Mouse Gene Dnal1 (ENSMUST00000046340.8) Description and Page Index
  Description: Interacts with DNAH5 (By similarity). (from UniProt Q05A62)
Gencode Transcript: ENSMUST00000046340.8
Gencode Gene: ENSMUSG00000042523.12
Transcript (Including UTRs)
   Position: mm10 chr12:84,114,371-84,138,457 Size: 24,087 Total Exon Count: 8 Strand: +
Coding Region
   Position: mm10 chr12:84,124,550-84,138,394 Size: 13,845 Coding Exon Count: 6 

Page IndexSequence and LinksUniProtKB CommentsCTDRNA StructureProtein Structure
Other SpeciesGO AnnotationsmRNA DescriptionsPathwaysOther NamesModel Information
Data last updated: 2019-09-19

-  Sequence and Links to Tools and Databases
Genomic Sequence (chr12:84,114,371-84,138,457)mRNA (may differ from genome)Protein (151 aa)
Gene SorterGenome BrowserOther Species FASTATable SchemaBioGPSCGAP
EnsemblExonPrimerGeneCardsMGIPubMedStanford SOURCE

-  Comments and Description Text from UniProtKB
DESCRIPTION: RecName: Full=Dynein light chain 1, axonemal;
SUBUNIT: Interacts with DNAH5 (By similarity).
TISSUE SPECIFICITY: Expressed in the respiratory epithelium of the upper airways and the ependymal cells lining the brain ventricles.
SIMILARITY: Belongs to the dynein light chain LC1-type family.
SIMILARITY: Contains 4 LRR (leucine-rich) repeats.
SIMILARITY: Contains 1 LRRCT domain.
SEQUENCE CAUTION: Sequence=AAI25395.2; Type=Erroneous initiation;

-  Comparative Toxicogenomics Database (CTD)
  The following chemicals interact with this gene

-  mRNA Secondary Structure of 3' and 5' UTRs
RegionFold EnergyBasesEnergy/Base
Display As
5' UTR -53.00271-0.196 Picture PostScript Text
3' UTR -7.0063-0.111 Picture PostScript Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

-  Protein Domain and Structure Information
  InterPro Domains: Graphical view of domain structure
IPR001611 - Leu-rich_rpt
IPR025875 - Leu-rich_rpt_2_copies

SCOP Domains:
52047 - RNI-like
52058 - L domain-like
52075 - Outer arm dynein light chain 1

ModBase Predicted Comparative 3D Structure on Q05A62
The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.

-  Orthologous Genes in Other Species
  Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
HumanRatZebrafishD. melanogasterC. elegansS. cerevisiae
Genome BrowserGenome BrowserNo orthologNo orthologNo orthologNo ortholog
Gene Details     
Gene Sorter     
Protein SequenceProtein Sequence    

-  Gene Ontology (GO) Annotations with Structured Vocabulary
  Molecular Function:
GO:0003774 motor activity
GO:0043014 alpha-tubulin binding
GO:0045504 dynein heavy chain binding

Biological Process:
GO:0036158 outer dynein arm assembly

Cellular Component:
GO:0005737 cytoplasm
GO:0005856 cytoskeleton
GO:0005874 microtubule
GO:0030286 dynein complex
GO:0036157 outer dynein arm
GO:0042995 cell projection

-  Descriptions from all associated GenBank mRNAs
  AK005826 - Mus musculus adult male testis cDNA, RIKEN full-length enriched library, clone:1700010H15 product:weakly similar to OUTER ARM DYNEIN LIGHT CHAIN 2 [Anthocidaris crassispina], full insert sequence.
BC070454 - Mus musculus RIKEN cDNA 1700010H15 gene, mRNA (cDNA clone IMAGE:30620126).
BC125392 - Mus musculus dynein, axonemal, light chain 1, mRNA (cDNA clone MGC:159095 IMAGE:40129907), complete cds.
BC125394 - Mus musculus dynein, axonemal, light chain 1, mRNA (cDNA clone MGC:159097 IMAGE:40129909), complete cds.

-  Biochemical and Signaling Pathways
  KEGG - Kyoto Encyclopedia of Genes and Genomes
mmu05016 - Huntington's disease

-  Other Names for This Gene
  Alternate Gene Symbols: A0JLX1, AK005826, DNAL1_MOUSE, Dnalc1, Q05A62, Q9DAH9, uc007oek.1, uc007oek.2, uc007oek.3, uc007oek.4
UCSC ID: uc007oek.4
RefSeq Accession: NM_001346528
Protein: Q05A62 (aka DNAL1_MOUSE)
CCDS: CCDS83987.1

-  Gene Model Information
  Click here for a detailed description of the fields of the table above.

-  Methods, Credits, and Use Restrictions
  Click here for details on how this gene model was made and data restrictions if any.