Mouse Gene Denr (ENSMUST00000023869.14) Description and Page Index
  Description: Mus musculus density-regulated protein (Denr), mRNA. (from RefSeq NM_026603)
Gencode Transcript: ENSMUST00000023869.14
Gencode Gene: ENSMUSG00000023106.15
Transcript (Including UTRs)
   Position: mm10 chr5:123,907,175-123,928,835 Size: 21,661 Total Exon Count: 8 Strand: +
Coding Region
   Position: mm10 chr5:123,908,109-123,927,294 Size: 19,186 Coding Exon Count: 7 

Page IndexSequence and LinksUniProtKB CommentsCTDRNA StructureProtein Structure
Other SpeciesGO AnnotationsmRNA DescriptionsOther NamesModel InformationMethods
Data last updated: 2019-09-19

-  Sequence and Links to Tools and Databases
Genomic Sequence (chr5:123,907,175-123,928,835)mRNA (may differ from genome)Protein (198 aa)
Gene SorterGenome BrowserOther Species FASTAVisiGeneTable SchemaBioGPS
CGAPEnsemblEntrez GeneExonPrimerGeneCardsMGI
PubMedStanford SOURCEUniProtKBWikipedia

-  Comments and Description Text from UniProtKB
DESCRIPTION: RecName: Full=Density-regulated protein; Short=DRP;
FUNCTION: May be involved in the translation of target mRNAs by scanning and recognition of the initiation codon (By similarity).
SUBUNIT: Interacts with MCTS1 (By similarity).
SIMILARITY: Belongs to the DENR family.
SIMILARITY: Contains 1 SUI1 domain.

-  Comparative Toxicogenomics Database (CTD)
  The following chemicals interact with this gene           more ... click here to view the complete list

-  mRNA Secondary Structure of 3' and 5' UTRs
RegionFold EnergyBasesEnergy/Base
Display As
5' UTR -94.50201-0.470 Picture PostScript Text
3' UTR -428.101541-0.278 Picture PostScript Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

-  Protein Domain and Structure Information
  InterPro Domains: Graphical view of domain structure
IPR005873 - Drp1
IPR001950 - TIF_SUI1

Pfam Domains:
PF01253 - Translation initiation factor SUI1

SCOP Domains:
52833 - Thioredoxin-like
55159 - eIF1-like

ModBase Predicted Comparative 3D Structure on Q9CQJ6
The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.

-  Orthologous Genes in Other Species
  Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
HumanRatZebrafishD. melanogasterC. elegansS. cerevisiae
Genome BrowserGenome BrowserNo orthologGenome BrowserGenome BrowserNo ortholog
Gene Details    Gene Details
Gene Sorter    Gene Sorter
Protein SequenceProtein Sequence Protein SequenceProtein Sequence 
AlignmentAlignment AlignmentAlignment 

-  Gene Ontology (GO) Annotations with Structured Vocabulary
  Molecular Function:
GO:0003729 mRNA binding
GO:0003743 translation initiation factor activity
GO:0043022 ribosome binding

Biological Process:
GO:0001731 formation of translation preinitiation complex
GO:0002188 translation reinitiation
GO:0002192 IRES-dependent translational initiation
GO:0006412 translation
GO:0006413 translational initiation
GO:0032790 ribosome disassembly
GO:0075522 IRES-dependent viral translational initiation

Cellular Component:
GO:0070992 translation initiation complex
GO:0005840 ribosome

-  Descriptions from all associated GenBank mRNAs
  AK135127 - Mus musculus 10 days neonate cerebellum cDNA, RIKEN full-length enriched library, clone:6530401I17 product:density-regulated protein, full insert sequence.
AK017647 - Mus musculus 8 days embryo whole body cDNA, RIKEN full-length enriched library, clone:5730448F22 product:DENSITY-REGULATED PROTEIN (DRP), full insert sequence.
AK010394 - Mus musculus ES cells cDNA, RIKEN full-length enriched library, clone:2410004J11 product:DENSITY-REGULATED PROTEIN (DRP) homolog [Mus musculus], full insert sequence.
AK083852 - Mus musculus 12 days embryo spinal ganglion cDNA, RIKEN full-length enriched library, clone:D130023H04 product:similar to DENSITY-REGULATED PROTEIN (DRP) [Mus musculus], full insert sequence.
AK018762 - Mus musculus adult male cerebellum cDNA, RIKEN full-length enriched library, clone:1500003K04 product:DENSITY-REGULATED PROTEIN (DRP) homolog [Mus musculus], full insert sequence.
BC025143 - Mus musculus cDNA clone IMAGE:2812402, containing frame-shift errors.
BC043922 - Mus musculus density-regulated protein, mRNA (cDNA clone MGC:46763 IMAGE:5373203), complete cds.
DQ558604 - Mus musculus piRNA piR-25716, complete sequence.

-  Other Names for This Gene
  Alternate Gene Symbols: DENR_MOUSE, NM_026603, Q3UXY1, Q9CQJ6, uc008zor.1, uc008zor.2
UCSC ID: uc008zor.2
RefSeq Accession: NM_026603
Protein: Q9CQJ6 (aka DENR_MOUSE)
CCDS: CCDS39275.1

-  Gene Model Information
  Click here for a detailed description of the fields of the table above.

-  Methods, Credits, and Use Restrictions
  Click here for details on how this gene model was made and data restrictions if any.