Human Gene CCDC47 (ENST00000225726.10)
  Description: Homo sapiens coiled-coil domain containing 47 (CCDC47), mRNA. (from RefSeq NM_020198)
Gencode Transcript: ENST00000225726.10
Gencode Gene: ENSG00000108588.14
Transcript (Including UTRs)
   Position: hg38 chr17:63,745,255-63,773,597 Size: 28,343 Total Exon Count: 13 Strand: -
Coding Region
   Position: hg38 chr17:63,746,881-63,766,175 Size: 19,295 Coding Exon Count: 12 

Page IndexSequence and LinksUniProtKB CommentsCTDRNA-Seq ExpressionMicroarray Expression
RNA StructureProtein StructureOther SpeciesGO AnnotationsmRNA DescriptionsOther Names
Data last updated at UCSC: 2021-01-14 15:32:12

-  Sequence and Links to Tools and Databases
Genomic Sequence (chr17:63,745,255-63,773,597)mRNA (may differ from genome)Protein (483 aa)
Gene SorterGenome BrowserOther Species FASTAVisiGeneGene interactionsTable Schema
BioGPSCGAPEnsemblEntrez GeneExonPrimerGeneCards

-  Comments and Description Text from UniProtKB
DESCRIPTION: RecName: Full=Coiled-coil domain-containing protein 47; Flags: Precursor;
INTERACTION: Q99J34:Irak1 (xeno); NbExp=2; IntAct=EBI-720151, EBI-6117042; Q92985:IRF7; NbExp=2; IntAct=EBI-720151, EBI-968267; Q6PDS3:Sarm1 (xeno); NbExp=2; IntAct=EBI-720151, EBI-6117196; P58753:TIRAP; NbExp=2; IntAct=EBI-720151, EBI-528644; Q86WV6:TMEM173; NbExp=2; IntAct=EBI-720151, EBI-2800345;
SUBCELLULAR LOCATION: Membrane; Single-pass membrane protein (Potential).
SEQUENCE CAUTION: Sequence=AAG39292.1; Type=Frameshift; Positions=306;

-  Comparative Toxicogenomics Database (CTD)
  The following chemicals interact with this gene           more ... click here to view the complete list

-  RNA-Seq Expression Data from GTEx (53 Tissues, 570 Donors)
  Highest median expression: 32.52 RPKM in Adrenal Gland
Total median expression: 1050.62 RPKM

View in GTEx track of Genome Browser    View at GTEx portal     View GTEx Body Map

+  Microarray Expression Data
  Press "+" in the title bar above to open this section.

-  mRNA Secondary Structure of 3' and 5' UTRs
RegionFold EnergyBasesEnergy/Base
Display As
5' UTR -90.40205-0.441 Picture PostScript Text
3' UTR -409.001626-0.252 Picture PostScript Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

-  Protein Domain and Structure Information
  InterPro Domains: Graphical view of domain structure
IPR012879 - DUF1682

Pfam Domains:
PF07946 - Protein of unknown function (DUF1682)

ModBase Predicted Comparative 3D Structure on Q96A33
The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.

-  Orthologous Genes in Other Species
  Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
MouseRatZebrafishD. melanogasterC. elegansS. cerevisiae
Genome BrowserGenome BrowserNo orthologNo orthologNo orthologNo ortholog
Gene Details     
Gene Sorter     
Protein SequenceProtein Sequence    

-  Gene Ontology (GO) Annotations with Structured Vocabulary
  Molecular Function:
GO:0003723 RNA binding
GO:0005509 calcium ion binding
GO:0005515 protein binding

Biological Process:
GO:0001649 osteoblast differentiation
GO:0006983 ER overload response
GO:0007029 endoplasmic reticulum organization
GO:0009791 post-embryonic development
GO:0030433 ER-associated ubiquitin-dependent protein catabolic process
GO:0055074 calcium ion homeostasis

Cellular Component:
GO:0005783 endoplasmic reticulum
GO:0005791 rough endoplasmic reticulum
GO:0016020 membrane
GO:0016021 integral component of membrane

