Mouse Gene C1qtnf5 (ENSMUST00000114821.8) Description and Page Index
  Description: Mus musculus C1q and tumor necrosis factor related protein 5 (C1qtnf5), transcript variant 1, mRNA. (from RefSeq NM_145613)
RefSeq Summary (NM_001190314): The protein encoded by this gene contains a region with similarity to the cysteine-rich domain (CRD) of frizzled, a gene originally found in Drosophila that controls tissue polarity. This protein functions in eye development, where it is necessary for the maintenance of photoreceptor outer segments. Mutations in this gene cause retinal degeneration 6 in mice, which gives rise to a mouse model for human retinitis punctata albescens. Bicistronic transcripts composed of the coding sequences for this gene (Mfrp) and the C1q and tumor necrosis factor related protein 5 gene (C1qtnf5) have been identified, and the resulting products can interact with each other. Co-transcription of C1qtnf5 and Mfrp has been observed in both human and mouse. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jun 2010].
Gencode Transcript: ENSMUST00000114821.8
Gencode Gene: ENSMUSG00000079592.9
Transcript (Including UTRs)
   Position: mm10 chr9:44,107,254-44,109,185 Size: 1,932 Total Exon Count: 3 Strand: +
Coding Region
   Position: mm10 chr9:44,107,758-44,108,812 Size: 1,055 Coding Exon Count: 2 

Page IndexSequence and LinksUniProtKB CommentsRNA StructureProtein StructureOther Species
GO AnnotationsmRNA DescriptionsOther NamesModel InformationMethods
Data last updated: 2019-09-19

-  Sequence and Links to Tools and Databases
Genomic Sequence (chr9:44,107,254-44,109,185)mRNA (may differ from genome)Protein (243 aa)
Gene SorterGenome BrowserOther Species FASTAVisiGeneTable SchemaBioGPS
CGAPEnsemblEntrez GeneExonPrimerGeneCardsMGI
PubMedStanford SOURCEUniProtKBWikipedia

-  Comments and Description Text from UniProtKB
DESCRIPTION: RecName: Full=Complement C1q tumor necrosis factor-related protein 5; Flags: Precursor;
SUBCELLULAR LOCATION: Secreted (Probable).
SIMILARITY: Contains 1 C1q domain.
SIMILARITY: Contains 1 collagen-like domain.

-  mRNA Secondary Structure of 3' and 5' UTRs
RegionFold EnergyBasesEnergy/Base
Display As
5' UTR -96.40260-0.371 Picture PostScript Text
3' UTR -138.00373-0.370 Picture PostScript Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

-  Protein Domain and Structure Information
  InterPro Domains: Graphical view of domain structure
IPR001073 - C1q
IPR008160 - Collagen
IPR008983 - Tumour_necrosis_fac-like

Pfam Domains:
PF00386 - C1q domain
PF01391 - Collagen triple helix repeat (20 copies)

SCOP Domains:
49842 - TNF-like

ModBase Predicted Comparative 3D Structure on Q8K479
The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.

-  Orthologous Genes in Other Species
  Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
HumanRatZebrafishD. melanogasterC. elegansS. cerevisiae
Genome BrowserGenome BrowserNo orthologNo orthologNo orthologNo ortholog
Gene Details     
Gene Sorter     
Protein SequenceProtein Sequence    

-  Gene Ontology (GO) Annotations with Structured Vocabulary
  Molecular Function:
GO:0042802 identical protein binding

Biological Process:
GO:0009306 protein secretion
GO:0048839 inner ear development
GO:0070206 protein trimerization

Cellular Component:
GO:0005576 extracellular region
GO:0005581 collagen trimer
GO:0005615 extracellular space
GO:0005886 plasma membrane
GO:0005923 bicellular tight junction
GO:0016020 membrane
GO:0016324 apical plasma membrane
GO:0016328 lateral plasma membrane
GO:0030133 transport vesicle
GO:0042995 cell projection

-  Descriptions from all associated GenBank mRNAs
  AK053629 - Mus musculus 0 day neonate eyeball cDNA, RIKEN full-length enriched library, clone:E130116A14 product:weakly similar to membrane-type frizzled-related protein [Homo sapiens], full insert sequence.
AF469650 - Mus musculus membrane-type frizzled-related protein (Mfrp) and complement-c1q tumor necrosis factor-related protein (C1qtnf5) mRNAs, complete cds.
BC023068 - Mus musculus C1q and tumor necrosis factor related protein 5, mRNA (cDNA clone MGC:38635 IMAGE:5355789), complete cds.
DQ002398 - Mus musculus C1qTNF5 (C1qtnf5) mRNA, complete cds.
BC025174 - Mus musculus C1q and tumor necrosis factor related protein 5, mRNA (cDNA clone MGC:36714 IMAGE:3978387), complete cds.

-  Other Names for This Gene
  Alternate Gene Symbols: C1QT5_MOUSE, Ctrp5, NM_145613, Q8K479, uc009pbs.1, uc009pbs.2, uc009pbs.3
UCSC ID: uc009pbs.3
RefSeq Accession: NM_001190314
Protein: Q8K479 (aka C1QT5_MOUSE)
CCDS: CCDS52777.1

-  Gene Model Information
  Click here for a detailed description of the fields of the table above.

-  Methods, Credits, and Use Restrictions
  Click here for details on how this gene model was made and data restrictions if any.