Human Gene ADPRS (ENST00000373178.5) from GENCODE V44
Description: Homo sapiens ADP-ribosylserine hydrolase (ADPRS), mRNA. (from RefSeq NM_017825) RefSeq Summary (NM_017825): This gene encodes a member of the ADP-ribosylglycohydrolase family. The encoded enzyme catalyzes the removal of ADP-ribose from ADP-ribosylated proteins. This enzyme localizes to the mitochondria, in addition to the nucleus and cytoplasm.[provided by RefSeq, Feb 2009]. Gencode Transcript: ENST00000373178.5 Gencode Gene: ENSG00000116863.11 Transcript (Including UTRs) Position: hg38 chr1:36,088,892-36,093,932 Size: 5,041 Total Exon Count: 6 Strand: + Coding Region Position: hg38 chr1:36,088,905-36,093,386 Size: 4,482 Coding Exon Count: 6
ID:ARHL2_HUMAN DESCRIPTION: RecName: Full=Poly(ADP-ribose) glycohydrolase ARH3; EC=3.2.1.143; AltName: Full=ADP-ribosylhydrolase 3; AltName: Full=[Protein ADP-ribosylarginine] hydrolase-like protein 2; FUNCTION: Poly(ADP-ribose) synthesized after DNA damage is only present transiently and is rapidly degraded by poly(ADP-ribose) glycohydrolase. Poly(ADP-ribose) metabolism may be required for maintenance of the normal function of neuronal cells. Generates ADP-ribose from poly-(ADP-ribose), but does not hydrolyze ADP- ribose-arginine, -cysteine, -diphthamide, or -asparagine bonds. CATALYTIC ACTIVITY: Hydrolyzes poly(ADP-ribose) at glycosidic (1''-2') linkage of ribose-ribose bond to produce free ADP-ribose. COFACTOR: Binds 2 magnesium ions per subunit. ENZYME REGULATION: Activity is enhanced by magnesium. SUBUNIT: Monomer (By similarity). SUBCELLULAR LOCATION: Cytoplasm (By similarity). Nucleus. TISSUE SPECIFICITY: Ubiquitous. SIMILARITY: Belongs to the ADP-ribosylglycohydrolase family. SEQUENCE CAUTION: Sequence=AAK14922.1; Type=Frameshift; Positions=Several;
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
ModBase Predicted Comparative 3D Structure on Q9NX46
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
AF212236 - Homo sapiens HPHase mRNA, complete cds. AJ427295 - Homo sapiens mRNA for ecto-ADP-ribosylhydrolase (arh3 gene). AK000453 - Homo sapiens cDNA FLJ20446 fis, clone KAT05231. AK295283 - Homo sapiens cDNA FLJ51852 complete cds, highly similar to Homo sapiens ADP-ribosylhydrolase like 2 (ADPRHL2), mRNA. BC014169 - Homo sapiens ADP-ribosylhydrolase like 2, mRNA (cDNA clone MGC:20733 IMAGE:4552006), complete cds. AK316349 - Homo sapiens cDNA, FLJ79248 complete cds, highly similar to Homo sapiens ADP-ribosylhydrolase like 2 (ADPRHL2), mRNA. AK223037 - Homo sapiens mRNA for ADP-ribosylhydrolase like 2 variant, clone: JTH00753. CR457237 - Homo sapiens full open reading frame cDNA clone RZPDo834C0419D for gene ADPRHL2, ADP-ribosylhydrolase like 2; complete cds, incl. stopcodon. KJ894094 - Synthetic construct Homo sapiens clone ccsbBroadEn_03488 ADPRHL2 gene, encodes complete protein. JD095537 - Sequence 76561 from Patent EP1572962. JD423186 - Sequence 404210 from Patent EP1572962. JD181266 - Sequence 162290 from Patent EP1572962. JD347575 - Sequence 328599 from Patent EP1572962. JD338510 - Sequence 319534 from Patent EP1572962. JD533413 - Sequence 514437 from Patent EP1572962. JD464666 - Sequence 445690 from Patent EP1572962. JD359566 - Sequence 340590 from Patent EP1572962. JD561601 - Sequence 542625 from Patent EP1572962. JD550601 - Sequence 531625 from Patent EP1572962. JD563475 - Sequence 544499 from Patent EP1572962. JD111365 - Sequence 92389 from Patent EP1572962.
Biochemical and Signaling Pathways
Reactome (by CSHL, EBI, and GO)
Protein Q9NX46 (Reactome details) participates in the following event(s):
R-HSA-110362 POLB-Dependent Long Patch Base Excision Repair R-HSA-110373 Resolution of AP sites via the multiple-nucleotide patch replacement pathway R-HSA-73933 Resolution of Abasic Sites (AP sites) R-HSA-73884 Base Excision Repair R-HSA-73894 DNA Repair