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Human Gene RNASE4 (ENST00000555835.3) from GENCODE V50
  Description: ribonuclease A family member 4, transcript variant 2 (from RefSeq NM_002937.5)
Gencode Transcript: ENST00000555835.3
Gencode Gene: ENSG00000258818.6
Transcript (Including UTRs)
   Position: hg38 chr14:20,684,560-20,701,216 Size: 16,657 Total Exon Count: 2 Strand: +
Coding Region
   Position: hg38 chr14:20,699,372-20,699,815 Size: 444 Coding Exon Count: 1 

Page IndexSequence and LinksUniProtKB CommentsPrimersMalaCardsCTD
RNA StructureProtein StructureOther SpeciesGO AnnotationsmRNA DescriptionsOther Names
Methods
Data last updated at UCSC: 2026-07-12 09:30:09

-  Comments and Description Text from UniProtKB
  ID: Q53XB4_HUMAN
DESCRIPTION: SubName: Full=Full-length cDNA clone CS0DF032YM23 of Fetal brain of Homo sapiens (human); SubName: Full=Full-length cDNA clone CS0DM007YH13 of Fetal liver of Homo sapiens (human); SubName: Full=HCG2044782, isoform CRA_a; SubName: Full=cDNA FLJ35103 fis, clone PLACE6006549, highly similar to RIBONUCLEASE 4 (EC 3.1.27.-);
SIMILARITY: Belongs to the pancreatic ribonuclease family.

-  Primer design for this transcript
 

Primer3Plus can design qPCR Primers that straddle exon-exon-junctions, which amplify only cDNA, not genomic DNA.
Click here to load the transcript sequence and exon structure into Primer3Plus

Exonprimer can design one pair of Sanger sequencing primers around every exon, located in non-genic sequence.
Click here to open Exonprimer with this transcript

To design primers for a non-coding sequence, zoom to a region of interest and select from the drop-down menu: View > In External Tools > Primer3


-  MalaCards Disease Associations
  MalaCards Gene Search: RNASE4
Diseases sorted by gene-association score: amyotrophic lateral sclerosis 1 (1)

-  Comparative Toxicogenomics Database (CTD)
  The following chemicals interact with this gene           more ... click here to view the complete list

-  mRNA Secondary Structure of 3' and 5' UTRs
 
RegionFold EnergyBasesEnergy/Base
Display As
5' UTR -53.90216-0.250 Picture PostScript Text
3' UTR -295.001401-0.211 Picture PostScript Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

-  Protein Domain and Structure Information
  InterPro Domains: Graphical view of domain structure
IPR001427 - RNaseA
IPR023411 - RNaseA_AS
IPR023412 - RNaseA_domain

Pfam Domains:
PF00074 - Pancreatic ribonuclease

ModBase Predicted Comparative 3D Structure on Q53XB4
FrontTopSide
The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.

-  Orthologous Genes in Other Species
  Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
MouseRatZebrafishD. melanogasterC. elegansS. cerevisiae
Genome BrowserGenome BrowserNo orthologNo orthologNo orthologNo ortholog
Gene Details     
Gene Sorter     
MGIRGD    
Protein SequenceProtein Sequence    
AlignmentAlignment    

-  Gene Ontology (GO) Annotations with Structured Vocabulary
  Molecular Function:
GO:0003676 nucleic acid binding
GO:0004518 nuclease activity
GO:0004519 endonuclease activity
GO:0016787 hydrolase activity

Biological Process:
GO:0090305 nucleic acid phosphodiester bond hydrolysis


-  Descriptions from all associated GenBank mRNAs
  FJ236304 - Homo sapiens epididymis luminal protein 168 (HEL168) mRNA, complete cds.
AK092422 - Homo sapiens cDNA FLJ35103 fis, clone PLACE6006549, highly similar to RIBONUCLEASE 4 PRECURSOR (EC 3.1.27.-).
LF384987 - JP 2014500723-A/192490: Polycomb-Associated Non-Coding RNAs.
MA620564 - JP 2018138019-A/192490: Polycomb-Associated Non-Coding RNAs.
BX247985 - human full-length cDNA clone CS0DF032YM23 of Fetal brain of Homo sapiens (human).
AK313989 - Homo sapiens cDNA, FLJ94641, Homo sapiens angiogenin, ribonuclease, RNase A family, 5 (ANG),mRNA.
BC015520 - Homo sapiens ribonuclease, RNase A family, 4, mRNA (cDNA clone MGC:9306 IMAGE:3905439), complete cds.
GQ900976 - Homo sapiens clone HEL-T-88 epididymis secretory sperm binding protein mRNA, complete cds.
BC054880 - Homo sapiens angiogenin, ribonuclease, RNase A family, 5, mRNA (cDNA clone MGC:61969 IMAGE:6453640), complete cds.
LF334359 - JP 2014500723-A/141862: Polycomb-Associated Non-Coding RNAs.
MA569936 - JP 2018138019-A/141862: Polycomb-Associated Non-Coding RNAs.
BX248010 - human full-length cDNA clone CS0DM007YH13 of Fetal liver of Homo sapiens (human).
JD249211 - Sequence 230235 from Patent EP1572962.
JD315954 - Sequence 296978 from Patent EP1572962.
D37931 - Homo sapiens mRNA for RNase 4, complete cds.
JD417417 - Sequence 398441 from Patent EP1572962.
KJ892012 - Synthetic construct Homo sapiens clone ccsbBroadEn_01406 RNASE4 gene, encodes complete protein.
LF334363 - JP 2014500723-A/141866: Polycomb-Associated Non-Coding RNAs.
MA569940 - JP 2018138019-A/141866: Polycomb-Associated Non-Coding RNAs.
LF334364 - JP 2014500723-A/141867: Polycomb-Associated Non-Coding RNAs.
MA569941 - JP 2018138019-A/141867: Polycomb-Associated Non-Coding RNAs.
JD119225 - Sequence 100249 from Patent EP1572962.
JD480280 - Sequence 461304 from Patent EP1572962.
JD305417 - Sequence 286441 from Patent EP1572962.
JD510094 - Sequence 491118 from Patent EP1572962.
JD174757 - Sequence 155781 from Patent EP1572962.
JD300525 - Sequence 281549 from Patent EP1572962.

-  Other Names for This Gene
  Alternate Gene Symbols: ENST00000555835.1, ENST00000555835.2, hCG_2044782 , NM_002937, Q53XB4, Q53XB4_HUMAN, RAB1 , uc001vxy.1, uc001vxy.2, uc001vxy.3, uc001vxy.4, uc001vxy.5, uc001vxy.6, uc001vxy.7
UCSC ID: ENST00000555835.3
RefSeq Accession: NM_002937.5
Protein: Q53XB4 CCDS: CCDS9555.1

-  Methods, Credits, and Use Restrictions
  Click here for details on how this gene model was made and data restrictions if any.