Mouse Gene Elp1 (ENSMUST00000030140.2) Description and Page Index
  Description: Mus musculus elongator complex protein 1 (Elp1), mRNA. (from RefSeq NM_026079)
Gencode Transcript: ENSMUST00000030140.2
Gencode Gene: ENSMUSG00000028431.11
Transcript (Including UTRs)
   Position: mm10 chr4:56,749,680-56,802,331 Size: 52,652 Total Exon Count: 37 Strand: -
Coding Region
   Position: mm10 chr4:56,751,652-56,800,124 Size: 48,473 Coding Exon Count: 36 

Page IndexSequence and LinksUniProtKB CommentsRNA StructureProtein StructureOther Species
GO AnnotationsmRNA DescriptionsPathwaysOther NamesModel InformationMethods
Data last updated: 2019-09-19

-  Sequence and Links to Tools and Databases
 
Genomic Sequence (chr4:56,749,680-56,802,331)mRNA (may differ from genome)Protein (1333 aa)
Gene SorterGenome BrowserOther Species FASTAVisiGeneTable SchemaBioGPS
CGAPEnsemblEntrez GeneExonPrimerGeneCardsMGI
PubMedStanford SOURCEUniProtKB

-  Comments and Description Text from UniProtKB
  ID: ELP1_MOUSE
DESCRIPTION: RecName: Full=Elongator complex protein 1; Short=ELP1; AltName: Full=IkappaB kinase complex-associated protein; Short=IKK complex-associated protein;
FUNCTION: May act as a scaffold protein that may assemble active IKK-MAP3K14 complexes (IKKA, IKKB and MAP3K14/NIK) (By similarity).
FUNCTION: Acts as subunit of the RNA polymerase II elongator complex, which is a histone acetyltransferase component of the RNA polymerase II (Pol II) holoenzyme and is involved in transcriptional elongation. Elongator may play a role in chromatin remodeling and is involved in acetylation of histones H3 and probably H4. Involved in cell migration.
SUBUNIT: Interacts preferentially with MAP3K14/NIK followed by IKK-alpha and IKK-beta. Component of the RNA polymerase II elongator complex (Elongator), which consists of IKBKAP/ELP1, STIP1/ELP2, ELP3, ELP4, ELP5 and ELP6. Elongator associates with the C-terminal domain (CTD) of Pol II largest subunit. Interacts with ELP3 (By similarity).
SUBCELLULAR LOCATION: Cytoplasm (By similarity). Nucleus (By similarity).
TISSUE SPECIFICITY: Widely expressed with highest levels in brain.
DEVELOPMENTAL STAGE: Expressed at embryonic days 7, 11, 15 and 17 with the highest expression at embryonic day 11.
PTM: Phosphorylated (By similarity).
SIMILARITY: Belongs to the ELP1/IKA1 family.
SEQUENCE CAUTION: Sequence=AAL36025.1; Type=Frameshift; Positions=498; Sequence=AAO15309.1; Type=Frameshift; Positions=Several;

-  mRNA Secondary Structure of 3' and 5' UTRs
 
RegionFold EnergyBasesEnergy/Base
Display As
5' UTR -71.50186-0.384 Picture PostScript Text
3' UTR -598.701972-0.304 Picture PostScript Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

-  Protein Domain and Structure Information
  InterPro Domains: Graphical view of domain structure
IPR011042 - 6-blade_b-propeller_TolB-like
IPR006849 - IKI3

Pfam Domains:
PF04762 - IKI3 family

SCOP Domains:
101478 - ADP-ribosylglycohydrolase
50952 - Soluble quinoprotein glucose dehydrogenase
50960 - TolB, C-terminal domain
63825 - YWTD domain
63829 - Calcium-dependent phosphotriesterase
69304 - Tricorn protease N-terminal domain
101898 - NHL repeat
101908 - Putative isomerase YbhE
117289 - Nucleoporin domain
50969 - YVTN repeat-like/Quinoprotein amine dehydrogenase
50974 - Nitrous oxide reductase, N-terminal domain
50978 - WD40 repeat-like
50993 - Peptidase/esterase 'gauge' domain
69322 - Tricorn protease domain 2
50998 - Quinoprotein alcohol dehydrogenase-like
51004 - C-terminal (heme d1) domain of cytochrome cd1-nitrite reductase
82171 - DPP6 N-terminal domain-like

ModBase Predicted Comparative 3D Structure on Q7TT37
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The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.

