Mouse Gene Slc25a13 (U164131) Description and Page Index
  Description: Calcium-binding mitochondrial carrier protein Aralar2 (Mitochondrial aspartate glutamate carrier 2) (Solute carrier family 25 member 13) (Citrin).
Transcript (Including UTRs)
   Position: mm8 chr6:5,991,219-6,167,118 Size: 175,900 Total Exon Count: 18 Strand: -
Coding Region
   Position: mm8 chr6:5,992,146-6,167,010 Size: 174,865 Coding Exon Count: 18 

Page IndexSequence and LinksUniProtKB CommentsCTDMicroarray ExpressionRNA Structure
Protein StructureOther SpeciesGO AnnotationsmRNA DescriptionsPathwaysOther Names
Methods
Data last updated: 2006-02-27

-  Sequence and Links to Tools and Databases
 
Genomic Sequence (chr6:5,991,219-6,167,118)mRNA (may differ from genome)Protein (676 aa)
Gene SorterGenome BrowserOther Species FASTATable SchemaBioGPSCGAP
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ReactomeStanford SOURCEUniProtKB

-  Comments and Description Text from UniProtKB
  ID: CMC2_MOUSE
DESCRIPTION: RecName: Full=Calcium-binding mitochondrial carrier protein Aralar2; AltName: Full=Citrin; AltName: Full=Mitochondrial aspartate glutamate carrier 2; AltName: Full=Solute carrier family 25 member 13;
FUNCTION: Catalyzes the calcium-dependent exchange of cytoplasmic glutamate with mitochondrial aspartate across the mitochondrial inner membrane. May have a function in the urea cycle.
SUBCELLULAR LOCATION: Mitochondrion inner membrane; Multi-pass membrane protein (By similarity).
TISSUE SPECIFICITY: At E10.45, expressed in branchial arches and lrfimb and tail buds. At E13.5 expression is predominant in epithelial structures and the forebrain, kidney and liver. Expression in liver is maintained into adulthood.
SIMILARITY: Belongs to the mitochondrial carrier family.
SIMILARITY: Contains 4 EF-hand domains.
SIMILARITY: Contains 3 Solcar repeats.

-  Comparative Toxicogenomics Database (CTD)
  The following chemicals interact with this gene           more ... click here to view the complete list

-  Microarray Expression Data
 
Expression ratio colors:

GNF Expression Atlas 2 Data from GNF1M Mouse Chip

    
     
      
       
     
    
   
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Rinn et. al Sex Gene Expression Data on MOE430A Chip

        
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GNF Expression Atlas Data from U74b Mouse Chip

          
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Affymetrix All Exon Microarrays

           
Ratios

-  mRNA Secondary Structure of 3' and 5' UTRs
 
RegionFold EnergyBasesEnergy/Base
Display As
5' UTR -37.90108-0.351 Picture PostScript Text
3' UTR -238.43927-0.257 Picture PostScript Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

-  Protein Domain and Structure Information
  InterPro Domains: Graphical view of domain structure
IPR011992 - EF-hand-like_dom
IPR018249 - EF_HAND_2
IPR002048 - EF_hand_Ca-bd
IPR002067 - Mit_carrier
IPR018108 - Mitochondrial_sb/sol_carrier
IPR023395 - Mt_carrier_dom

Pfam Domains:
PF00153 - Mitochondrial carrier protein

ModBase Predicted Comparative 3D Structure on Q9QXX4
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The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.

