Human Gene CEACAM3 (ENST00000357396.8) from GENCODE V44
Description: Homo sapiens CEA cell adhesion molecule 3 (CEACAM3), transcript variant 1, mRNA. (from RefSeq NM_001815) RefSeq Summary (NM_001815): This gene encodes a member of the family of carcinoembryonic antigen-related cell adhesion molecules (CEACAMs), which are used by several bacterial pathogens to bind and invade host cells. The encoded transmembrane protein directs phagocytosis of several bacterial species that is dependent on the small GTPase Rac. It is thought to serve an important role in controlling human-specific pathogens by the innate immune system. Alternatively spliced transcript variants have been described. [provided by RefSeq, Mar 2013]. Gencode Transcript: ENST00000357396.8 Gencode Gene: ENSG00000170956.17 Transcript (Including UTRs) Position: hg38 chr19:41,796,587-41,811,554 Size: 14,968 Total Exon Count: 7 Strand: + Coding Region Position: hg38 chr19:41,796,678-41,811,237 Size: 14,560 Coding Exon Count: 7
ID:CEAM3_HUMAN DESCRIPTION: RecName: Full=Carcinoembryonic antigen-related cell adhesion molecule 3; AltName: Full=Carcinoembryonic antigen CGM1; AltName: CD_antigen=CD66d; Flags: Precursor; FUNCTION: Major granulocyte receptor mediating recognition and efficient opsonin-independent phagocytosis of CEACAM-binding microorganisms, including Neissiria, Moxarella and Haemophilus species, thus playing an important role in the clearance of pathogens by the innate immune system. Responsible for RAC1 stimulation in the course of pathogen phagocytosis. SUBUNIT: Interacts with S100A9/calprotectin. This interaction is calcium-dependent, but independent of CEACAM3 phosphorylation. SUBCELLULAR LOCATION: Membrane; Single-pass type I membrane protein. TISSUE SPECIFICITY: CGM1a, the predominant CGM1 transcript, is granulocyte-specific. Not detected out of the granulocytic lineage, such as monocytes, lymphocytes, spleen, testis, colon, brain, liver, pancreas, thymus, ovary, placenta, skeletal muscle, prostate, small intestine, heart, lung and kidney. DOMAIN: The cytosolic domain is involved in S100A9 interaction. PTM: Tyrosine-phosphorylated in response to microbial binding. Tyr-230 and Tyr-241 are both required for phosphorylation to be detected. SIMILARITY: Belongs to the immunoglobulin superfamily. CEA family. SIMILARITY: Contains 1 Ig-like V-type (immunoglobulin-like) domain. CAUTION: This is not the ortholog of rat CEACAM3.
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
ModBase Predicted Comparative 3D Structure on P40198
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
Mouse
Rat
Zebrafish
D. melanogaster
C. elegans
S. cerevisiae
No ortholog
No ortholog
No ortholog
No ortholog
No ortholog
No ortholog
Gene Ontology (GO) Annotations with Structured Vocabulary
US Server
