ID:TR13C_HUMAN DESCRIPTION: RecName: Full=Tumor necrosis factor receptor superfamily member 13C; AltName: Full=B-cell-activating factor receptor; AltName: Full=BAFF receptor; Short=BAFF-R; AltName: Full=BLyS receptor 3; AltName: CD_antigen=CD268; FUNCTION: B-cell receptor specific for TNFSF13B/TALL1/BAFF/BLyS. Promotes the survival of mature B-cells and the B-cell response. SUBCELLULAR LOCATION: Membrane; Single-pass type III membrane protein (Probable). TISSUE SPECIFICITY: Highly expressed in spleen and lymph node, and in resting B-cells. Detected at lower levels in activated B-cells, resting CD4+ T-cells, in thymus and peripheral blood leukocytes. DISEASE: Defects in TNFRSF13C are the cause of immunodeficiency common variable type 4 (CVID4) [MIM:613494]; also called antibody deficiency due to BAFFR defect. CVID4 is a primary immunodeficiency characterized by antibody deficiency, hypogammaglobulinemia, recurrent bacterial infections and an inability to mount an antibody response to antigen. The defect results from a failure of B-cell differentiation and impaired secretion of immunoglobulins; the numbers of circulating B-cells is usually in the normal range, but can be low. SIMILARITY: Contains 1 TNFR-Cys repeat. WEB RESOURCE: Name=GeneReviews; URL="http://www.ncbi.nlm.nih.gov/sites/GeneTests/lab/gene/TNFRSF13C";
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
ModBase Predicted Comparative 3D Structure on Q96RJ3
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
Gene Ontology (GO) Annotations with Structured Vocabulary
Biological Process: GO:0001782 B cell homeostasis GO:0002250 adaptive immune response GO:0002376 immune system process GO:0002636 positive regulation of germinal center formation GO:0030890 positive regulation of B cell proliferation GO:0031295 T cell costimulation GO:0031296 B cell costimulation GO:0033209 tumor necrosis factor-mediated signaling pathway GO:0042102 positive regulation of T cell proliferation GO:0045078 positive regulation of interferon-gamma biosynthetic process GO:0050776 regulation of immune response
BC156502 - Synthetic construct Homo sapiens clone IMAGE:100063133, MGC:190700 transcription factor 20 (AR1) (TCF20) mRNA, encodes complete protein. AK128410 - Homo sapiens cDNA FLJ46553 fis, clone THYMU3038879. JD228793 - Sequence 209817 from Patent EP1572962. JD275874 - Sequence 256898 from Patent EP1572962. JD419739 - Sequence 400763 from Patent EP1572962. JD188440 - Sequence 169464 from Patent EP1572962. HZ408431 - JP 2015528002-A/1028: CHIRAL CONTROL. LG051765 - KR 1020150036642-A/1031: CHIRAL CONTROL. HZ480389 - JP 2015535430-A/895: TERMINALLY MODIFIED RNA. HZ790320 - JP 2016504050-A/2065: SIGNAL-SENSOR POLYNUCLEOTIDES FOR THE ALTERATION OF CELLULAR PHENOTYPES. JC513052 - Sequence 3305 from Patent WO2014113089. LF160469 - JP 2016513950-A/535: Oligomers with improved off-target profile. LP951620 - Sequence 126 from Patent WO2017157650. LQ070640 - Sequence 964 from Patent EP2964234. MA644141 - JP 2017113010-A/2065: SIGNAL-SENSOR POLYNUCLEOTIDES FOR THE ALTERATION OF CELLULAR PHENOTYPES. MA732025 - JP 2017140048-A/895: TERMINALLY MODIFIED RNA. JD309075 - Sequence 290099 from Patent EP1572962. JD095170 - Sequence 76194 from Patent EP1572962. JD457273 - Sequence 438297 from Patent EP1572962. JD200211 - Sequence 181235 from Patent EP1572962. JD270485 - Sequence 251509 from Patent EP1572962. JD293173 - Sequence 274197 from Patent EP1572962. JD197523 - Sequence 178547 from Patent EP1572962. JD318206 - Sequence 299230 from Patent EP1572962. JD330992 - Sequence 312016 from Patent EP1572962. JD330993 - Sequence 312017 from Patent EP1572962. JD409402 - Sequence 390426 from Patent EP1572962. JD242704 - Sequence 223728 from Patent EP1572962. JD123177 - Sequence 104201 from Patent EP1572962. JD514082 - Sequence 495106 from Patent EP1572962. JD151010 - Sequence 132034 from Patent EP1572962. JD139546 - Sequence 120570 from Patent EP1572962. JD140625 - Sequence 121649 from Patent EP1572962. JD198435 - Sequence 179459 from Patent EP1572962. JD523604 - Sequence 504628 from Patent EP1572962. JD153215 - Sequence 134239 from Patent EP1572962. AF373846 - Homo sapiens BAFF receptor mRNA, complete cds. AX772914 - Sequence 1 from Patent WO03045422. AX800072 - Sequence 1 from Patent WO03055509. JD263878 - Sequence 244902 from Patent EP1572962. JD162860 - Sequence 143884 from Patent EP1572962. JD389220 - Sequence 370244 from Patent EP1572962. JD450980 - Sequence 432004 from Patent EP1572962. JD338393 - Sequence 319417 from Patent EP1572962. BC105123 - Homo sapiens tumor necrosis factor receptor superfamily, member 13C, mRNA (cDNA clone MGC:132783 IMAGE:8144126), complete cds. BC112030 - Homo sapiens tumor necrosis factor receptor superfamily, member 13C, mRNA (cDNA clone MGC:138235 IMAGE:8327498), complete cds. JD455584 - Sequence 436608 from Patent EP1572962. JD452832 - Sequence 433856 from Patent EP1572962. JD458903 - Sequence 439927 from Patent EP1572962. BC111585 - Synthetic construct Homo sapiens clone IMAGE:40080564, MGC:133427 TNFRSF13C protein (TNFRSF13C) mRNA, encodes complete protein. AB590047 - Synthetic construct DNA, clone: pFN21AB7182, Homo sapiens TNFRSF13C gene for tumor necrosis factor receptor superfamily, member 13C, without stop codon, in Flexi system. MA801194 - JP 2018183181-A/2065: SIGNAL-SENSOR POLYNUCLEOTIDES FOR THE ALTERATION OF CELLULAR PHENOTYPES. MP114335 - Sequence 44 from Patent WO2019053235. MP114324 - Sequence 33 from Patent WO2019053235. MP168066 - Sequence 73 from Patent EP3469101. MB408318 - WO 2019163900-A/25: Method of analysis and diagnose using RNA modification. MB481493 - JP 2019528758-A/73: Methods And Compositions For Prostate Cancer Diagnosis And Treatment.
Biochemical and Signaling Pathways
KEGG - Kyoto Encyclopedia of Genes and Genomes hsa04060 - Cytokine-cytokine receptor interaction hsa04672 - Intestinal immune network for IgA production hsa05340 - Primary immunodeficiency
BioCarta from NCI Cancer Genome Anatomy Project h_tall1Pathway - TACI and BCMA stimulation of B cell immune responses.
Reactome (by CSHL, EBI, and GO)
Protein Q96RJ3 (Reactome details) participates in the following event(s):
Sequence and Links to Tools and Databases 
