Mouse Gene Eif5b (ENSMUST00000027252.7) Description and Page Index
  Description: Mus musculus eukaryotic translation initiation factor 5B (Eif5b), mRNA. (from RefSeq NM_198303)
Gencode Transcript: ENSMUST00000027252.7
Gencode Gene: ENSMUSG00000026083.12
Transcript (Including UTRs)
   Position: mm10 chr1:37,998,010-38,055,579 Size: 57,570 Total Exon Count: 24 Strand: +
Coding Region
   Position: mm10 chr1:37,998,290-38,051,713 Size: 53,424 Coding Exon Count: 24 

Page IndexSequence and LinksUniProtKB CommentsCTDRNA StructureProtein Structure
Other SpeciesGO AnnotationsmRNA DescriptionsPathwaysOther NamesModel Information
Methods
Data last updated: 2019-09-19

-  Sequence and Links to Tools and Databases
 
Genomic Sequence (chr1:37,998,010-38,055,579)mRNA (may differ from genome)Protein (1216 aa)
Gene SorterGenome BrowserOther Species FASTAVisiGeneTable SchemaBioGPS
CGAPEnsemblEntrez GeneExonPrimerGeneCardsMGI
PubMedStanford SOURCEUniProtKBWikipedia

-  Comments and Description Text from UniProtKB
  ID: IF2P_MOUSE
DESCRIPTION: RecName: Full=Eukaryotic translation initiation factor 5B; Short=eIF-5B; AltName: Full=Translation initiation factor IF-2;
FUNCTION: Function in general translation initiation by promoting the binding of the formylmethionine-tRNA to ribosomes. Seems to function along with eIF-2 (By similarity).
SUBUNIT: Interacts with ANXA5 in a calcium and phospholipid- dependent manner (By similarity).
SUBCELLULAR LOCATION: Cytoplasm.
SIMILARITY: Belongs to the IF-2 family.
SEQUENCE CAUTION: Sequence=AAH18347.1; Type=Miscellaneous discrepancy; Note=Contaminating sequence. Potential poly-A sequence; Sequence=AAH37150.1; Type=Miscellaneous discrepancy; Note=Contaminating sequence. Potential poly-A sequence; Sequence=AAH40746.1; Type=Miscellaneous discrepancy; Note=Contaminating sequence. Potential poly-A sequence; Sequence=AAH60288.1; Type=Miscellaneous discrepancy; Note=Contaminating sequence. Potential poly-A sequence;

-  Comparative Toxicogenomics Database (CTD)
  The following chemicals interact with this gene           more ... click here to view the complete list

-  mRNA Secondary Structure of 3' and 5' UTRs
 
RegionFold EnergyBasesEnergy/Base
Display As
5' UTR -138.00280-0.493 Picture PostScript Text
3' UTR -1083.903866-0.280 Picture PostScript Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

-  Protein Domain and Structure Information
  InterPro Domains: Graphical view of domain structure
IPR000795 - ProtSyn_GTP-bd
IPR005225 - Small_GTP-bd_dom
IPR015760 - TIF_IF2
IPR023115 - TIF_IF2_dom3
IPR004161 - Transl_elong_EFTu/EF1A_2
IPR009000 - Transl_elong_init/rib_B-barrel

Pfam Domains:
PF00009 - Elongation factor Tu GTP binding domain
PF01926 - 50S ribosome-binding GTPase
PF03144 - Elongation factor Tu domain 2
PF11987 - Translation-initiation factor 2

SCOP Domains:
50447 - Translation proteins
52156 - Initiation factor IF2/eIF5b, domain 3
52540 - P-loop containing nucleoside triphosphate hydrolases

ModBase Predicted Comparative 3D Structure on Q05D44
FrontTopSide
The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.

