 392594 from Patent EP1572962. JD232312 - Sequence 213336 from Patent EP1572962. JD381932 - Sequence 362956 from Patent EP1572962. JD302031 - Sequence 283055 from Patent EP1572962. JD548378 - Sequence 529402 from Patent EP1572962. JD335868 - Sequence 316892 from Patent EP1572962. JD239343 - Sequence 220367 from Patent EP1572962. JD153969 - Sequence 134993 from Patent EP1572962. JD183638 - Sequence 164662 from Patent EP1572962. JD127463 - Sequence 108487 from Patent EP1572962. JD132159 - Sequence 113183 from Patent EP1572962. JD273728 - Sequence 254752 from Patent EP1572962. JD201873 - Sequence 182897 from Patent EP1572962. JD339601 - Sequence 320625 from Patent EP1572962. JD320508 - Sequence 301532 from Patent EP1572962. JD238833 - Sequence 219857 from Patent EP1572962.

Biochemical and Signaling Pathways


	Reactome (by CSHL, EBI, and GO) Protein Q9NZL6 (Reactome details) participates in the following event(s): R-HSA-1989781 PPARA activates gene expression R-HSA-400206 Regulation of lipid metabolism by Peroxisome proliferator-activated receptor alpha (PPARalpha) R-HSA-556833 Metabolism of lipids R-HSA-1430728 Metabolism

Other Names for This Gene


	Alternate Gene Symbols: ENST00000360851.1, ENST00000360851.2, ENST00000360851.3, KIAA0959, NM_001297671, Q5SXQ2, Q5SXQ6, Q9HBY3, Q9HBY4, Q9NZL5, Q9NZL6, Q9UG43, Q9Y2G6, RGL, RGL1_HUMAN, uc001gqo.1, uc001gqo.2, uc001gqo.3, uc001gqo.4, uc001gqo.5 UCSC ID: ENST00000360851.4 RefSeq Accession: NM_001297671.3 Protein: Q9NZL6 (aka RGL1_HUMAN) CCDS: CCDS72992.1

Methods, Credits, and Use Restrictions


	Click here for details on how this gene model was made and data restrictions if any.

GNF Expression Atlas 2 Data from U133A and GNF1H Chips