Mouse Gene Eif4g3 (ENSMUST00000058133.9) Description and Page Index
  Description: Eif4g3 (from geneSymbol)
Gencode Transcript: ENSMUST00000058133.9
Gencode Gene: ENSMUSG00000028760.16
Transcript (Including UTRs)
   Position: mm10 chr4:137,993,022-138,116,244 Size: 123,223 Total Exon Count: 10 Strand: +
Coding Region
   Position: mm10 chr4:138,082,959-138,115,200 Size: 32,242 Coding Exon Count: 7 

Page IndexSequence and LinksCTDRNA StructureProtein StructureOther Species
GO AnnotationsmRNA DescriptionsPathwaysOther NamesModel InformationMethods
Data last updated: 2019-09-19

-  Sequence and Links to Tools and Databases
 
Genomic Sequence (chr4:137,993,022-138,116,244)mRNA (may differ from genome)Protein (235 aa)
Gene SorterGenome BrowserOther Species FASTAVisiGeneTable SchemaBioGPS
CGAPEnsemblExonPrimerGeneCardsMGIPubMed
ReactomeStanford SOURCEUniProtKBWikipedia

-  Comparative Toxicogenomics Database (CTD)
  The following chemicals interact with this gene           more ... click here to view the complete list

-  mRNA Secondary Structure of 3' and 5' UTRs
 
RegionFold EnergyBasesEnergy/Base
Display As
5' UTR -380.80911-0.418 Picture PostScript Text
3' UTR -336.101044-0.322 Picture PostScript Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

-  Protein Domain and Structure Information
  ModBase Predicted Comparative 3D Structure on Q8BQR8
FrontTopSide
The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.

-  Orthologous Genes in Other Species
  Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
HumanRatZebrafishD. melanogasterC. elegansS. cerevisiae
Genome BrowserGenome BrowserNo orthologNo orthologNo orthologNo ortholog
Gene Details     
Gene Sorter     
GenBankRGD    
Protein SequenceProtein Sequence    
AlignmentAlignment    

-  Gene Ontology (GO) Annotations with Structured Vocabulary
  Molecular Function:
GO:0000339 RNA cap binding
GO:0003743 translation initiation factor activity

Biological Process:
GO:0006413 translational initiation


-  Descriptions from all associated GenBank mRNAs
  AK019693 - Mus musculus adult male testis cDNA, RIKEN full-length enriched library, clone:4930523M17 product:similar to EIF4GII [Homo sapiens], full insert sequence.
AK054068 - Mus musculus 2 days pregnant adult female oviduct cDNA, RIKEN full-length enriched library, clone:E230016B04 product:EIF4GII homolog [Homo sapiens], full insert sequence.
BC072600 - Mus musculus eukaryotic translation initiation factor 4 gamma, 3, mRNA (cDNA clone MGC:99864 IMAGE:6410320), complete cds.
AK046639 - Mus musculus 4 days neonate male adipose cDNA, RIKEN full-length enriched library, clone:B430215E05 product:hypothetical protein, full insert sequence.
BC082549 - Mus musculus eukaryotic translation initiation factor 4 gamma, 3, mRNA (cDNA clone IMAGE:6856339).
BC079885 - Mus musculus eukaryotic translation initiation factor 4 gamma, 3, mRNA (cDNA clone IMAGE:6853600).
AK050887 - Mus musculus 9 days embryo whole body cDNA, RIKEN full-length enriched library, clone:D030030A06 product:inferred: eIF4GII {Homo sapiens}, full insert sequence.
EF410093 - Mus musculus Accn1/Eif4g3 trans-spliced mRNA sequence.

-  Biochemical and Signaling Pathways
  KEGG - Kyoto Encyclopedia of Genes and Genomes
mmu03013 - RNA transport
mmu05416 - Viral myocarditis

BioCarta from NCI Cancer Genome Anatomy Project
m_mTORPathway - mTOR Signaling Pathway
m_iresPathway - Internal Ribosome entry pathway

Reactome (by CSHL, EBI, and GO)

Protein Q8BQR8 (Reactome details) participates in the following event(s):

R-MMU-1678842 Competitive inhibition of translation initiation by ISGylated 4EHP
R-MMU-1169408 ISG15 antiviral mechanism
R-MMU-1169410 Antiviral mechanism by IFN-stimulated genes
R-MMU-913531 Interferon Signaling
R-MMU-1280215 Cytokine Signaling in Immune system
R-MMU-168256 Immune System

-  Other Names for This Gene
  Alternate Gene Symbols: AK046639, Q8BQR8, Q8BQR8_MOUSE, RP23-300N21.1-003, uc008vjx.1, uc008vjx.2, uc008vjx.3
UCSC ID: uc008vjx.3
RefSeq Accession: NM_001369131
Protein: Q8BQR8

-  Gene Model Information
  Click here for a detailed description of the fields of the table above.

-  Methods, Credits, and Use Restrictions
  Click here for details on how this gene model was made and data restrictions if any.