-  Orthologous Genes in Other Species
  Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
HumanRatZebrafishD. melanogasterC. elegansS. cerevisiae
No orthologNo orthologGenome BrowserNo orthologGenome BrowserGenome Browser
Gene Details   Gene DetailsGene Details
Gene Sorter   Gene SorterGene Sorter
  Ensembl WormBaseSGD
  Protein Sequence Protein SequenceProtein Sequence
  Alignment AlignmentAlignment

-  Gene Ontology (GO) Annotations with Structured Vocabulary
  Molecular Function:
GO:0005313 L-glutamate transmembrane transporter activity
GO:0005509 calcium ion binding
GO:0015183 L-aspartate transmembrane transporter activity
GO:0046872 metal ion binding

Biological Process:
GO:0006754 ATP biosynthetic process
GO:0015810 aspartate transport
GO:0015813 L-glutamate transport
GO:0043490 malate-aspartate shuttle
GO:0045333 cellular respiration
GO:0051592 response to calcium ion
GO:0055085 transmembrane transport
GO:0070778 L-aspartate transport

Cellular Component:
GO:0005739 mitochondrion
GO:0005743 mitochondrial inner membrane
GO:0016020 membrane
GO:0016021 integral component of membrane


-  Descriptions from all associated GenBank mRNAs
  AK151180 - Mus musculus bone marrow macrophage cDNA, RIKEN full-length enriched library, clone:I830026G15 product:solute carrier family 25 (mitochondrial carrier; adenine nucleotide translocator), member 13, full insert sequence.
AK152237 - Mus musculus bone marrow macrophage cDNA, RIKEN full-length enriched library, clone:I830057F15 product:solute carrier family 25 (mitochondrial carrier; adenine nucleotide translocator), member 13, full insert sequence.
AF164632 - Mus musculus citrin (Slc25a13) mRNA, complete cds.
AK150496 - Mus musculus bone marrow macrophage cDNA, RIKEN full-length enriched library, clone:I830008K02 product:solute carrier family 25 (mitochondrial carrier; adenine nucleotide translocator), member 13, full insert sequence.
AK002829 - Mus musculus adult male kidney cDNA, RIKEN full-length enriched library, clone:0610039E03 product:solute carrier family 25 (mitochondrial carrier; adenine nucleotide translocator), member 13, full insert sequence.
AK029020 - Mus musculus 10 days neonate skin cDNA, RIKEN full-length enriched library, clone:4732482D23 product:solute carrier family 25 (mitochondrial carrier; adenine nucleotide translocator), member 13, full insert sequence.
AK012670 - Mus musculus 10, 11 days embryo whole body cDNA, RIKEN full-length enriched library, clone:2810004F14 product:solute carrier family 25 (mitochondrial carrier; adenine nucleotide translocator), member 13, full insert sequence.
BC016571 - Mus musculus solute carrier family 25 (mitochondrial carrier, adenine nucleotide translocator), member 13, mRNA (cDNA clone MGC:29043 IMAGE:3600909), complete cds.
AK199748 - Mus musculus cDNA, clone:Y1G0132E09, strand:minus, reference:ENSEMBL:Mouse-Transcript-ENST:ENSMUST00000015256, based on BLAT search.
AK190917 - Mus musculus cDNA, clone:Y1G0104D21, strand:minus, reference:ENSEMBL:Mouse-Transcript-ENST:ENSMUST00000015256, based on BLAT search.
AK181627 - Mus musculus cDNA, clone:Y0G0118N13, strand:minus, reference:ENSEMBL:Mouse-Transcript-ENST:ENSMUST00000015256, based on BLAT search.

-  Biochemical and Signaling Pathways
  Reactome (by CSHL, EBI, and GO)

Protein Q9QXX4 (Reactome details) participates in the following event(s):

R-MMU-372448 SLC25A12,13 exchange cytosolic L-Glu for mitochondrial matrix L-Asp
R-MMU-70263 Gluconeogenesis
R-MMU-70326 Glucose metabolism
R-MMU-71387 Metabolism of carbohydrates
R-MMU-1430728 Metabolism

-  Other Names for This Gene
  Alternate Gene Symbols: AK012670, AK029020, AK151180, AK152237, Aralar2, NM_015829
UCSC ID: AK150496
RefSeq Accession: NM_015829
Protein: Q9QXX4 (aka CMC2_MOUSE)

-  Methods, Credits, and Use Restrictions
  Click here for details on how this gene model was made and data restrictions if any.