Mouse Gene Mfrp (ENSMUST00000034654.8) Description and Page Index
  Description: Mus musculus membrane frizzled-related protein (Mfrp), transcript variant 1, mRNA. (from RefSeq NM_147126)
RefSeq Summary (NM_147126): The protein encoded by this gene contains a region with similarity to the cysteine-rich domain (CRD) of frizzled, a gene originally found in Drosophila that controls tissue polarity. This protein functions in eye development, where it is necessary for the maintenance of photoreceptor outer segments. Mutations in this gene cause retinal degeneration 6 in mice, which gives rise to a mouse model for human retinitis punctata albescens. Bicistronic transcripts composed of the coding sequences for this gene (Mfrp) and the C1q and tumor necrosis factor related protein 5 gene (C1qtnf5) have been identified, and the resulting products can interact with each other. Co-transcription of C1qtnf5 and Mfrp has been observed in both human and mouse. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jun 2010].
Gencode Transcript: ENSMUST00000034654.8
Gencode Gene: ENSMUSG00000034739.17
Transcript (Including UTRs)
   Position: mm10 chr9:44,101,729-44,109,187 Size: 7,459 Total Exon Count: 14 Strand: +
Coding Region
   Position: mm10 chr9:44,101,893-44,106,467 Size: 4,575 Coding Exon Count: 13 

Page IndexSequence and LinksUniProtKB CommentsCTDRNA StructureProtein Structure
Other SpeciesGO AnnotationsmRNA DescriptionsOther NamesModel InformationMethods
Data last updated: 2019-09-19

-  Sequence and Links to Tools and Databases
Genomic Sequence (chr9:44,101,729-44,109,187)mRNA (may differ from genome)Protein (584 aa)
Gene SorterGenome BrowserOther Species FASTAVisiGeneTable SchemaBioGPS
CGAPEnsemblEntrez GeneExonPrimerGeneCardsMGI
PubMedStanford SOURCEUniProtKBWikipedia

-  Comments and Description Text from UniProtKB
DESCRIPTION: RecName: Full=Membrane frizzled-related protein; AltName: Full=Membrane-type frizzled-related protein;
FUNCTION: May play a role in eye development.
SUBCELLULAR LOCATION: Membrane; Single-pass type II membrane protein (Potential).
TISSUE SPECIFICITY: Expressed in retinal pigment epithelium and ciliary epithelium of the eye.
DISEASE: Note=Defects in Mfrp are the cause of retinal degeneration 6 (RD6). RD6 is an autosomal recessive degeneration of the photoreceptors causing dysfunction of both rods and cones.
SIMILARITY: Contains 2 CUB domains.
SIMILARITY: Contains 1 FZ (frizzled) domain.
SIMILARITY: Contains 2 LDL-receptor class A domains.

-  Comparative Toxicogenomics Database (CTD)
  The following chemicals interact with this gene

-  mRNA Secondary Structure of 3' and 5' UTRs
RegionFold EnergyBasesEnergy/Base
Display As
5' UTR -60.70164-0.370 Picture PostScript Text
3' UTR -988.502397-0.412 Picture PostScript Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

-  Protein Domain and Structure Information
  InterPro Domains: Graphical view of domain structure
IPR000859 - CUB
IPR020067 - Frizzled_dom
IPR023415 - LDLR_class-A_CS
IPR002172 - LDrepeatLR_classA_rpt

Pfam Domains:
PF00057 - Low-density lipoprotein receptor domain class A
PF00431 - CUB domain
PF01392 - Fz domain

SCOP Domains:
63501 - Frizzled cysteine-rich domain
49854 - Spermadhesin, CUB domain
57424 - LDL receptor-like module

ModBase Predicted Comparative 3D Structure on Q8K480
The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.

-  Orthologous Genes in Other Species
  Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
HumanRatZebrafishD. melanogasterC. elegansS. cerevisiae
Genome BrowserGenome BrowserNo orthologNo orthologNo orthologNo ortholog
Gene Details     
Gene Sorter     
Protein SequenceProtein Sequence    

-  Gene Ontology (GO) Annotations with Structured Vocabulary
  Biological Process:
GO:0007601 visual perception
GO:0042462 eye photoreceptor cell development
GO:0060041 retina development in camera-type eye

Cellular Component:
GO:0005886 plasma membrane
GO:0016020 membrane
GO:0016021 integral component of membrane
GO:0016324 apical plasma membrane

-  Descriptions from all associated GenBank mRNAs
  BC153043 - Synthetic construct Mus musculus clone IMAGE:100016395, MGC:184528 membrane-type frizzled-related protein (Mfrp) mRNA, encodes complete protein.
AK053629 - Mus musculus 0 day neonate eyeball cDNA, RIKEN full-length enriched library, clone:E130116A14 product:weakly similar to membrane-type frizzled-related protein [Homo sapiens], full insert sequence.
AF469650 - Mus musculus membrane-type frizzled-related protein (Mfrp) and complement-c1q tumor necrosis factor-related protein (C1qtnf5) mRNAs, complete cds.
BC148451 - Synthetic construct Mus musculus clone IMAGE:100015390, MGC:183272 membrane-type frizzled-related protein (Mfrp) mRNA, encodes complete protein.
BC023068 - Mus musculus C1q and tumor necrosis factor related protein 5, mRNA (cDNA clone MGC:38635 IMAGE:5355789), complete cds.
DQ002398 - Mus musculus C1qTNF5 (C1qtnf5) mRNA, complete cds.
BC025174 - Mus musculus C1q and tumor necrosis factor related protein 5, mRNA (cDNA clone MGC:36714 IMAGE:3978387), complete cds.

-  Other Names for This Gene
  Alternate Gene Symbols: MFRP_MOUSE, NM_147126, Q8BPP4, Q8K480, uc009pbr.1, uc009pbr.2, uc009pbr.3
UCSC ID: uc009pbr.3
RefSeq Accession: NM_147126
Protein: Q8K480 (aka MFRP_MOUSE)
CCDS: CCDS40597.1, CCDS52776.1

-  Gene Model Information
  Click here for a detailed description of the fields of the table above.

-  Methods, Credits, and Use Restrictions
  Click here for details on how this gene model was made and data restrictions if any.