-  Descriptions from all associated GenBank mRNAs
  AF226054 - Homo sapiens GK001 (GK001) mRNA, complete cds.
BC001300 - Homo sapiens coiled-coil domain containing 47, mRNA (cDNA clone IMAGE:3451856).
AX810707 - Sequence 31 from Patent EP1333092.
AK225813 - Homo sapiens mRNA for hypothetical protein LOC57003 variant, clone: FCC129D09.
JD345074 - Sequence 326098 from Patent EP1572962.
JD349488 - Sequence 330512 from Patent EP1572962.
LF328243 - JP 2014500723-A/135746: Polycomb-Associated Non-Coding RNAs.
MA563820 - JP 2018138019-A/135746: Polycomb-Associated Non-Coding RNAs.
JD299772 - Sequence 280796 from Patent EP1572962.
JD200496 - Sequence 181520 from Patent EP1572962.
JD370911 - Sequence 351935 from Patent EP1572962.
JD234778 - Sequence 215802 from Patent EP1572962.
LF328244 - JP 2014500723-A/135747: Polycomb-Associated Non-Coding RNAs.
MA563821 - JP 2018138019-A/135747: Polycomb-Associated Non-Coding RNAs.
JD295347 - Sequence 276371 from Patent EP1572962.
JD075658 - Sequence 56682 from Patent EP1572962.
LF328245 - JP 2014500723-A/135748: Polycomb-Associated Non-Coding RNAs.
MA563822 - JP 2018138019-A/135748: Polycomb-Associated Non-Coding RNAs.
LF328246 - JP 2014500723-A/135749: Polycomb-Associated Non-Coding RNAs.
MA563823 - JP 2018138019-A/135749: Polycomb-Associated Non-Coding RNAs.
JD164659 - Sequence 145683 from Patent EP1572962.
JD402874 - Sequence 383898 from Patent EP1572962.
JD089812 - Sequence 70836 from Patent EP1572962.
JD354914 - Sequence 335938 from Patent EP1572962.
LF328247 - JP 2014500723-A/135750: Polycomb-Associated Non-Coding RNAs.
MA563824 - JP 2018138019-A/135750: Polycomb-Associated Non-Coding RNAs.
LF328248 - JP 2014500723-A/135751: Polycomb-Associated Non-Coding RNAs.
MA563825 - JP 2018138019-A/135751: Polycomb-Associated Non-Coding RNAs.
BC013600 - Homo sapiens coiled-coil domain containing 47, mRNA (cDNA clone IMAGE:3865335), partial cds.
AK027844 - Homo sapiens cDNA FLJ14938 fis, clone PLACE1010622, weakly similar to TROPONIN T, CARDIAC MUSCLE ISOFORMS.
JD092559 - Sequence 73583 from Patent EP1572962.
E10513 - cDNA encoding protein which is produced by glioblastoma.
AK075387 - Homo sapiens cDNA PSEC0077 fis, clone NT2RP2003902, highly similar to GK001 protein.
BC008905 - Homo sapiens coiled-coil domain containing 47, mRNA (cDNA clone MGC:15096 IMAGE:3688068), complete cds.
AF113221 - Homo sapiens MSTP041 mRNA, complete cds.
LF328249 - JP 2014500723-A/135752: Polycomb-Associated Non-Coding RNAs.
MA563826 - JP 2018138019-A/135752: Polycomb-Associated Non-Coding RNAs.
LF328250 - JP 2014500723-A/135753: Polycomb-Associated Non-Coding RNAs.
MA563827 - JP 2018138019-A/135753: Polycomb-Associated Non-Coding RNAs.
JD263714 - Sequence 244738 from Patent EP1572962.
JD375522 - Sequence 356546 from Patent EP1572962.
LF328251 - JP 2014500723-A/135754: Polycomb-Associated Non-Coding RNAs.
MA563828 - JP 2018138019-A/135754: Polycomb-Associated Non-Coding RNAs.
JD455699 - Sequence 436723 from Patent EP1572962.
JD334961 - Sequence 315985 from Patent EP1572962.
JD047060 - Sequence 28084 from Patent EP1572962.
