Human Gene BMP2 (ENST00000378827.5) from GENCODE V44
Description: Homo sapiens bone morphogenetic protein 2 (BMP2), mRNA. (from RefSeq NM_001200) RefSeq Summary (NM_001200): This gene encodes a secreted ligand of the TGF-beta (transforming growth factor-beta) superfamily of proteins. Ligands of this family bind various TGF-beta receptors leading to recruitment and activation of SMAD family transcription factors that regulate gene expression. The encoded preproprotein is proteolytically processed to generate each subunit of the disulfide-linked homodimer, which plays a role in bone and cartilage development. Duplication of a regulatory region downstream of this gene causes a form of brachydactyly characterized by a malformed index finger and second toe in human patients. [provided by RefSeq, Jul 2016]. Gencode Transcript: ENST00000378827.5 Gencode Gene: ENSG00000125845.7 Transcript (Including UTRs) Position: hg38 chr20:6,767,686-6,780,246 Size: 12,561 Total Exon Count: 3 Strand: + Coding Region Position: hg38 chr20:6,770,127-6,779,089 Size: 8,963 Coding Exon Count: 2
ID:BMP2_HUMAN DESCRIPTION: RecName: Full=Bone morphogenetic protein 2; Short=BMP-2; AltName: Full=Bone morphogenetic protein 2A; Short=BMP-2A; Flags: Precursor; FUNCTION: Induces cartilage and bone formation. SUBUNIT: Homodimer; disulfide-linked. Interacts with SOSTDC1. Interacts with GREM2, RGMA, RGMB and RGMC. Interacts with ASPN (By similarity). INTERACTION: P36894:BMPR1A; NbExp=2; IntAct=EBI-1029262, EBI-1029237; SUBCELLULAR LOCATION: Secreted. TISSUE SPECIFICITY: Particularly abundant in lung, spleen and colon and in low but significant levels in heart, brain, placenta, liver, skeletal muscle, kidney, pancreas, prostate, ovary and small intestine. PHARMACEUTICAL: Available under the name Infuse (Medtronic Sofamor Danek). Used for treating open tibial shaft fractures. SIMILARITY: Belongs to the TGF-beta family. WEB RESOURCE: Name=Wikipedia; Note=Bone morphogenetic protein 2 entry; URL="http://en.wikipedia.org/wiki/Bone_morphogenetic_protein_2";
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
ModBase Predicted Comparative 3D Structure on P12643
Front
Top
Side
The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.
Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
BioCarta from NCI Cancer Genome Anatomy Project h_alkPathway - ALK in cardiac myocytes
Reactome (by CSHL, EBI, and GO)
Protein P12643 (Reactome details) participates in the following event(s):
R-HSA-201457 BMP2 binds to the receptor complex R-HSA-201810 The ligand trap binds the ligand BMP2, blocking BMP signalling R-HSA-2396399 Fibrillins bind BMPs R-HSA-201475 I-Smad competes with R-Smad1/5/8 for type I receptor R-HSA-201648 An anchoring protein, Endofin, recruits R-Smad1/5/8 R-HSA-201821 I-Smad binds to type I receptor, preventing Smad1/5/8 from being activated R-HSA-201443 Type II receptor phosphorylates type I receptor R-HSA-201453 Phospho-R-Smad1/5/8 dissociates from the receptor complex R-HSA-201476 Activated type I receptor phosphorylates R-Smad1/5/8 directly R-HSA-201451 Signaling by BMP R-HSA-2129379 Molecules associated with elastic fibres R-HSA-9006936 Signaling by TGF-beta family members R-HSA-1566948 Elastic fibre formation R-HSA-162582 Signal Transduction R-HSA-1474244 Extracellular matrix organization
US Server