-  Orthologous Genes in Other Species
  Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
HumanRatZebrafishD. melanogasterC. elegansS. cerevisiae
Genome BrowserNo orthologNo orthologGenome BrowserGenome BrowserNo ortholog
Gene Details    Gene Details
Gene Sorter    Gene Sorter
GenBank EnsemblEnsemblWormBaseSGD
Protein Sequence  Protein SequenceProtein Sequence 
Alignment  AlignmentAlignment 

-  Gene Ontology (GO) Annotations with Structured Vocabulary
  Molecular Function:
GO:0000166 nucleotide binding
GO:0003743 translation initiation factor activity
GO:0003924 GTPase activity
GO:0005525 GTP binding
GO:0016787 hydrolase activity
GO:0046872 metal ion binding

Biological Process:
GO:0006412 translation
GO:0006413 translational initiation
GO:0006446 regulation of translational initiation

Cellular Component:
GO:0005737 cytoplasm


-  Descriptions from all associated GenBank mRNAs
  AK145732 - Mus musculus blastocyst blastocyst cDNA, RIKEN full-length enriched library, clone:I1C0034P13 product:Similar to translation initiation factor IF2 (Fragment) homolog [Mus musculus], full insert sequence.
AK163527 - Mus musculus adult male corpora quadrigemina cDNA, RIKEN full-length enriched library, clone:B230344F22 product:Similar to translation initiation factor IF2 (Fragment) homolog [Mus musculus], full insert sequence.
AK145146 - Mus musculus mammary gland RCB-0527 Jyg-MC(B) cDNA, RIKEN full-length enriched library, clone:G930003I10 product:Similar to translation initiation factor IF2 (Fragment) homolog [Mus musculus], full insert sequence.
BC103806 - Mus musculus eukaryotic translation initiation factor 5B, mRNA (cDNA clone IMAGE:30121910), with apparent retained intron.
AK168377 - Mus musculus 17 days embryo kidney cDNA, RIKEN full-length enriched library, clone:I920005B08 product:similar to Translation initiation factor IF-2 [Homo sapiens], full insert sequence.
BC040746 - Mus musculus eukaryotic translation initiation factor 5B, mRNA (cDNA clone IMAGE:3498498), partial cds.
BC018347 - Mus musculus eukaryotic translation initiation factor 5B, mRNA (cDNA clone IMAGE:3584181), partial cds.
BC060288 - Mus musculus eukaryotic translation initiation factor 5B, mRNA (cDNA clone IMAGE:6517770), partial cds.
BC037150 - Mus musculus eukaryotic translation initiation factor 5B, mRNA (cDNA clone IMAGE:5148558), partial cds.
BC166034 - Synthetic construct Mus musculus clone IMAGE:100066334, MGC:195471 eukaryotic translation initiation factor 5B (Eif5b) mRNA, encodes complete protein.
AK162176 - Mus musculus in vitro fertilized eggs cDNA, RIKEN full-length enriched library, clone:7420445P15 product:similar to Translation initiation factor IF2 [Homo sapiens], full insert sequence.
BC023025 - Mus musculus eukaryotic translation initiation factor 5B, mRNA (cDNA clone IMAGE:5362343).
AK135888 - Mus musculus in vitro fertilized eggs cDNA, RIKEN full-length enriched library, clone:7420433F08 product:PC4 and SFRS1 interacting protein 1, full insert sequence.
AK037164 - Mus musculus 6 days neonate skin cDNA, RIKEN full-length enriched library, clone:A030003E17 product:TRANSLATION INITIATION FACTOR IF-2 homolog [Homo sapiens], full insert sequence.
BC055393 - Mus musculus eukaryotic translation initiation factor 5B, mRNA (cDNA clone IMAGE:5690155), complete cds.
AK173016 - Mus musculus mRNA for mKIAA0741 protein.
AK037432 - Mus musculus 16 days neonate thymus cDNA, RIKEN full-length enriched library, clone:A130018I12 product:translation initiation factor IF-2 homolog (fragment) homolog [Homo sapiens], full insert sequence.
AK136813 - Mus musculus adult male diencephalon cDNA, RIKEN full-length enriched library, clone:9330022K11 product:unclassifiable, full insert sequence.

-  Biochemical and Signaling Pathways
  KEGG - Kyoto Encyclopedia of Genes and Genomes
mmu03013 - RNA transport

-  Other Names for This Gene
  Alternate Gene Symbols: If2, IF2P_MOUSE, NM_198303, Q05D44, Q3SYI4, Q3TQJ8, Q3UL37, Q3UM39, Q6PAI0, Q8CFF4, Q8CGD6, uc007aso.1
UCSC ID: uc007aso.1
RefSeq Accession: NM_198303
Protein: Q05D44 (aka IF2P_MOUSE)
CCDS: CCDS35544.1

-  Gene Model Information
  Click here for a detailed description of the fields of the table above.

-  Methods, Credits, and Use Restrictions
  Click here for details on how this gene model was made and data restrictions if any.