AK314328 - Homo sapiens cDNA, FLJ95088, highly similar to Homo sapiens GK001 protein (GK001), mRNA.
KJ899289 - Synthetic construct Homo sapiens clone ccsbBroadEn_08683 CCDC47 gene, encodes complete protein.
DQ896573 - Synthetic construct Homo sapiens clone IMAGE:100011033; FLH195552.01L; RZPDo839D09151D coiled-coil domain containing 47 (CCDC47) gene, encodes complete protein.
AK027786 - Homo sapiens cDNA FLJ14880 fis, clone PLACE1003369.
LF328252 - JP 2014500723-A/135755: Polycomb-Associated Non-Coding RNAs.
MA563829 - JP 2018138019-A/135755: Polycomb-Associated Non-Coding RNAs.
LF328253 - JP 2014500723-A/135756: Polycomb-Associated Non-Coding RNAs.
MA563830 - JP 2018138019-A/135756: Polycomb-Associated Non-Coding RNAs.
LF328254 - JP 2014500723-A/135757: Polycomb-Associated Non-Coding RNAs.
MA563831 - JP 2018138019-A/135757: Polycomb-Associated Non-Coding RNAs.
LF328255 - JP 2014500723-A/135758: Polycomb-Associated Non-Coding RNAs.
MA563832 - JP 2018138019-A/135758: Polycomb-Associated Non-Coding RNAs.
LF328256 - JP 2014500723-A/135759: Polycomb-Associated Non-Coding RNAs.
MA563833 - JP 2018138019-A/135759: Polycomb-Associated Non-Coding RNAs.
CU679179 - Synthetic construct Homo sapiens gateway clone IMAGE:100017354 5' read CCDC47 mRNA.
LF328259 - JP 2014500723-A/135762: Polycomb-Associated Non-Coding RNAs.
MA563836 - JP 2018138019-A/135762: Polycomb-Associated Non-Coding RNAs.
LF328261 - JP 2014500723-A/135764: Polycomb-Associated Non-Coding RNAs.
MA563838 - JP 2018138019-A/135764: Polycomb-Associated Non-Coding RNAs.
LF328262 - JP 2014500723-A/135765: Polycomb-Associated Non-Coding RNAs.
MA563839 - JP 2018138019-A/135765: Polycomb-Associated Non-Coding RNAs.
LF328263 - JP 2014500723-A/135766: Polycomb-Associated Non-Coding RNAs.
MA563840 - JP 2018138019-A/135766: Polycomb-Associated Non-Coding RNAs.
LF328264 - JP 2014500723-A/135767: Polycomb-Associated Non-Coding RNAs.
MA563841 - JP 2018138019-A/135767: Polycomb-Associated Non-Coding RNAs.
LF328265 - JP 2014500723-A/135768: Polycomb-Associated Non-Coding RNAs.
MA563842 - JP 2018138019-A/135768: Polycomb-Associated Non-Coding RNAs.
LF328266 - JP 2014500723-A/135769: Polycomb-Associated Non-Coding RNAs.
MA563843 - JP 2018138019-A/135769: Polycomb-Associated Non-Coding RNAs.
JD458019 - Sequence 439043 from Patent EP1572962.
JD455400 - Sequence 436424 from Patent EP1572962.
LF328267 - JP 2014500723-A/135770: Polycomb-Associated Non-Coding RNAs.
MA563844 - JP 2018138019-A/135770: Polycomb-Associated Non-Coding RNAs.

-  Other Names for This Gene
  Alternate Gene Symbols: B2RAS8, CCD47_HUMAN, D3DU20, ENST00000225726.1, ENST00000225726.2, ENST00000225726.3, ENST00000225726.4, ENST00000225726.5, ENST00000225726.6, ENST00000225726.7, ENST00000225726.8, ENST00000225726.9, GK001, MSTP041, NM_020198, PSEC0077, Q96A33, Q96D00, Q96JZ7, Q9H3E4, Q9NRG3, uc002jbs.1, uc002jbs.2, uc002jbs.3, uc002jbs.4, uc002jbs.5, uc002jbs.6
UCSC ID: ENST00000225726.10
RefSeq Accession: NM_020198
Protein: Q96A33 (aka CCD47_HUMAN)
CCDS: CCDS11643.1

-  Methods, Credits, and Use Restrictions
  Click here for details on how this gene model was made and data restrictions if any.