-  Orthologous Genes in Other Species
  Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
HumanRatZebrafishD. melanogasterC. elegansS. cerevisiae
Genome BrowserGenome BrowserNo orthologGenome BrowserGenome BrowserNo ortholog
Gene Details    Gene Details
Gene Sorter    Gene Sorter
GenBankRGDEnsemblEnsemblWormBaseSGD
Protein SequenceProtein Sequence Protein SequenceProtein Sequence 
AlignmentAlignment AlignmentAlignment 

-  Gene Ontology (GO) Annotations with Structured Vocabulary
  Molecular Function:
GO:0000993 RNA polymerase II core binding
GO:0004672 protein kinase activity
GO:0005524 ATP binding
GO:0008607 phosphorylase kinase regulator activity

Biological Process:
GO:0002098 tRNA wobble uridine modification
GO:0006351 transcription, DNA-templated
GO:0006355 regulation of transcription, DNA-templated
GO:0006357 regulation of transcription from RNA polymerase II promoter
GO:0007252 I-kappaB phosphorylation
GO:0030335 positive regulation of cell migration
GO:0045859 regulation of protein kinase activity

Cellular Component:
GO:0000123 histone acetyltransferase complex
GO:0005634 nucleus
GO:0005730 nucleolus
GO:0005737 cytoplasm
GO:0005829 cytosol
GO:0008023 transcription elongation factor complex
GO:0033588 Elongator holoenzyme complex


