Mouse Gene Stk19 (ENSMUST00000077477.11) Description and Page Index
  Description: Mus musculus serine/threonine kinase 19 (Stk19), mRNA. (from RefSeq NM_019442)
Gencode Transcript: ENSMUST00000077477.11
Gencode Gene: ENSMUSG00000061207.11
Transcript (Including UTRs)
   Position: mm10 chr17:34,823,993-34,836,945 Size: 12,953 Total Exon Count: 7 Strand: -
Coding Region
   Position: mm10 chr17:34,824,279-34,836,876 Size: 12,598 Coding Exon Count: 7 

Page IndexSequence and LinksUniProtKB CommentsCTDRNA StructureProtein Structure
Other SpeciesGO AnnotationsmRNA DescriptionsOther NamesModel InformationMethods
Data last updated: 2019-09-19

-  Sequence and Links to Tools and Databases
 
Genomic Sequence (chr17:34,823,993-34,836,945)mRNA (may differ from genome)Protein (254 aa)
Gene SorterGenome BrowserOther Species FASTAVisiGeneTable SchemaBioGPS
CGAPEnsemblEntrez GeneExonPrimerGeneCardsMGI
PubMedStanford SOURCEUniProtKBWikipedia

-  Comments and Description Text from UniProtKB
  ID: STK19_MOUSE
DESCRIPTION: RecName: Full=Serine/threonine-protein kinase 19; EC=2.7.11.1; AltName: Full=Protein RP1;
FUNCTION: Seems to be a protein kinase (By similarity).
CATALYTIC ACTIVITY: ATP + a protein = ADP + a phosphoprotein.
COFACTOR: Divalent cations. Has a preference for manganese (By similarity).
SUBUNIT: The N-terminus interacts with BAG1 (By similarity).
SUBCELLULAR LOCATION: Nucleus (By similarity).
SIMILARITY: Belongs to the STK19 family.

-  Comparative Toxicogenomics Database (CTD)
  The following chemicals interact with this gene           more ... click here to view the complete list

-  mRNA Secondary Structure of 3' and 5' UTRs
 
RegionFold EnergyBasesEnergy/Base
Display As
5' UTR -25.2069-0.365 Picture PostScript Text
3' UTR -102.80286-0.359 Picture PostScript Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

-  Protein Domain and Structure Information
  InterPro Domains: Graphical view of domain structure
IPR018865 - Ser/Thr_kinase_19

Pfam Domains:
PF10494 - Serine-threonine protein kinase 19

ModBase Predicted Comparative 3D Structure on Q9JHN8
FrontTopSide
The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.

-  Orthologous Genes in Other Species
  Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
HumanRatZebrafishD. melanogasterC. elegansS. cerevisiae
No orthologNo orthologNo orthologNo orthologNo orthologNo ortholog
      
      
  Ensembl   
      
      

-  Gene Ontology (GO) Annotations with Structured Vocabulary
  Molecular Function:
GO:0000166 nucleotide binding
GO:0003674 molecular_function
GO:0004674 protein serine/threonine kinase activity
GO:0005524 ATP binding
GO:0016301 kinase activity
GO:0016740 transferase activity

Biological Process:
GO:0006468 protein phosphorylation
GO:0008150 biological_process
GO:0016310 phosphorylation

Cellular Component:
GO:0005634 nucleus
GO:0016607 nuclear speck


-  Descriptions from all associated GenBank mRNAs
  AF099934 - Mus musculus MHC class III protein RP1 (Rp1) mRNA, partial cds.
BC022681 - Mus musculus serine/threonine kinase 19, mRNA (cDNA clone MGC:31382 IMAGE:4240347), complete cds.
AK168865 - Mus musculus 16 days embryo heart cDNA, RIKEN full-length enriched library, clone:I920061M10 product:serine/threonine kinase 19, full insert sequence.
AK146739 - Mus musculus 16 days embryo heart cDNA, RIKEN full-length enriched library, clone:I920048K03 product:serine/threonine kinase 19, full insert sequence.
BC050852 - Mus musculus serine/threonine kinase 19, mRNA (cDNA clone IMAGE:6516612).
AK178261 - Mus musculus cDNA, clone:Y0G0106A14, strand:minus, reference:ENSEMBL:Mouse-Transcript-ENST:ENSMUST00000046450, based on BLAT search.
AK186580 - Mus musculus cDNA, clone:Y0G0137N24, strand:minus, reference:ENSEMBL:Mouse-Transcript-ENST:ENSMUST00000046450, based on BLAT search.
AK215314 - Mus musculus cDNA, clone:Y2G0134K09, strand:minus, reference:ENSEMBL:Mouse-Transcript-ENST:ENSMUST00000046450, based on BLAT search.
AK218509 - Mus musculus cDNA, clone:Y2G0145G16, strand:minus, reference:ENSEMBL:Mouse-Transcript-ENST:ENSMUST00000046450, based on BLAT search.

-  Other Names for This Gene
  Alternate Gene Symbols: NM_019442, O70347, Q9JHN8, Rp1, STK19_MOUSE, uc008cdq.1, uc008cdq.2
UCSC ID: uc008cdq.2
RefSeq Accession: NM_019442
Protein: Q9JHN8 (aka STK19_MOUSE)
CCDS: CCDS28659.1

-  Gene Model Information
  Click here for a detailed description of the fields of the table above.

-  Methods, Credits, and Use Restrictions
  Click here for details on how this gene model was made and data restrictions if any.