ID:TOM6_HUMAN DESCRIPTION: RecName: Full=Mitochondrial import receptor subunit TOM6 homolog; AltName: Full=Overexpressed breast tumor protein; AltName: Full=Translocase of outer membrane 6 kDa subunit homolog; SUBUNIT: Forms part of the preprotein translocase complex of the outer mitochondrial membrane (TOM complex) which consists of at least 7 different proteins (TOMM5, TOMM6, TOMM7, TOMM20, TOMM22, TOMM40 and TOMM70). SUBCELLULAR LOCATION: Mitochondrion outer membrane. SIMILARITY: Belongs to the Tom6 family.
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
Protein Domain and Structure Information
ModBase Predicted Comparative 3D Structure on Q96B49
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
AL137721 - Homo sapiens mRNA; cDNA DKFZp761H221 (from clone DKFZp761H221). BC027896 - Homo sapiens prickle homolog 4 (Drosophila), mRNA (cDNA clone IMAGE:5227576). AK057184 - Homo sapiens cDNA FLJ32622 fis, clone STOMA2000396, weakly similar to LIM-ONLY PROTEIN 6. AJ420506 - Homo sapiens mRNA full length insert cDNA clone EUROIMAGE 2097025. BC015975 - Homo sapiens translocase of outer mitochondrial membrane 6 homolog (yeast), mRNA (cDNA clone IMAGE:4133975), complete cds. BC107435 - Homo sapiens chromosome 6 open reading frame 49, mRNA (cDNA clone IMAGE:6717057). AF216754 - Homo sapiens over-expressed breast tumor protein (OBTP) mRNA, complete cds. BC018624 - Homo sapiens translocase of outer mitochondrial membrane 6 homolog (yeast), mRNA (cDNA clone IMAGE:4642696), complete cds. BC067252 - Homo sapiens translocase of outer mitochondrial membrane 6 homolog (yeast), mRNA (cDNA clone IMAGE:6527370), with apparent retained intron. BC022274 - Homo sapiens translocase of outer mitochondrial membrane 6 homolog (yeast), mRNA (cDNA clone IMAGE:4739245), complete cds. AB435319 - Homo sapiens Tom6 mRNA for mitochondrial outer membrane protein TOM6, complete cds. KJ896353 - Synthetic construct Homo sapiens clone ccsbBroadEn_05747 TOMM6 gene, encodes complete protein. L34839 - Homo sapiens over-expressed breast tumor protein mRNA. JD313469 - Sequence 294493 from Patent EP1572962. JD431312 - Sequence 412336 from Patent EP1572962. JD117999 - Sequence 99023 from Patent EP1572962. JD372480 - Sequence 353504 from Patent EP1572962. JD333173 - Sequence 314197 from Patent EP1572962. JD528814 - Sequence 509838 from Patent EP1572962. JD536474 - Sequence 517498 from Patent EP1572962. DL491425 - Novel nucleic acids. DL490047 - Novel nucleic acids.
Biochemical and Signaling Pathways
Reactome (by CSHL, EBI, and GO)
Protein Q96B49 (Reactome details) participates in the following event(s):
R-HSA-1268022 TOMM40 complex translocates proteins from the cytosol to the mitochondrial intermembrane space R-HSA-5205661 Pink1 is recruited from the cytoplasm to the mitochondria R-HSA-1268020 Mitochondrial protein import R-HSA-5205685 Pink/Parkin Mediated Mitophagy R-HSA-392499 Metabolism of proteins R-HSA-5205647 Mitophagy
Sequence and Links to Tools and Databases 
Microarray Expression Data 