-  Descriptions from all associated GenBank mRNAs
  LF194409 - JP 2014500723-A/1912: Polycomb-Associated Non-Coding RNAs.
AK076152 - Mus musculus 13 days embryo head cDNA, RIKEN full-length enriched library, clone:3110040G09 product:inhibitor of kappa light polypeptide enhancer in B-cells, kinase complex-associated protein, full insert sequence.
AK032563 - Mus musculus adult male olfactory brain cDNA, RIKEN full-length enriched library, clone:6430596J03 product:inhibitor of kappa light polypeptide enhancer in B-cells, kinase complex-associated protein, full insert sequence.
AF140786 - Mus musculus IKK-complex-associated protein IKAP mRNA, complete cds.
AF387811 - Mus musculus IKAP (Ikbkap) mRNA, complete cds.
AK165168 - Mus musculus 8 cells embryo 8 cells cDNA, RIKEN full-length enriched library, clone:E860020G14 product:inhibitor of kappa light polypeptide enhancer in B-cells, kinase complex-associated protein, full insert sequence.
AK147153 - Mus musculus cDNA, RIKEN full-length enriched library, clone:I920190L24 product:inhibitor of kappa light polypeptide enhancer in B-cells, kinase complex-associated protein, full insert sequence.
BC052387 - Mus musculus inhibitor of kappa light polypeptide enhancer in B-cells, kinase complex-associated protein, mRNA (cDNA clone MGC:64628 IMAGE:5705589), complete cds.
AK004402 - Mus musculus 18-day embryo whole body cDNA, RIKEN full-length enriched library, clone:1110067O14 product:inhibitor of kappa light polypeptide enhancer in B-cells, kinase complex-associated protein, full insert sequence.
AK170341 - Mus musculus NOD-derived CD11c +ve dendritic cells cDNA, RIKEN full-length enriched library, clone:F630048P22 product:inhibitor of kappa light polypeptide enhancer in B-cells, kinase complex-associated protein, full insert sequence.
BC054468 - Mus musculus inhibitor of kappa light polypeptide enhancer in B-cells, kinase complex-associated protein, mRNA (cDNA clone IMAGE:4501529), complete cds.
AF367244 - Mus musculus Ikap (Ikbkap) mRNA, complete cds.
AK031367 - Mus musculus 13 days embryo male testis cDNA, RIKEN full-length enriched library, clone:6030413P05 product:inhibitor of kappa light polypeptide enhancer in B-cells, kinase complex-associated protein, full insert sequence.
BC035529 - Mus musculus inhibitor of kappa light polypeptide enhancer in B-cells, kinase complex-associated protein, mRNA (cDNA clone IMAGE:5365773).
AK171496 - Mus musculus B6-derived CD11 +ve dendritic cells cDNA, RIKEN full-length enriched library, clone:F730222D22 product:inhibitor of kappa light polypeptide enhancer in B-cells, kinase complex-associated protein, full insert sequence.
MA429986 - JP 2018138019-A/1912: Polycomb-Associated Non-Coding RNAs.
LF271922 - JP 2014500723-A/79425: Polycomb-Associated Non-Coding RNAs.
LF271923 - JP 2014500723-A/79426: Polycomb-Associated Non-Coding RNAs.
LF271924 - JP 2014500723-A/79427: Polycomb-Associated Non-Coding RNAs.
LF271925 - JP 2014500723-A/79428: Polycomb-Associated Non-Coding RNAs.
MA507499 - JP 2018138019-A/79425: Polycomb-Associated Non-Coding RNAs.
MA507500 - JP 2018138019-A/79426: Polycomb-Associated Non-Coding RNAs.
MA507501 - JP 2018138019-A/79427: Polycomb-Associated Non-Coding RNAs.
MA507502 - JP 2018138019-A/79428: Polycomb-Associated Non-Coding RNAs.
LF271926 - JP 2014500723-A/79429: Polycomb-Associated Non-Coding RNAs.
AK035944 - Mus musculus 16 days neonate cerebellum cDNA, RIKEN full-length enriched library, clone:9630020C07 product:inhibitor of kappa light polypeptide enhancer in B-cells, kinase complex-associated protein, full insert sequence.
LF271936 - JP 2014500723-A/79439: Polycomb-Associated Non-Coding RNAs.
LF271937 - JP 2014500723-A/79440: Polycomb-Associated Non-Coding RNAs.
LF271944 - JP 2014500723-A/79447: Polycomb-Associated Non-Coding RNAs.
LF271945 - JP 2014500723-A/79448: Polycomb-Associated Non-Coding RNAs.
LF271947 - JP 2014500723-A/79450: Polycomb-Associated Non-Coding RNAs.
DQ715818 - Mus musculus piRNA piR-131140, complete sequence.
AK196177 - Mus musculus cDNA, clone:Y1G0121A15, strand:minus, reference:ENSEMBL:Mouse-Transcript-ENST:ENSMUST00000030140, based on BLAT search.
LF271949 - JP 2014500723-A/79452: Polycomb-Associated Non-Coding RNAs.
LF271950 - JP 2014500723-A/79453: Polycomb-Associated Non-Coding RNAs.
LF271951 - JP 2014500723-A/79454: Polycomb-Associated Non-Coding RNAs.
LF271965 - JP 2014500723-A/79468: Polycomb-Associated Non-Coding RNAs.
LF271966 - JP 2014500723-A/79469: Polycomb-Associated Non-Coding RNAs.
LF271969 - JP 2014500723-A/79472: Polycomb-Associated Non-Coding RNAs.
LF271972 - JP 2014500723-A/79475: Polycomb-Associated Non-Coding RNAs.
AK031157 - Mus musculus 13 days embryo forelimb cDNA, RIKEN full-length enriched library, clone:5930418C13 product:inhibitor of kappa light polypeptide enhancer in B-cells, kinase complex-associated protein, full insert sequence.
MA507503 - JP 2018138019-A/79429: Polycomb-Associated Non-Coding RNAs.
MA507513 - JP 2018138019-A/79439: Polycomb-Associated Non-Coding RNAs.
MA507514 - JP 2018138019-A/79440: Polycomb-Associated Non-Coding RNAs.
MA507521 - JP 2018138019-A/79447: Polycomb-Associated Non-Coding RNAs.
MA507522 - JP 2018138019-A/79448: Polycomb-Associated Non-Coding RNAs.
MA507524 - JP 2018138019-A/79450: Polycomb-Associated Non-Coding RNAs.
MA507526 - JP 2018138019-A/79452: Polycomb-Associated Non-Coding RNAs.
MA507527 - JP 2018138019-A/79453: Polycomb-Associated Non-Coding RNAs.
MA507528 - JP 2018138019-A/79454: Polycomb-Associated Non-Coding RNAs.
MA507542 - JP 2018138019-A/79468: Polycomb-Associated Non-Coding RNAs.
MA507543 - JP 2018138019-A/79469: Polycomb-Associated Non-Coding RNAs.
MA507546 - JP 2018138019-A/79472: Polycomb-Associated Non-Coding RNAs.
MA507549 - JP 2018138019-A/79475: Polycomb-Associated Non-Coding RNAs.

-  Biochemical and Signaling Pathways
  BioCarta from NCI Cancer Genome Anatomy Project
m_tnfr2Pathway - TNFR2 Signaling Pathway

-  Other Names for This Gene
  Alternate Gene Symbols: ELP1_MOUSE, Ikap, Ikbkap, NM_026079, Q3UHY6, Q7TQH1, Q7TT37, Q8C6B3, Q8CBI3, Q8CH82, Q8VHU5, Q8VHV9, Q9CT81, uc012del.1
UCSC ID: uc012del.1
RefSeq Accession: NM_026079
Protein: Q7TT37 (aka ELP1_MOUSE)
CCDS: CCDS38765.1

-  Gene Model Information
  Click here for a detailed description of the fields of the table above.

-  Methods, Credits, and Use Restrictions
  Click here for details on how this gene model was made and data restrictions if any.