Human Gene CENPO (ENST00000380834.7) from GENCODE V44
Description: Homo sapiens centromere protein O (CENPO), transcript variant 1, mRNA. (from RefSeq NM_024322) RefSeq Summary (NM_001322101): This gene encodes a component of the interphase centromere complex. The encoded protein is localized to the centromere throughout the cell cycle and is required for bipolar spindle assembly, chromosome segregation and checkpoint signaling during mitosis. Alternatively spliced transcript variants encoding multiple protein isoforms have been observed for this gene. [provided by RefSeq, Dec 2010]. Gencode Transcript: ENST00000380834.7 Gencode Gene: ENSG00000138092.11 Transcript (Including UTRs) Position: hg38 chr2:24,793,425-24,822,376 Size: 28,952 Total Exon Count: 8 Strand: + Coding Region Position: hg38 chr2:24,793,920-24,817,806 Size: 23,887 Coding Exon Count: 6
ID:CENPO_HUMAN DESCRIPTION: RecName: Full=Centromere protein O; Short=CENP-O; AltName: Full=Interphase centromere complex protein 36; FUNCTION: Component of the CENPA-CAD (nucleosome distal) complex, a complex recruited to centromeres which is involved in assembly of kinetochore proteins, mitotic progression and chromosome segregation. May be involved in incorporation of newly synthesized CENPA into centromeres via its interaction with the CENPA-NAC complex. Modulates the kinetochore-bound levels of NDC80 complex. SUBUNIT: Component of the CENPA-CAD complex, composed of CENPI, CENPK, CENPL, CENPO, CENPP, CENPQ, CENPR and CENPS. The CENPA-CAD complex interacts with the CENPA-NAC complex, at least composed of CENPA, CENPC, CENPH, CENPM, CENPN, CENPT and MLF1IP/CENPU. SUBCELLULAR LOCATION: Nucleus. Chromosome, centromere. Chromosome, centromere, kinetochore. Note=The CENPA-CAD complex is probably recruited on centromeres by the CENPA-NAC complex.
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
ModBase Predicted Comparative 3D Structure on Q9BU64
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
LF384837 - JP 2014500723-A/192340: Polycomb-Associated Non-Coding RNAs. MA620414 - JP 2018138019-A/192340: Polycomb-Associated Non-Coding RNAs. AK027859 - Homo sapiens cDNA FLJ14953 fis, clone PLACE3000160. BC002870 - Homo sapiens centromere protein O, mRNA (cDNA clone MGC:11266 IMAGE:3942844), complete cds. JD449837 - Sequence 430861 from Patent EP1572962. JD201167 - Sequence 182191 from Patent EP1572962. AK315483 - Homo sapiens cDNA, FLJ96546. CU678264 - Synthetic construct Homo sapiens gateway clone IMAGE:100018762 5' read CENPO mRNA. HQ447425 - Synthetic construct Homo sapiens clone IMAGE:100070748; CCSB004416_01 centromere protein O (CENPO) gene, encodes complete protein. KJ894672 - Synthetic construct Homo sapiens clone ccsbBroadEn_04066 CENPO gene, encodes complete protein. JD080473 - Sequence 61497 from Patent EP1572962. JD173813 - Sequence 154837 from Patent EP1572962. JD237383 - Sequence 218407 from Patent EP1572962. JD038983 - Sequence 20007 from Patent EP1572962. JD273014 - Sequence 254038 from Patent EP1572962. JD216282 - Sequence 197306 from Patent EP1572962. JD039233 - Sequence 20257 from Patent EP1572962. JD036703 - Sequence 17727 from Patent EP1572962. DQ590876 - Homo sapiens piRNA piR-57988, complete sequence. DQ572275 - Homo sapiens piRNA piR-40387, complete sequence. DQ590602 - Homo sapiens piRNA piR-57714, complete sequence. DQ599819 - Homo sapiens piRNA piR-37885, complete sequence.
Biochemical and Signaling Pathways
Reactome (by CSHL, EBI, and GO)
Protein Q9BU64 (Reactome details) participates in the following event(s):
R-HSA-606349 Mis18 complex binds the centromere R-HSA-141409 Mad1 binds kinetochore R-HSA-375302 Kinetochore capture of astral microtubules R-HSA-5666129 CDC42:GTP recruits DIAPH2-2 to kinetochores R-HSA-5666169 Kinetochore capture of astral microtubules is positively regulated by CDC42:GTP:p-S196-DIAPH2-2 R-HSA-606326 HJURP:CENPA complex localizes to the centromere R-HSA-141431 MAD2 associates with the Mad1 kinetochore complex R-HSA-141439 Release of activated MAD2 from kinetochores R-HSA-2467811 Separation of sister chromatids R-HSA-2467809 ESPL1 (Separase) cleaves centromeric cohesin R-HSA-5666160 AURKB phosphorylates DIAPH2-2 at kinetochores R-HSA-141422 MAD2 converted to an inhibitory state via interaction with Mad1 R-HSA-1638821 PP2A-B56 dephosphorylates centromeric cohesin R-HSA-1638803 Phosphorylation of cohesin by PLK1 at centromeres R-HSA-2468287 CDK1 phosphorylates CDCA5 (Sororin) at centromeres R-HSA-606279 Deposition of new CENPA-containing nucleosomes at the centromere R-HSA-141444 Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal R-HSA-68877 Mitotic Prometaphase R-HSA-5663220 RHO GTPases Activate Formins R-HSA-774815 Nucleosome assembly R-HSA-2500257 Resolution of Sister Chromatid Cohesion R-HSA-2467813 Separation of Sister Chromatids R-HSA-141424 Amplification of signal from the kinetochores R-HSA-68886 M Phase R-HSA-195258 RHO GTPase Effectors R-HSA-73886 Chromosome Maintenance R-HSA-68882 Mitotic Anaphase R-HSA-69618 Mitotic Spindle Checkpoint R-HSA-69278 Cell Cycle (Mitotic) R-HSA-194315 Signaling by Rho GTPases R-HSA-1640170 Cell Cycle R-HSA-2555396 Mitotic Metaphase and Anaphase R-HSA-69620 Cell Cycle Checkpoints R-HSA-162582 Signal Transduction
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